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BK polyomavirus: emerging pathogen [PDF]

open access: yesMicrobes and Infection, 2012
BK polyomavirus (BKPyV) is a small double-stranded DNA virus that is an emerging pathogen in immunocompromised individuals. BKPyV is widespread in the general population, but primarily causes disease when immune suppression leads to reactivation of latent virus.
Michael Imperiale
exaly   +3 more sources

BK Polyomavirus Consensus

Clinical Infectious Diseases, 2022
To the editor—BK polyomavirus (BKPyV) continues to challenge kidney transplantation (KT) outcomes with premature renal allograft failure, and evidence-based treatment approaches based on randomized clinical trials are sorely lacking. Imlay and coauthors [1] address this unmet need and note that “definitions of proven disease are variable.” The ...
Hirsch, Hans   +2 more
openaire   +3 more sources

Antivirals for the treatment of polyomavirus BK replication

Expert Review of Anti-Infective Therapy, 2007
Antiviral drugs with specific activity against polyomavirus replication have not been developed in the past. This deficiency has become fully apparent with the emergence of polyomavirus-associated nephropathy in kidney-transplant recipients, with a prevalence rate of up to 10%. In most cases, high BK virus replication in tubular epithelial cells causes
Christine Hanssen Rinaldo, Hans H Hirsch
exaly   +3 more sources

Polyomavirus BK

The Lancet Infectious Diseases, 2003
Polyomavirus hominis 1, better known as BK virus (BKV), infects up to 90% of the general population. However, significant clinical manifestations are rare and limited to individuals with impaired immune functions. BKV has been associated with diverse entities such as haemorrhagic cystitis, ureteric stenosis, vasculopathy, pneumonitis, encephalitis ...
Hirsch HH, Steiger J
openaire   +3 more sources

Polyomavirus BK infection

Transplantation Proceedings, 2003
Because it is an important factor affecting renal transplant function, BK infections are significant problem in posttransplant. BK nephropathy develops in 5% of renal allograft recipients, in most cases within the first year after the procedure. The gold standard for BK nephropathy diagnosis is still immunohistochemical staining for large T antigen in ...
B, Matłosz   +11 more
openaire   +2 more sources

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