Results 41 to 50 of about 1,873 (184)

Impaired CD4+ Cytotoxic T Lymphocyte Activity in Polyomavirus BK Infected Kidney Transplant Recipients

Iranian Journal of Allergy, Asthma and Immunology, 2023
The reactivation of polyomavirus BK (BKPyV) contributes to increased morbidity and mortality rates of transplant patients, especially kidney transplant recipients (KTRs).
Nasrin Noshadi, Ramin Yaghoubi, Afsoon Afshari, Mohsen Forouzanfar, Saeede soleimanian   +4 more
doaj   +1 more source

IgG Seroreactivites to Viral Capsid Protein VP1 of JC and BK Polyomaviruses in Children at Early Ages with Special Reference to Parental Cofactors

Children, 2023
BK (BKPyV) and JC (JCPyV) polyomaviruses are widespread in humans. Transmission at an early age and the role of parents in spreading these viruses through the family are incompletely understood.
Hanna K. Laine, Tim Waterboer, Kari Syrjänen, Seija Grenman, Karolina Louvanto, Stina Syrjänen   +5 more
doaj   +1 more source

HLA-B Leader Dimorphism Predicts BK Polyomavirus Replication After Kidney Transplant. [PDF]

HLA
ABSTRACT BK polyomavirus (BKPyV) and Cytomegalovirus (CMV) often replicate after kidney transplantation, with management limited to reducing immunosuppression and risking rejection. Among genetic factors that may modulate the antiviral response, HLA evolutionary divergence (HED, allowing a greater diversity of antigen presentation) and the HLA‐B leader
Aubry A, Demey B, Helle F, Fourdinier O, Lion J, Desoutter J, Brochot E, Guillaume N.   +7 more
europepmc   +2 more sources

BK polyomavirus infection promotes growth and aggressiveness in bladder cancer

Virology Journal, 2020
Background Recent studies have confirmed the integration of the BK polyomavirus (BKPyV) gene into the cellular genome of urothelial carcinomas in transplant recipients, further confirming the correlation between BKPyV and urothelial carcinomas after ...
Yigang Zeng, Jiajia Sun, Juan Bao, Tongyu Zhu   +3 more
doaj   +1 more source

Rejection after BKPyV DNAemia-Are We Treating Too Cautiously? [PDF]

Transpl Int
Moest WT, de Vries APJ, van Rijn AL, van der Helm D, Kers J, Feltkamp MCW, Rotmans JI.   +6 more
europepmc   +3 more sources

Anion homeostasis is important for non-lytic release of BK polyomavirus from infected cells [PDF]

Open Biology, 2015
BK polyomavirus (BKPyV) is a member of a family of potentially oncogenic viruses, whose reactivation can cause severe pathological conditions in transplant patients, leading to graft rejection. As with many non-enveloped viruses, it is assumed that virus
Gareth L. Evans, Laura G. Caller, Victoria Foster, Colin M. Crump   +3 more
doaj   +1 more source

Indoleamine 2,3-Dioxygenase Is Involved in Interferon Gamma’s Anti-BKPyV Activity in Renal Cells [PDF]

Viruses, 2020
Reactivation of BK polyomavirus (BKPyV) infection is frequently increasing in transplant recipients treated with potent immunosuppressants and highlights the importance of immune system components in controlling viral reactivation. However, the immune response to BKPyV in general and the role of antiviral cytokines in infection control in particular ...
Tony Fiore, Elodie Martin, Véronique Descamps, Etienne Brochot, Virginie Morel, Lynda Handala, Fatima Dakroub, Sandrine Castelain, Gilles Duverlie, François Helle, Catherine François   +10 more
openaire   +3 more sources

BKPyV replication leads to shedding of infectious decoy cells.

, 2023
Widefield microscopy of detached cells harvested from supernatants of mock infected and BKPyV infected (MOI 1) polarized RPTECs at 5 dpi. Harvested cells were imaged with phase-contrast and fluorescence microscopy.
Christine Hanssen Rinaldo (16892416), Elias Myrvoll Lorentzen (16892410), Stian Henriksen (16892413)   +2 more
core   +1 more source

In Vitro Generation of BK polyomavirus-specific T cells for adoptive cell therapy in refractory cystitis hemorrhagic patients after hematopoietic stem cell transplantation

BMC Immunology, 2022
Introduction BKPyV associated hemorrhagic cystitis (BKPyV-HC) is a major and prevalent outcome of hematopoietic stem cell transplantation (HSCT) with no standard treatment option.
Maryam Mohammadi Najafabadi, Masoud Soleimani, Mohammad Ahmadvand, Mina Soufi Zomorrod, Seied Asadollah Mousavi   +4 more
doaj   +1 more source

Human Polyomavirus BK Genome Analysis in BKPyV Induced Rodent Cell Lines. [PDF]

Microbiologyopen
In this study, we analyzed the BK polyomavirus (BKPyV) genome derived from three rodent cell lines established from BKPyV induced tumors. BKPyV derived one cell line had a large deletion. The noncoding control region (NCCR) of BKPyV derived from these cell lines had the same structure as viruses induced tumors.
Shioda S, Kasai F, Ozawa M, Ohtani A, Iemura M, Watanabe K, Kohara A.   +6 more
europepmc   +2 more sources