Results 51 to 60 of about 32,631 (184)

Human Polyomaviruses in Children Undergoing Transplantation, United States, 2008–2010

Emerging Infectious Diseases, 2012
Immunocompromised patients are at risk for disease caused by infection by some polyomaviruses. To define the prevalence of polyomaviruses in children undergoing transplantation, we collected samples from a longitudinal cohort and tested for the 9 known ...
Erica A. Siebrasse, Irma Bauer, Lori R. Holtz, Binh-minh Le, Sherry Lassa-Claxton, Charles Canter, Paul Hmiel, Shalini Shenoy, Stuart Sweet, Yumirle Turmelle, Ross Shepherd, David Wang   +11 more
doaj   +1 more source

Association Between the Time of Day of Post‐Transplant Cyclophosphamide Administration and Haemorrhagic Cystitis After Allogeneic Haematopoietic Stem Cell Transplantation

European Journal of Haematology, EarlyView.
ABSTRACT Objective To evaluate the impact of the time‐of‐day (daytime vs. nighttime) of the infusion of post‐transplantation cyclophosphamide (PTCy) on the occurrence of haemorrhagic cystitis (HC) in adult patients undergoing allogeneic haematopoietic stem cell transplantation (allo‐HSCT).
Maria‐Estela Moreno‐Martinez, Mireia Riba, Albert Esquirol, Irene García‐Cadenas, Clara Vila‐Gallego, Jose Manuel Portos, Ignasi Gich, Annalisa Paviglianiti, Sara Redondo, Javier Briones, Anna Feliu, Rodrigo Martino   +11 more
wiley   +1 more source

Merkel cell carcinoma: an updated guide for pathologists

Histopathology, EarlyView.
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma for which the differential diagnosis can include other small cell malignancies (especially metastatic small cell carcinoma) or cutaneous carcinoma. Morphologic and immunophenotypic aberrancies in MCC can increase diagnostic challenge.
Paul W. Harms
wiley   +1 more source

The lymphocyte function of allogeneic peripheral blood stem cell grafts is associated with relapse and cytomegalovirus reactivation

Transfusion, EarlyView.
Abstract Background Allogeneic hematopoietic stem cell transplantation (HSCT) is a treatment primarily for hematological malignancies. Infections, relapse, and graft versus host disease (GvHD) are some of the most common adverse events following HSCT. We aimed to evaluate whether the lymphocyte function of the stem cell graft was associated with these ...
Anna Söderström, Tengyu Wang, Johan Törlén, Hannes Lindahl, Davide Valentini, Stephan Mielke, Klara Asplund Högelin, Rebecca Axelsson Robertson, Michael Uhlin   +8 more
wiley   +1 more source

Human polyomavirus BKV infection of endothelial cells results in interferon pathway induction and persistence

PLoS Pathogens, 2019
Polyomavirus BKV is highly prevalent among humans. The virus establishes an asymptomatic persistent infection in the urinary system in healthy people, but uncontrolled productive infection of the virus in immunocompromised patients can lead to serious ...
P. An, M. Sáenz-Robles, Alexis M Duray, P. Cantalupo, J. Pipas   +4 more
semanticscholar   +1 more source

Polyomavirus T Antigen Induces APOBEC3B Expression Using an LXCXE-Dependent and TP53-Independent Mechanism

mBio, 2019
APOBEC3B is a single-stranded DNA cytosine deaminase with beneficial innate antiviral functions. However, misregulated APOBEC3B can also be detrimental by inflicting APOBEC signature C-to-T and C-to-G mutations in genomic DNA of multiple cancer types ...
Gabriel J. Starrett, Artur A. Serebrenik, Pieter A. Roelofs, Jennifer L. McCann, Brandy Verhalen, Matthew C. Jarvis, Teneale A. Stewart, Emily K. Law, Annabel Krupp, Mengxi Jiang, John W. M. Martens, Ellen Cahir-McFarland, Paul N. Span, Reuben S. Harris   +13 more
doaj   +1 more source

mSphere of Influence: It’s Not Me, It’s You—How Donor Factors Influence Kidney Transplant Outcomes

mSphere, 2020
Diana V. Pastrana works in the field of DNA tumor virus biology. In this mSphere of Influence article, she reflects on how the two papers “Donor origin of BKV replication after kidney transplantation” (C. Schmitt, L. Raggub, S. Linnenweber-Held, O. Adams,
Diana Valeria Pastrana
doaj   +1 more source

Merkel Cell Carcinoma With Divergent Differentiation—Or Something Else? A Triphasic Cutaneous Carcinoma With Lineage Plasticity

Journal of Cutaneous Pathology, Volume 53, Issue 11, Page 994-999, November 2026.
ABSTRACT Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine carcinoma that typically arises in sun‐exposed skin of older or immunosuppressed patients. Combined or collision tumors involving MCC and other cutaneous malignancies are uncommon, and tumors exhibiting more than two distinct malignant phenotypes are exceptionally rare.
Zeinab Khalil, Hozaifa Elameen, Ahmed K. Alomari   +2 more
wiley   +1 more source

Chk1 and the Host Cell DNA Damage Response as a Potential Antiviral Target in BK Polyomavirus Infection

Viruses, 2021
The human BK polyomavirus (BKPyV) is latent in the kidneys of most adults, but can be reactivated in immunosuppressed states, such as following renal transplantation.
Lydia E. Hainley, Martina S. Hughson, Amithi Narendran, Ralph Smith, Justin Arthur, Alida Hayner-Buchan, David J. Conti, John M. Lehman, Thomas D. Friedrich   +8 more
doaj   +1 more source

Lanreotide, a Somatostatin Analogue, in Advanced Merkel Cell Carcinoma: A Prospective Single‐Arm Phase II Study

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Merkel Cell Carcinoma (MCC) is a rare, aggressive neuroendocrine and epithelial skin cancer. Somatostatin analogues, such as lanreotide, have shown efficacy in managing other neuroendocrine tumors. Retrospective studies suggest that lanreotide may induce partial response or disease stabilization in patients with advanced MCC.
Julie Charles, Aude Belbezier, Stéphane Mouret, Brigitte Dreno, Stéphane Dalle, Céleste Lebbe, Ewa Hainaut‐Wierzbicka, Andreea Stefan, Julie de Quatrebarbes, Olivier Dereure, Ouidad Zehou, Sandrine Mansard, Alain Dupuy, Caroline Dutriaux, Florent Grange, Caroline Gaudy‐Marqueste, Henri Montaudié, Jean‐Philippe Arnault, Yannick Le Corre, Thibault Kervarrec, Jean‐Louis Quesada, Mahtab Samimi, Marie‐Thérèse Leccia, The Group of Cutaneous Oncology of the French Society of Dermatology   +23 more
wiley   +1 more source