The emerging landscape of eukaryotic polyphosphatases
FEBS Letters, 2023 Polyphosphate (polyP) is a conserved polymer of inorganic phosphate residues that can reach thousands of moieties in length. PolyP has been implicated in cellular functions ranging from energy and phosphate homeostasis to cell signalling in eukaryotes from yeast to humans.
Liam McCarthy, Michael Downey
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Polyphosphate-mediated inhibition of tartrate-resistant acid phosphatase and suppression of bone resorption of osteoclasts. [PDF]
PLoS ONE, 2013 Inorganic polyphosphate (poly(P)) has recently been found to play an important role in bone formation. In this study, we found that tartrate-resistant acid phosphatase (TRAP), which is abundantly expressed in osteoclasts, has polyphosphatase activity ...
Kana Harada +7 more
doaj +2 more sources
NOA36 protein contains a highly conserved nucleolar localization signal capable of directing functional proteins to the nucleolus, in mammalian cells. [PDF]
PLoS ONE, 2013 NOA36/ZNF330 is an evolutionarily well-preserved protein present in the nucleolus and mitochondria of mammalian cells. We have previously reported that the pro-apoptotic activity of this protein is mediated by a characteristic cysteine-rich domain.
Ivan S de Melo +6 more
doaj +3 more sources
Stress Resistance of Saccharomyces cerevisiae Strains Overexpressing Yeast Polyphosphatases [PDF]
Stresses, 2022 Inorganic polyphosphate (polyP) is an important factor in the stress resistance of microorganisms. The polyphosphate-overexpressing strains of yeast S.
Nadeshda Andreeva +4 more
doaj +2 more sources
Cells, 2019 Inorganic polyphosphate (polyP) is crucial for adaptive reactions and stress response in microorganisms. A convenient model to study the role of polyP in yeast is the Saccharomyces cerevisiae strain CRN/PPN1 that overexpresses polyphosphatase Ppn1 with ...
Ludmila Trilisenko +7 more
doaj +2 more sources
Ability of Polyphosphate and Nucleic Acids to Trigger Blood Clotting: Some Observations and Caveats
Frontiers in Medicine, 2018 Polyphosphate plays several roles in coagulation and inflammation, while extracellular DNA and RNA are implicated in thrombosis and as disease biomarkers.
Stephanie A. Smith +2 more
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A nucleotide metabolite controls stress-responsive gene expression and plant development.
PLoS ONE, 2011 Abiotic stress, such as drought and high salinity, activates a network of signaling cascades that lead to the expression of many stress-responsive genes in plants. The Arabidopsis FIERY1 (FRY1) protein is a negative regulator of stress and abscisic acid (
Hao Chen +3 more
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A Comprehensive Lateral Flow Strip Assay for On-Site mRNA Vaccine Quality Control in Decentralized Manufacturing. [PDF]
Adv Sci (Weinh)A rapid, portable lateral flow strip assay for on‐site mRNA quality control is developed, enabling sequence‐independent analysis of 5' capping, integrity, and LNPs encapsulation efficiency. This cost‐effective method offers real‐time stability monitoring, reduced sample requirements, and comparable accuracy to standard techniques, enhancing ...
Luo D +9 more
europepmc +2 more sources
Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response
Cell Reports, 2021 Summary: Polyphosphate (polyP) is a polymer of hundreds of phosphate residues present in all organisms. In mammals, polyP is involved in crucial physiological processes, including coagulation, inflammation, and stress response.
Bàrbara Samper-Martín +14 more
doaj +1 more source
Circular Photocaged mRNA for Light-induced Late-stage Activation of Translation. [PDF]
Angew Chem Int Ed EnglA clickable photo‐caged 5′ cap (CyCliCap) allows to make Cyclic Click Cap‐containing mRNA (CyCliCap‐mRNA) which is remarkably stable and translationally muted until irradiated, allowing for late‐stage activation of translation in cells by light. ABSTRACT mRNA is a new medical modality as vaccine and raises hopes to become a protein replacement agent ...
Terzi B +6 more
europepmc +2 more sources