Results 1 to 10 of about 2,183 (154)

Pretransplantation seroreactivity in kidney donors and recipients as a predictive factor for posttransplant BKPyV-DNAemia

Frontiers in Immunology, 2022
BK polyomavirus (BKPyV) often reactivates after kidney transplantation, causing BKPyV-associated nephropathy (BKPyVAN) in 1%–10% of cases with a potential detrimental effect on allograft survival.
Martina Salakova, Viera Ludvikova, Eva Hamsikova   +2 more
exaly   +3 more sources

Unveiling Donor-Derived BKPyV DNAemia Through Analysis of Contralateral Kidney Transplant Recipients [PDF]

Biomedicines
Background: BK polyomavirus (BKPyV) infection is of notable concern in kidney transplant recipients, as it can cause BKPyV-associated nephropathy (BKPyVAN).
Wouter T. Moest, A. Lianne Messchendorp, Helma Dolmans, Cynthia Konijn-Janssen, Stan van den Eijnden, Milou van Bruchem, Ineke Tieken, Maarten H. L. Christiaans, Arjan D. van Zuilen, Marcia M. L. Kho, Irma Stijnman, Frederike J. Bemelman, Jan-Stephan S. Sanders, Mariet C. W. Feltkamp, Aiko P. J. de Vries, Joris I. Rotmans   +15 more
doaj   +2 more sources

The Burden of BK Polyomavirus in Pediatric Renal Transplantation: A Belgian Experience [PDF]

Biomedicines
Background/Objectives: To evaluate the outcome of developing BKPyV-DNAemia and presumptive BKPyV-nephropathy (BKPyV-DNAemia ≥ 104 copies/mL for more than 2 weeks) within the first 2 years post-transplant in a Belgian population of renal transplanted ...
Pauline Guillaume-Gentil, Benedetta Chiodini, Brigitte Adams, Jean Herman, Maria Van Dyck, Khalid Ismaili   +5 more
doaj   +2 more sources

Modelling BK Polyomavirus dissemination and cytopathology using polarized human renal tubule epithelial cells. [PDF]

PLoS Pathogens, 2023
Most humans have a lifelong imperceptible BK Polyomavirus (BKPyV) infection in epithelial cells lining the reno-urinary tract. In kidney transplant recipients, unrestricted high-level replication of donor-derived BKPyV in the allograft underlies ...
Elias Myrvoll Lorentzen, Stian Henriksen, Christine Hanssen Rinaldo   +2 more
doaj   +3 more sources

The inhibitory receptor NKG2A is expressed on T-cells during BKPyVANephropathy [PDF]

Frontiers in Immunology
IntroductionBKPyV-associated nephropathy (BKPyVAN) is a major complication in kidney transplantation. An exhaustion of BKPyV-specific T-cells but not T-cells against other viruses is observed, suggesting a mechanism specifically mediated by BKPyV ...
Karen Bargiel, Karen Bargiel, Christophe Desterke, Christophe Desterke, Manon Dekeyser, Manon Dekeyser, Manon Dekeyser, Marion Rabant, Marion Rabant, Lea Dutour, Amelie Grosjean, Arthur Tenenhaus, Amelia Vernochet, Amelia Vernochet, Florence Herr, Florence Herr, Antoine Durrbach, Antoine Durrbach, Antoine Durrbach   +18 more
doaj   +2 more sources

Transplant failure in relation to BK viremia status among kidney transplant recipients in Jordan [PDF]

Iranian Journal of Microbiology
Background and Objectives: BK polyomavirus (BKPyV) poses a significant threat to kidney transplant (KT) recipients due to immunosuppression, leading to BK-associated nephropathy (BKVN) and reduced transplant survival.
Rabaa Y. Athamneh, Reema Bani Saeed, Omaymah Abulannaz, Rawan Abudalo, Muna Oqal   +4 more
doaj   +2 more sources

Explorative Insights into Local Immune Response to BK Virus—A Cross-Sectional Study in Urine Samples Between Transplant Recipients and Non-Immunocompromised Hosts [PDF]

Medicina
Background and Objectives: BK virus (BKPyV) is a common latent pathogen in humans, but it becomes particularly insidious in kidney transplant recipients, where reactivation may contribute to allograft loss. The immune mechanisms controlling BKPyV latency
Agata Michnowska, Bartosz Wojciuk, Paulina Reus, Agata Filipowska, Magdalena Mnichowska-Polanowska, Bartłomiej Grygorcewicz, Kazimierz Ciechanowski, Karolina Kędzierska-Kapuza   +7 more
doaj   +2 more sources

Prolonged Prophylactic Ureteral Stent Placement and BK Polyomavirus Infection After Renal Transplantation—A Retrospective Case-control Study [PDF]

European Urology Open Science
Background and objective: BK polyomavirus (BKPyV) poses a significant challenge in kidney transplant (KTX) recipients, potentially leading to BKPyV-associated nephropathy.
Haris Omić, Simon Hoffmann, Michael Eder, Robert Strassl, Daniela Gerges, Shahrokh F. Shariat, Željko Kikić   +6 more
doaj   +2 more sources

Biology of the BKPyV: An Update

Viruses, 2017
The BK virus (BKPyV) is a member of the Polyomaviridae family first isolated in 1971. BKPyV causes frequent infections during childhood and establishes persistent infections with minimal clinical implications within renal tubular cells and the urothelium.
François Helle, Etienne Brochot, Lynda Handala   +2 more
exaly   +3 more sources

ISG20 Restricts BK Polyomavirus Infection and Engages in Reciprocal Regulation with Viral Large T Antigen [PDF]

Microorganisms
BK polyomavirus (BKPyV) causes severe urinary tract diseases, including BKPyV-associated nephropathy (BKPyVN) and ureteric stenosis, in immunocompromised individuals such as renal transplant recipients.
Yumin Hou, Chunlan Hu, Yejing Shi, Xiaohui Zhou, Tongyu Zhu, Nannan Wu   +5 more
doaj   +2 more sources