Results 31 to 40 of about 32,631 (184)

BK Polyomavirus Evades Innate Immune Sensing by Disrupting the Mitochondrial Network and Promotes Mitophagy

iScience, 2020
Summary Immune escape contributes to viral persistence, yet little is known about human polyomaviruses. BK-polyomavirus (BKPyV) asymptomatically infects 90% of humans but causes premature allograft failure in kidney transplant patients.
Julia Manzetti, F. Weissbach, Fabrice E. Graf, Gunhild Unterstab, M. Wernli, H. Hopfer, C. Drachenberg, C. Rinaldo, H. Hirsch   +8 more
semanticscholar   +1 more source

Persistently high-level polyomavirus BK replication in the absence of renal function abnormalities in a kidney transplant recipient

Microbiologia Medica, 2016
Polyomavirus-associated nephropathy is an important cause of allograft dysfunction and graft loss after kidney transplantation. Even if histological evaluation is the gold standard for graft study and diagnosis of polyomavirus-associated nephropathy, K ...
Antonio Curtoni, Cristina Costa, Maria Messina, Francesca Sidoti, Andrea Piceghello, Gabriele Bianco, Luigi Biancone, Giuseppe Paolo Segoloni, Rossana Cavallo   +8 more
doaj   +1 more source

Acquisition of Human Polyomaviruses in the First 18 Months of Life

Emerging Infectious Diseases, 2015
We investigated the presence of 4 human polyomaviruses (PyVs) (WU, KI, Merkel cell, and Malawi) in respiratory specimens from a community-based birth cohort. These viruses typically were acquired when children were ≈1 year of age.
Rebecca Rockett, Seweryn Bialasiewicz, Lebogang Mhango, Jane Gaydon, Rebecca Holding, David Whiley, Stephen B. Lambert, Robert S. Ware, Michael D. Nissen, Keith Grimwood, Theo P. Sloots   +10 more
doaj   +1 more source

Single-Cell, High-Content Microscopy Analysis of BK Polyomavirus Infection

Microbiology Spectrum, 2023
By adulthood, the majority of the population is persistently infected with BK polyomavirus (BKPyV). Only a subset of the population, generally transplant recipients on immunosuppressive drugs, will experience disease from BKPyV, but those who do have few
Megan C. Procario, Jonathan Z. Sexton, Benjamin S. Halligan, Michael J. Imperiale   +3 more
doaj   +1 more source

Optimization of Adcitmer, a Monomethyl-Auristatin E bearing antibody-drug conjugate for the treatment of CD56-expressing cancers

Journal for ImmunoTherapy of Cancer
The cell adhesion protein CD56 has been identified as a potential therapeutic target in several solid tumors and hematological malignancies. Recently, we developed a CD56-directed antibody-drug conjugate (ADC), called Adcitmer and demonstrated its ...
David Schrama, Antoine Touze, Thibault Kervarrec, Mahtab Samimi, Valérie Gouilleux-Gruart, Aurelie Drouin, Laurine Durand, Clara Esnault, Pauline Gaboriaud, Valérie Leblond, Shawk Karim, Morgane Fouché, Christine Dhommée, Christine B Baltus, Fanny Boursin, Nicolas Aubrey, Roland Houben, Serge Guyétant, Audrey Desgranges, Marie Claude Viaud-Massuard   +19 more
doaj   +1 more source

Taking the Scenic Route: Polyomaviruses Utilize Multiple Pathways to Reach the Same Destination

Viruses, 2020
Members of the Polyomaviridae family differ in their host range, pathogenesis, and disease severity. To date, some of the most studied polyomaviruses include human JC, BK, and Merkel cell polyomavirus and non-human subspecies murine and simian virus 40 ...
Colleen L. Mayberry, Melissa S. Maginnis
doaj   +1 more source

The Second International Consensus Guidelines on the Management of BK Polyomavirus in Kidney Transplantation

Transplantation
BK polyomavirus (BKPyV) remains a significant challenge after kidney transplantation. International experts reviewed current evidence and updated recommendations according to Grading of Recommendations, Assessment, Development, and Evaluations (GRADE ...
C. Kotton, N. Kamar, David Wojciechowski, Michael Eder, Helmut Hopfer, Parmjeet S. Randhawa, Martina Sester, Patrizia Comoli, Helio Jr Tedesco Silva, Greg Knoll, Daniel C. Brennan, J. Trofe-Clark, Lars Pape, David Axelrod, B. Kiberd, Germaine Wong, Hans H. Hirsch   +16 more
semanticscholar   +1 more source

BK Polyomavirus: Clinical Aspects, Immune Regulation, and Emerging Therapies

Clinical Microbiology Reviews, 2017
SUMMARY BK polyomavirus (BKV) causes frequent infections during childhood and establishes persistent infections within renal tubular cells and the uroepithelium, with minimal clinical implications.
George R. Ambalathingal, R. Francis, M. Smyth, Corey Smith, R. Khanna   +4 more
semanticscholar   +1 more source

Sirolimus and Other Mechanistic Target of Rapamycin Inhibitors Directly Activate Latent Pathogenic Human Polyomavirus Replication

Journal of Infectious Diseases, 2020
Background Human polyomaviruses can reactivate in transplant patients, causing nephropathy, progressive multifocal leukoencephalopathy, Merkel cell carcinoma, pruritic, rash or trichodysplasia spinulosa.
Jennifer Alvarez Orellana, H. Kwun, S. Artusi, Yuan Chang, P. Moore   +4 more
semanticscholar   +1 more source

The Ancient Evolutionary History of Polyomaviruses.

PLoS Pathogens, 2016
Polyomaviruses are a family of DNA tumor viruses that are known to infect mammals and birds. To investigate the deeper evolutionary history of the family, we used a combination of viral metagenomics, bioinformatics, and structural modeling approaches to ...
Christopher B Buck, Koenraad Van Doorslaer, Alberto Peretti, Eileen M Geoghegan, Michael J Tisza, Ping An, Joshua P Katz, James M Pipas, Alison A McBride, Alvin C Camus, Alexa J McDermott, Jennifer A Dill, Eric Delwart, Terry F F Ng, Kata Farkas, Charlotte Austin, Simona Kraberger, William Davison, Diana V Pastrana, Arvind Varsani   +19 more
doaj   +1 more source