Results 141 to 150 of about 1,357 (186)

Involvement of LncRNA FAF in chemotherapy-induced cardiotoxicity by mediating pyroptosis through modulation of the NLRP3-Caspase-1 signaling pathway. [PDF]

Sci Rep
Feng Z, Sun J, Geng Q, He B, Zhang J, Ainiwaer Y, Zhang B, Zhang Y.   +7 more
europepmc   +1 more source

Targeting the WNT/β-Catenin Pathway in Hematological Malignancies: From Molecular Pathogenesis to Emerging Therapeutic Strategies. [PDF]

Biomolecules
Keyhani A, Haddad Kashani H, Dizaji Asl K, Mazloumi Z, Kaikavoosnejad F, Ashraf Moosavi SS, Verdi M, Rafat A, Nejati R.   +8 more
europepmc   +1 more source

Antitumor effect of polyphyllin D on liver metastases of neuroblastoma

Antitumor effect of polyphyllin D on liver metastases of neuroblastoma
openaire   +1 more source

An Improved Synthesis of the Saponin, Polyphyllin D

Carbohydrate Research, 2001
Polyphyllin D, namely diosgenyl alpha-L-rhamnopyranosyl-(1 --> 2)- [(alpha-L-arabinofuranosyl)-(1 --> 4)]-[beta-D-glucopyranoside, was synthesized from diosgenyl-beta-D-glucopyranoside in four steps and in 30% overall yield, taking advantage of regioselective pivaloylation and alpha-L-rhamnopyranosylation reactions.
Kwok Pui Fung, Biao Yu, Xiuwen Han
exaly   +4 more sources

Synthesis of Three Diosgenyl Saponins: Dioscin, Polyphyllin D, and Balanitin 7

Carbohydrate Research, 1999
Dioscin, polyphyllin D, and balanitin 7, which belong to a group of structurally similar diosgenyl saponins with promising bioactivities, were synthesized by stepwise glycosylation.
Biao Yu, Xiuwen Han, Shaojiang Deng
exaly   +4 more sources

Molecular Mechanisms of Apoptosis in HepaRG Cell Line Induced by Polyphyllin VI via the Fas Death Pathway and Mitochondrial-Dependent Pathway

Toxins, 2018
Polyphyllin VI, which is an active saponin, is mainly isolated from traditional medicinal plant Paris polyphylla, which causes liver damage in rats. In the present study, we aimed to explore the potential cytotoxicity of polyphyllin VI on the growth of ...
Longtai You, Wenping Wang, Yi Liu
exaly   +2 more sources

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Pharmacokinetics profiles of polyphyllin II and polyphyllin VII in rats by liquid chromatography with tandem mass spectrometry

Biomedical Chromatography, 2021
AbstractPolyphyllin II (PII) and polyphyllin VII (PVII) are the main active ingredients in Paris Polyphylla with an excellent antitumor effect in vitro and in vivo. In this study, a rapid and precise LC–MS/MS method was developed and validated for the separation and simultaneous determination of PII and PVII in rat plasma, tissues, feces and urine ...
Genbei Wang, Ruijia Hao, Chen Luo, Yu Wang, Shuli Man, Wenyuan Gao   +5 more
openaire   +2 more sources

Molecular mechanisms of anticancer activities of polyphyllin VII

Chemical Biology & Drug Design, 2021
AbstractCancer is the leading cause of mortality in the world. The major therapies for cancer treatment are chemotherapy, surgery, and radiation therapy. All these therapies expensive, toxic and show resistance. The plant‐derived compounds are considered safe, cost‐effective and target cancer through different pathways.
Bashir Ahmad, Shafiq Ur Rehman, Azizullah Azizullah, Muhammad Fiaz Khan, Syed Riaz Ud Din, Manzoor Ahmad, Ashraf Ali, Naeem Tahir, Nasir Azam, Yaser Gamallat, Khalil Ur Rahman, Muhsin Ali, Mohammad Safi, Imran Khan, Samina Qamer, Deog‐Hwan Oh   +15 more
openaire   +2 more sources

Simultaneous determination and pharmacokinetic study of polyphyllin I, polyphyllin II, polyphyllin VI and polyphyllin VII in beagle dog plasma after oral administration of Rhizoma Paridis extracts by LC‐MS‐MS

Biomedical Chromatography, 2012
ABSTRACTFor the first time, a rapid and specific LC‐MS‐MS method has been developed for the analysis of polyphyllin I, polyphyllin II, polyphyllin VI and polyphyllin VII in beagle dog plasma. The method was applied to study the pharmacokinetics of Rhizoma Paridis extracts containing polyphyllin I, polyphyllin II, polyphyllin VI and polyphyllin VII. The
Xingbin, Yin, Changhai, Qu, Zhaoxia, Li, Yujing, Zhai, Sali, Cao, Longfei, Lin, Lijun, Feng, Lei, Yan, Jian, Ni   +8 more
openaire   +2 more sources

Polyphyllin D Is a Potent Apoptosis Inducer in Drug-Resistant HepG2 Cells

Cancer Letters, 2005
In a search for new anticancer agents, we identified a novel compound polyphyllin D (PD) (diosgenyl alpha-L-rhamnopyranosyl-(1-->2)-(alpha-L-arabinofuranosyl)-(1-->4)]-[beta-D-glucopyranoside) that induced DNA fragmentation and phosphatidyl-serine (PS) externalization in a hepatocellular carcinoma cell line HepG2 derivative with drug resistance (R ...
Biao Yu, Siu-Kai Kong, Kwok-Pui Fung
exaly   +3 more sources