Results 1 to 10 of about 1,873 (184)

Unveiling Donor-Derived BKPyV DNAemia Through Analysis of Contralateral Kidney Transplant Recipients [PDF]

Biomedicines
Background: BK polyomavirus (BKPyV) infection is of notable concern in kidney transplant recipients, as it can cause BKPyV-associated nephropathy (BKPyVAN).
Wouter T. Moest, A. Lianne Messchendorp, Helma Dolmans, Cynthia Konijn-Janssen, Stan van den Eijnden, Milou van Bruchem, Ineke Tieken, Maarten H. L. Christiaans, Arjan D. van Zuilen, Marcia M. L. Kho, Irma Stijnman, Frederike J. Bemelman, Jan-Stephan S. Sanders, Mariet C. W. Feltkamp, Aiko P. J. de Vries, Joris I. Rotmans   +15 more
doaj   +7 more sources

Pretransplantation seroreactivity in kidney donors and recipients as a predictive factor for posttransplant BKPyV-DNAemia [PDF]

Frontiers in Immunology, 2022
BK polyomavirus (BKPyV) often reactivates after kidney transplantation, causing BKPyV-associated nephropathy (BKPyVAN) in 1%–10% of cases with a potential detrimental effect on allograft survival.
Martina Saláková, Viera Ludvíková, Eva Hamšíková, Marie Kolářová, Vojtěch Šroller, Ondřej Viklický, Mariana Wohlfahrtová   +6 more
doaj   +5 more sources

BKPyV DNAemia in Kidney Transplant Recipients Undergoing Regular Screening: A Single-Centre Cohort Study [PDF]

Microorganisms, 2023
Infection with BK polyomavirus (BKPyV) is a common opportunistic infection after kidney transplantation (KT) and may affect graft function. We aimed to determine the incidence, risk factors, and clinical outcomes of BKPyV DNAemia in a prospective cohort ...
Daniel B. Rasmussen, Dina L. Møller, Sebastian R. Hamm, Álvaro H. Borges, Alex C. Y. Nielsen, Nikolai S. Kirkby, Søren S. Sørensen, Susanne D. Nielsen   +7 more
doaj   +5 more sources

The Burden of BK Polyomavirus in Pediatric Renal Transplantation: A Belgian Experience [PDF]

Biomedicines
Background/Objectives: To evaluate the outcome of developing BKPyV-DNAemia and presumptive BKPyV-nephropathy (BKPyV-DNAemia ≥ 104 copies/mL for more than 2 weeks) within the first 2 years post-transplant in a Belgian population of renal transplanted ...
Pauline Guillaume-Gentil, Benedetta Chiodini, Brigitte Adams, Jean Herman, Maria Van Dyck, Khalid Ismaili   +5 more
doaj   +2 more sources

Divergent Cellular and Humoral Immunity to BK Polyomavirus in Healthy Adults and Renal Transplant Recipients Based on Blood and Urine Samples: Implications for Immune-Guided Monitoring [PDF]

Biomedicines
Background/Objectives: BK polyomavirus (BKPyV) establishes lifelong, asymptomatic persistence but frequently reactivates in renal transplant recipients, contributing to significant post-transplant morbidity.
Deema Ibrahim Fallatah, Steve Christmas
doaj   +2 more sources

Explorative Insights into Local Immune Response to BK Virus—A Cross-Sectional Study in Urine Samples Between Transplant Recipients and Non-Immunocompromised Hosts [PDF]

Medicina
Background and Objectives: BK virus (BKPyV) is a common latent pathogen in humans, but it becomes particularly insidious in kidney transplant recipients, where reactivation may contribute to allograft loss. The immune mechanisms controlling BKPyV latency
Agata Michnowska, Bartosz Wojciuk, Paulina Reus, Agata Filipowska, Magdalena Mnichowska-Polanowska, Bartłomiej Grygorcewicz, Kazimierz Ciechanowski, Karolina Kędzierska-Kapuza   +7 more
doaj   +2 more sources

The inhibitory receptor NKG2A is expressed on T-cells during BKPyVANephropathy [PDF]

Frontiers in Immunology
IntroductionBKPyV-associated nephropathy (BKPyVAN) is a major complication in kidney transplantation. An exhaustion of BKPyV-specific T-cells but not T-cells against other viruses is observed, suggesting a mechanism specifically mediated by BKPyV ...
Karen Bargiel, Karen Bargiel, Christophe Desterke, Christophe Desterke, Manon Dekeyser, Manon Dekeyser, Manon Dekeyser, Marion Rabant, Marion Rabant, Lea Dutour, Amelie Grosjean, Arthur Tenenhaus, Amelia Vernochet, Amelia Vernochet, Florence Herr, Florence Herr, Antoine Durrbach, Antoine Durrbach, Antoine Durrbach   +18 more
doaj   +2 more sources

ISG20 Restricts BK Polyomavirus Infection and Engages in Reciprocal Regulation with Viral Large T Antigen [PDF]

Microorganisms
BK polyomavirus (BKPyV) causes severe urinary tract diseases, including BKPyV-associated nephropathy (BKPyVN) and ureteric stenosis, in immunocompromised individuals such as renal transplant recipients.
Yumin Hou, Chunlan Hu, Yejing Shi, Xiaohui Zhou, Tongyu Zhu, Nannan Wu   +5 more
doaj   +2 more sources

Clinical Associations and Coexistence of Polyomavirus DNAemia with EBV and CMV in Pediatric Hematology/Oncology Patients, Including HCT Recipients—A Pilot Study [PDF]

Pathogens
Polyomaviruses (BKPyV and JCPyV) and herpesviruses (EBV, CMV) usually infect people during childhood, and may be associated, in some clinical states, with immunocompromised individuals.
Tomasz Bogiel, Mateusz Rzepka, Dagmara Depka-Radzikowska, Patrycja Zalas-Więcek, Krzysztof Czyżewski, Monika Richert-Przygońska, Jan Styczyński, Robert Dębski, Elżbieta Grześk, Grzegorz Grześk, Piotr Kanarek, Agnieszka Krawczyk   +11 more
doaj   +2 more sources

Prolonged Prophylactic Ureteral Stent Placement and BK Polyomavirus Infection After Renal Transplantation—A Retrospective Case-control Study [PDF]

European Urology Open Science
Background and objective: BK polyomavirus (BKPyV) poses a significant challenge in kidney transplant (KTX) recipients, potentially leading to BKPyV-associated nephropathy.
Haris Omić, Simon Hoffmann, Michael Eder, Robert Strassl, Daniela Gerges, Shahrokh F. Shariat, Željko Kikić   +6 more
doaj   +2 more sources