Results 31 to 40 of about 2,252 (197)

Pretransplant BK Virus-Specific T-Cell-Mediated Immunity and Serotype Specific Antibodies May Have Utility in Identifying Patients at Risk of BK Virus-Associated Haemorrhagic Cystitis after Allogeneic HSCT

Vaccines, 2021
BK polyomavirus (BKPyV) persists lifelong in renal and urothelial cells with asymptomatic urinary shedding in healthy individuals. In some immunocompromised persons after transplantation of hematopoietic stem cells (HSCT), the BKPyV high-rate replication
Markéta Šťastná-Marková, Eva Hamšíková, Petr Hainz, Petr Hubáček, Marie Kroutilová, Jitka Kryštofová, Viera Ludvíková, Jan Musil, Pavla Pecherková, Martina Saláková, Vojtěch Šroller, Jan Vydra, Šárka Němečková   +12 more
doaj   +1 more source

The differential presence of human polyomaviruses, JCPyV and BKPyV, in prostate cancer and benign prostate hypertrophy tissues [PDF]

BMC Cancer, 2021
Abstract Background Studies have shown that human polyomavirus infection may be associated with various human cancers. We investigated the potential relationship between the prevalence of JCPyVor BKPyV and prostate cancer (PC) in patients from Taiwan.
Chenghuang Shen, Chunliang Tung, Chunnun Chao, Yeongchin Jou, Shupei Huang, Menghsiao Meng, Deching Chang, Peilain Chen   +7 more
openaire   +3 more sources

Intracellular Low Iron Exerts Anti-BK Polyomavirus Effect by Inhibiting the Protein Synthesis of Exogenous Genes

Microbiology Spectrum, 2021
BK polyomavirus (BKPyV) is a small double-stranded DNA virus and ubiquitous human pathogen that particularly affects immunocompromised individuals. Antiviral therapy for BKPyV is urgently needed.
Jiajia Sun, Yejing Shi, Huichun Shi, Yumin Hou, Chunlan Hu, Yigang Zeng, Guoyi Wu, Tongyu Zhu   +7 more
doaj   +1 more source

Impact of pre-graft serology on risk of BKPyV infection post-renal transplantation

Nephrology Dialysis Transplantation, 2021
ABSTRACT Objectives BK polyomavirus-associated nephropathy is a troublesome disease caused by BK polyomavirus (BKPyV) infection in immunocompromised renal graft recipients. There are no effective treatments available, making immunosuppression reduction the only management option.
Dakroub, Fatima, Touzé, Antoine, Abdel Sater, Fadi, Fiore, Toni, Morel, Virginie, Tinez, Claire, Helle, François, François, Catherine, Choukroun, Gabriel, Presne, Claire, Guillaume, Nicolas, Duverlie, Gilles, Castelain, Sandrine, Akl, Haidar, Brochot, Etienne   +14 more
openaire   +4 more sources

Indoleamine 2,3-Dioxygenase Is Involved in Interferon Gamma’s Anti-BKPyV Activity in Renal Cells [PDF]

Viruses, 2020
Reactivation of BK polyomavirus (BKPyV) infection is frequently increasing in transplant recipients treated with potent immunosuppressants and highlights the importance of immune system components in controlling viral reactivation. However, the immune response to BKPyV in general and the role of antiviral cytokines in infection control in particular ...
Tony Fiore, Elodie Martin, Véronique Descamps, Etienne Brochot, Virginie Morel, Lynda Handala, Fatima Dakroub, Sandrine Castelain, Gilles Duverlie, François Helle, Catherine François   +10 more
openaire   +3 more sources

Mother-to-child transmission of oncogenic polyomaviruses BKPyV, JCPyV and SV40

Journal of Infection, 2020
Polyomavirus (PyV) infections have been associated with different diseases. BK (BKPyV), JC (JCPyV) and simian virus 40 (SV40) are the three main PyVs whose primary infection occurs early in life. Their vertical transmission was investigated in this study.PyV sequences were analyzed by the digital droplet PCR in blood, serum, placenta, amniotic fluid ...
Elisa Mazzoni, Elena Pellegrinelli, Chiara Mazziotta, Carmen Lanzillotti, John Charles Rotondo, Ilaria Bononi, Maria Rosa Iaquinta, Marco Manfrini, Fortunato Vesce, Mauro Tognon, Fernanda Martini   +10 more
openaire   +2 more sources

An Unexpected Surge in Plasma BKPyV Viral Load Heralds the Development of BKPyV-Associated Metastatic Bladder Cancer in a Lung Transplant Recipient With BKPyV Nephropathy

American Journal of Transplantation, 2017
We report a lung transplant recipient who developed BK polyoma virus (BKPyV) DNAemia and BKPyV nephropathy. With careful management of his immunosuppression he achieved significant reduction in BKPyV DNAemia and stabilization of his kidney function. He later developed a high-grade bladder cancer and shortly thereafter he experienced a major upsurge in ...
S, Kuppachi, D, Holanda, M, Eberlein, B, Alexiev, A J, Tyler, M C, Wissel, S B, Kleiboeker, C P, Thomas   +7 more
openaire   +2 more sources

Identification of Rab18 as an Essential Host Factor for BK Polyomavirus Infection Using a Whole-Genome RNA Interference Screen

mSphere, 2017
BK polyomavirus (BKPyV) is a human pathogen first isolated in 1971. BKPyV infection is ubiquitous in the human population, with over 80% of adults worldwide being seropositive for BKPyV.
Linbo Zhao, Michael J. Imperiale
doaj   +1 more source

Human polyomaviruses in children undergoing transplantation, United States, 2008-2010 [PDF]

, 2012
Immunocompromised patients are at risk for disease caused by infection by some polyomaviruses. To define the prevalence of polyomaviruses in children undergoing transplantation, we collected samples from a longitudinal cohort and tested for the 9 known ...
Bauer, Irma, Canter, Charles, Hmiel, Paul, Holtz, Lori R, Lassa-Claxton, Sherry, Le, Binh-minh, Shenoy, Shalini, Shepherd, Ross, Siebrasse, Erica A, Sweet, Stuart, Turmelle, Yumirle, Wang, David   +11 more
core   +2 more sources

BK Polyomavirus MicroRNA Levels in Exosomes Are Modulated by Non-Coding Control Region Activity and Down-Regulate Viral Replication When Delivered to Non-Infected Cells Prior to Infection

Viruses, 2018
In immunosuppressed patients, BKPyV-variants emerge carrying rearranged non-coding control-regions (rr-NCCRs) that increase early viral gene region (EVGR) expression and replication capacity.
Francesco Martelli, Zongsong Wu, Serena Delbue, Fabian H. Weissbach, Maria Chiara Giulioli, Pasquale Ferrante, Hans H. Hirsch, Simone Giannecchini   +7 more
doaj   +1 more source