Results 81 to 90 of about 1,853 (164)

Human immunodeficiency virus neutralizing antibodies and methods of use thereof [APPLICATION] [PDF]

, 2014
The invention provides broadly neutralizing antibodies directed to epitopes of Human Immunodeficiency Virus, or HIV. The invention further provides compositions containing HIV antibodies used for prophylaxis, and methods for diagnosis and treatment of ...
Bjorkman, Pamela J., Diskin, Ron, Nussenzweig, Michel, Scheid, Johannes   +3 more
core  

Epitop mapping of natural and disease associated autoantibodies againts topoisomerase I in systemic sclerosis and systemic lupus erythemathosus [PDF]

, 2010
5
Simon Diána
core  

Toll-Like Receptors and Cancer: MYD88 Mutation and Inflammation

, 2016
Pattern recognition receptors (PRRs) expressed on immune cells are crucial for the early detection of invading pathogens, in initiating early innate immune response and in orchestrating the adaptive immune response.
Ferguson, Laura L., Horikawa, Keisuke, Jeelall, Yogesh S., Wang, James Q.   +3 more
core   +1 more source

Anti-HLA antibodies may be a subset of polyreactive immunoglobulins generated after viral superinfection

Transplant Immunology
Chronic rejection remains an obstacle to long-term allograft survival. Donor-specific anti-HLA antibodies (DSA) play a significant role in causing chronic antibody-mediated allograft rejection. Exposure to mismatched HLA antigens via transfusion, pregnancy, or transplanted tissue has been described in the literature as an immunogenic stimulus of anti ...
Steven D, Heron, Jim, Shaw, Johannes, Dapprich   +2 more
openaire   +2 more sources

HIV-1 treatment timing shapes the human intestinal memory B-cell repertoire to commensal bacteria. [PDF]

Nat Commun, 2023
Planchais C, Molinos-Albert LM, Rosenbaum P, Hieu T, Kanyavuz A, Clermont D, Prazuck T, Lefrou L, Dimitrov JD, Hüe S, Hocqueloux L, Mouquet H.   +11 more
europepmc   +1 more source

Antigen-specific CD4+ T-B cell interplay induces a robust, polyreactive systemic immunoglobulin response to commensal bacteremia.

, 2020
The impact of cognate CD4+ T cell help on the systemic antibody response during commensal bacteremia was assessed in detail in this thesis. To specifically evaluate cognate T cell-B cell interactions, we utilized a genetically modified commensal E. coli strain that expressed gp61, an additional T helper epitope, in its outer membrane ompC protein (E ...
openaire   +2 more sources

Chickens, more than humans, focus the diversity of their immunoglobulin genes on the complementarity-determining region but utilise amino acids, indicative of a more cross-reactive antibody repertoire. [PDF]

Front Immunol, 2022
Mallaby J, Ng J, Stewart A, Sinclair E, Dunn-Walters D, Hershberg U.   +5 more
europepmc   +1 more source

CHARACTERIZING ECTOPARASITE DISEASE PRESSURE AND THE UTILITY OF ANTIBODY MARKERS FOR IMMUNE DEFENSE IN POULTRY [PDF]

Open-environment farms are increasingly popular alternatives to conventional caged poultry farms. However, poultry are at an increased risk of exposure to parasites and pathogens in these alternative farming systems, impacting poultry health and leading ...
Weston, Kendra
core   +2 more sources

Tn antigen and anti-Tn natural, polyreactive immunoglobulin M (IgM) arise as an evolutionary and functional unit, as seen in SARS-CoV-2 (COVID-19) infection

, 2023
The pathogenesis of SARS-CoV-2 disease may be characterized by a complex of genetically undefined N- and O-glycozylations, whereas trans-species O-GalNAc glycosylation or hybrid Tn formation has been identified as viral-host linkage, and exposed to preexisting evolutionary, germline-encoded anti-Tn/anti-A cross-reactive polyreactive IgM activity, is ...
openaire   +1 more source

Defining and Studying B Cell Receptor and TCR Interactions. [PDF]

J Immunol, 2023
Rappazzo CG, Fernández-Quintero ML, Mayer A, Wu NC, Greiff V, Guthmiller JJ.   +5 more
europepmc   +1 more source