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Biology of the BKPyV: An Update [PDF]

Viruses, 2017
The BK virus (BKPyV) is a member of the Polyomaviridae family first isolated in 1971. BKPyV causes frequent infections during childhood and establishes persistent infections with minimal clinical implications within renal tubular cells and the urothelium.
Francois Helle, Etienne Brochot, Lynda Handala, Elodie Martin, Sandrine Castelain, Catherine Francois, Gilles Duverlie   +6 more
doaj   +4 more sources

Control of BKPyV-DNAemia by a Tailored Viro-Immunologic Approach Does Not Lead to BKPyV-Nephropathy Progression and Development of Donor-Specific Antibodies in Pediatric Kidney Transplantation

Microorganisms
Polyomavirus BK (BKPyV)-associated nephropathy (BKPyV-nephropathy) remains a significant cause of premature kidney allograft failure. In the absence of effective antiviral treatments, current therapeutic approaches rely on immunosuppression (IS ...
Michela Cioni, Stella Muscianisi, Marica De Cicco, Sabrina Basso, Hans H. Hirsch, Iris Fontana, Laura Catenacci, Jessica Bagnarino, Mariangela Siciliano, Oriana Montana Lampo, Gloria Acquafredda, Lou Tina Diana Boti, Jessica Rotella, Eleonora Bozza, Jennifer Zumelli, Kristiana Mebelli, Fausto Baldanti, Massimo Cardillo, Marco Zecca, Arcangelo Nocera, Mario Luppi, Enrico Verrina, Fabrizio Ginevri, Patrizia Comoli   +23 more
doaj   +4 more sources

Clinically Relevant Reactivation of Polyomavirus BK (BKPyV) in HLA-A02-Positive Renal Transplant Recipients Is Associated with Impaired Effector-Memory Differentiation of BKPyV-Specific CD8+ T Cells.

PLoS Pathogens, 2016
Polyomavirus BK (BKPyV) frequently reactivates in immunosuppressed renal transplant recipients (RTRs) and may lead to graft loss due to BKPyV-induced interstitial nephritis (BKVN). Little is known on the differentiation of CD8+ T cells targeting BKPyV in
Michiel C van Aalderen, Ester B M Remmerswaal, Kirstin M Heutinck, Anja Ten Brinke, Mariet C W Feltkamp, Neelke C van der Weerd, Karlijn A M I van der Pant, Frederike J Bemelman, René A W van Lier, Ineke J M Ten Berge   +9 more
doaj   +6 more sources

Specific and quantitative detection of Human polyomaviruses BKPyV and JCPyV in the healthy Pakistani population [PDF]

Virology Journal, 2017
Background The BK Polyomavirus (BKPyV) and JC polyomavirus (JCPyV) infections are widespread in human population and have been associated with severe kidney and brain disorders, respectively.
Iqra Hussain, Fareeda Tasneem, Muhammed Umer, Ayesha Pervaiz, Muslim Raza, Muhammad Imran Arshad, Naveed Shahzad   +6 more
doaj   +5 more sources

The risk factors associated with post-transplantation BKPyV nephropathy and BKPyV DNAemia: a prospective study in kidney transplant recipients

BMC Infectious Diseases
Abstract Background BK polyomavirus (BKPyV) infection after kidney transplantation can lead to serious complications such as BKPyV-associated nephropathy (BKPyVAN) and graft loss. The aim of this study was to investigate the incidence of BKPyVAN after implementing a BKPyV screening program, to map the distribution of ...
Lorant, Camilla, Zigmantaviciute, Justina, Ali, Naima, Bonnevier, Ursa, Tejde, Mattias, von Zur-Mühlen, Bengt, Eriksson, Britt-Marie, Bergqvist, Anders, Westman, Gabriel   +8 more
openaire   +5 more sources

Impact of pre-graft serology on risk of BKPyV infection post-renal transplantation

Nephrology Dialysis Transplantation, 2021
ABSTRACT Objectives BK polyomavirus-associated nephropathy is a troublesome disease caused by BK polyomavirus (BKPyV) infection in immunocompromised renal graft recipients. There are no effective treatments available, making immunosuppression reduction the only management option.
Dakroub, Fatima, Touzé, Antoine, Abdel Sater, Fadi, Fiore, Toni, Morel, Virginie, Tinez, Claire, Helle, François, François, Catherine, Choukroun, Gabriel, Presne, Claire, Guillaume, Nicolas, Duverlie, Gilles, Castelain, Sandrine, Akl, Haidar, Brochot, Etienne   +14 more
openaire   +5 more sources

Mother-to-child transmission of oncogenic polyomaviruses BKPyV, JCPyV and SV40

Journal of Infection, 2020
Polyomavirus (PyV) infections have been associated with different diseases. BK (BKPyV), JC (JCPyV) and simian virus 40 (SV40) are the three main PyVs whose primary infection occurs early in life. Their vertical transmission was investigated in this study.PyV sequences were analyzed by the digital droplet PCR in blood, serum, placenta, amniotic fluid ...
Elisa Mazzoni, Elena Pellegrinelli, Chiara Mazziotta, Carmen Lanzillotti, John Charles Rotondo, Ilaria Bononi, Maria Rosa Iaquinta, Marco Manfrini, Fortunato Vesce, Mauro Tognon, Fernanda Martini   +10 more
openaire   +3 more sources

Can BKPyV Infection Affect Neoplasm Transformation Among Kidney Transplant Recipients? A Case Series Study Report [PDF]

Journal of Clinical Medicine
Background: There is a great deal of knowledge regarding the development of polyomavirus-associated nephropathy and polyomavirus-associated hemorrhagic cystitis in transplant recipients with active BKPyV infection. However, recent studies have revealed a
Magdalena Krajewska, Katarzyna Kościelska-Kasprzak, Paweł Poznański   +2 more
exaly   +3 more sources

Vigilância da replicação do poliomavírus humano BK (BKPyV) e evolução para Nefropatia Associada ao BKPyV (NABKPyV) em pacientes submetidos a transplante renal [PDF]

, 2018
INTRODUÇÃO: O BKPyV está associado à inflamação e perda da função do enxerto em pacientes transplantados renais. Nos pacientes transplantados renais, aproximadamente 40% dos receptores desenvolvem viruria pelo BKPyV em até 3 meses e 20% desenvolvem ...
Bicalho, Camila da Silva
openaire   +2 more sources

Neurological Disease-Affected Patients, including Multiple Sclerosis, Are Poor Responders to BKPyV, a Human Polyomavirus

Journal of Immunology Research, 2022
Multiple sclerosis (MS) is a neurological disease characterized by immune dysregulations. Different viruses may act as MS triggering agents. MS patients respond differently to distinct viruses. The aim of our study is to verify the association between the polyomavirus BKPyV and MS, together with other neurological diseases, through the investigation of
Bononi, Ilaria, Mazzoni, Elisa, Pietrobon, Silvia, Iaquinta, Maria Rosa, Caselli, Andrea, Torreggiani, Elena, Pugliatti, Maura, Casetta, Ilaria, Castellazzi, Massimiliano, Granieri, Enrico, Martini, Fernanda, Tognon, Mauro   +11 more
openaire   +5 more sources