Results 161 to 170 of about 1,357 (186)

A synergistic antitumor effect of polyphyllin I and formosanin C on hepatocarcinoma cells

Bioorganic & Medicinal Chemistry Letters, 2016
Polyphyllin I (PPI) and formosanin C (FC) were regarded as effective and imperative components isolated from Rhizoma Paridis saponins (RPS) and exhibited strong anti-tumor effects on a variety of cancers. With the wide application of complex mixtures in clinics, synergistic interactions are of vital importance in phytomedicine.
Jing Liu, Shuli Man, Zhen Liu, Long Ma, Wenyuan Gao   +4 more
openaire   +2 more sources

Two rhamnosyltransferases for de novo biosynthesis of polyphyllins in Nicotiana benthamiana

The Plant Journal
SUMMARYPolyphyllins, a prominent class of steroidal saponins in Paris species, owe their diverse bioactivities to their sugar unit configurations, though their glycosylation pathways remain poorly understood. Here, we identified and characterized two UDP‐rhamnosyltransferases, PpUGT73YD1 and PpUGT738A2, using heterologous expression systems.
Wei Song, Tong Li, Shan Yan, Mingyue Zhang, Xiaojing Ma, Liping Kang, Xin Hua, Zheyong Xue   +7 more
openaire   +2 more sources

Polyphyllin I in Malignant Tumors: Molecular Mechanisms and Recent Advances

BackgroundRhizoma Paridis (Chong-lou) is a widely used traditional Chinese medicine known for its effects in reducing swelling, relieving pain, and clearing heat and toxins. Modern pharmacological studies have confirmed that it possesses antibacterial, anti-inflammatory, analgesic, anticancer, and immunoregulatory properties.
Yiyan Zhai, Xiangli Yin, Zeyu Xue, Zijian Xu, Huiling Lei, Peiying Lu, Xiaodong Chen, Meiling Guo, Junyi Li, Muyassar Mamattohti, Xiaojing Zhao, Chunguo Wang, Jiarui Wu   +12 more
openaire   +1 more source

Structure‐Driven Mechanisms and Synergistic Approaches of Polyphyllin VII in Breast Cancer Therapy

Archiv der Pharmazie
ABSTRACT Polyphyllin VII (PP7), a natural saponin derived from the rhizomes of Paris polyphylla (family: Melanthiaceae), possesses a unique steroidal furostane structure that contributes to its versatile pharmacological profile.
Alaa O. Hamouda, Nadin H. Sarg, Sara I. Ibrahim, Rania Hamdy, Sameh S. M. Soliman, Hany A. Omar   +5 more
openaire   +2 more sources

polyphylline, adj.

2023
openaire   +1 more source

The Comparison Analysis of Polyphyllin I and Its Analogues Induced Apoptosis of Colon and Lung Cancer Cells via Mitochondrial Dysfunction

Basic and Clinical Pharmacology and Toxicology, 2021
Ming Lei, Guangbo Ge, Wangdandan Wang
exaly  

Polyphyllin I Reverses the Resistance of Osimertinib in Non-Small Cell Lung Cancer Cell Through Regulation of PI3K/Akt Signaling

Toxicology and Applied Pharmacology, 2021
Lai Jianjun, Zhibing Wu
exaly  

Polyphyllin D Induces Necroptosis in Neuroblastoma Cells (IMR-32 and LA-N-2) in Mice

Pediatric Surgery International, 2023
Shunsuke Watanabe, Mikihiro Inoue, Mika Murayama   +2 more
exaly  

Simultaneous Determination and Pharmacokinetic Study of Polyphyllin I, Polyphyllin II, Polyphyllin VI and Polyphyllin VII in Beagle Dog Plasma After Oral Administration of Rhizoma Paridis Extracts by LC-MS-MS

Biomedical Chromatography, 2013
Changhai Qu, Longfei Lin, Jian Ni
exaly  

Polyphyllin E

2006
openaire   +1 more source