The emerging landscape of eukaryotic polyphosphatases
FEBS Letters, 2023 Polyphosphate (polyP) is a conserved polymer of inorganic phosphate residues that can reach thousands of moieties in length. PolyP has been implicated in cellular functions ranging from energy and phosphate homeostasis to cell signalling in eukaryotes from yeast to humans.
Liam McCarthy, Michael Downey
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Polyphosphate-mediated inhibition of tartrate-resistant acid phosphatase and suppression of bone resorption of osteoclasts. [PDF]
PLoS ONE, 2013 Inorganic polyphosphate (poly(P)) has recently been found to play an important role in bone formation. In this study, we found that tartrate-resistant acid phosphatase (TRAP), which is abundantly expressed in osteoclasts, has polyphosphatase activity ...
Kana Harada +7 more
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Stress Resistance of Saccharomyces cerevisiae Strains Overexpressing Yeast Polyphosphatases [PDF]
Stresses, 2022 Inorganic polyphosphate (polyP) is an important factor in the stress resistance of microorganisms. The polyphosphate-overexpressing strains of yeast S.
Nadeshda Andreeva +4 more
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Derepression of polyphosphatase in Escherichia coli by starvation for inorganic phosphate [PDF]
FEBS Letters, 1975 Several micro-organisms are known to accumulate polyphosphate (polyP) when subjected to unbalanced growth conditions such as low pH, sulphur starvation or following a period of phosphate-starvation. The accumulated polyP, which can be degraded, is thought to regulate the level of inorganic phosphorous (Pi) of the cells or, alternatively, to serve as a ...
E. Yagil, Yagil, E.
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NOA36 protein contains a highly conserved nucleolar localization signal capable of directing functional proteins to the nucleolus, in mammalian cells. [PDF]
PLoS ONE, 2013 NOA36/ZNF330 is an evolutionarily well-preserved protein present in the nucleolus and mitochondria of mammalian cells. We have previously reported that the pro-apoptotic activity of this protein is mediated by a characteristic cysteine-rich domain.
Ivan S de Melo +6 more
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ApaH diadenosine polyphosphatase from Legionella pneumophila
The FASEB Journal, 2013 The Nudix diadenosine polyphosphatase, NudA, is a virulence factor in Legionella pneumophila (LP), the causative agent of Legionnaires’ disease. The nonNudix diadenosine polyphosphatase, ApaH, is a virulence factor in E.
Michael Paul Madaio +7 more
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Ability of Polyphosphate and Nucleic Acids to Trigger Blood Clotting: Some Observations and Caveats
Frontiers in Medicine, 2018 Polyphosphate plays several roles in coagulation and inflammation, while extracellular DNA and RNA are implicated in thrombosis and as disease biomarkers.
Stephanie A. Smith +2 more
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Cells, 2019 Inorganic polyphosphate (polyP) is crucial for adaptive reactions and stress response in microorganisms. A convenient model to study the role of polyP in yeast is the Saccharomyces cerevisiae strain CRN/PPN1 that overexpresses polyphosphatase Ppn1 with ...
Ludmila Trilisenko +7 more
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A Comprehensive Lateral Flow Strip Assay for On-Site mRNA Vaccine Quality Control in Decentralized Manufacturing. [PDF]
Adv Sci (Weinh)A rapid, portable lateral flow strip assay for on‐site mRNA quality control is developed, enabling sequence‐independent analysis of 5' capping, integrity, and LNPs encapsulation efficiency. This cost‐effective method offers real‐time stability monitoring, reduced sample requirements, and comparable accuracy to standard techniques, enhancing ...
Luo D +9 more
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Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response
Cell Reports, 2021 Summary: Polyphosphate (polyP) is a polymer of hundreds of phosphate residues present in all organisms. In mammals, polyP is involved in crucial physiological processes, including coagulation, inflammation, and stress response.
Bàrbara Samper-Martín +14 more
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