Results 31 to 40 of about 1,913 (163)

cGAS/STING‐Independent Induction of Type I Interferon by Inhibitors of the Histone Methylase KDM5B

The FASEB Journal, Volume 39, Issue 9, 15 May 2025.
Mechanism of HEXIM1 regulation of Type I Interferon. ABSTRACT Studies support the role of hexamethylene bis‐acetamide [HMBA] induced protein 1 (HEXIM1) as a tumor suppressor. We previously reported that the histone demethylase, KDM5B, inhibits the expression of HEXIM1, and KDM5B inhibitors (KDM5Bi) upregulate HEXIM1 expression. As a consequence, KDM5Bi
Monica M. Montano, I‐Ju Yeh, Wannarasmi Ketchart   +2 more
wiley   +1 more source

Transcriptome atlas of Striga germination: Implications for managing an intractable parasitic plant

PLANTS, PEOPLE, PLANET, Volume 7, Issue 2, Page 396-410, March 2025.
Witchweeds, parasitic plants of the genus Striga, are nicknamed “cereal killers” because of their devastating destruction of Africa's most staple cereals, including maize, sorghum, millets, and upland rice. The parasite relies on biomolecules emitted from the host roots to germinate and therefore initiate its infectious lifecycle.
Gilles Irafasha, Sylvia Mutinda, Fredrick Mobegi, Brett Hale, George Omwenga, Asela J. Wijeratne, Susann Wicke, Emily S. Bellis, Steven Runo   +8 more
wiley   +1 more source

Spectroscopic studies on the structure of poly(8-bromoadenylic acid): effect of glycosidic torsion angle on the conformation and flexibility in polyribonucleotides

, 1976
The helix-coil transition and conformational structure of poly(8-bromoadenylic acid) [poly(8BrA)] have been investigated using 1H- and 13C-nmr, CD, and ir spectroscopy.
Todd Miles, H., Fisk, Cherie L., Howard, Frank B., Govil, Girjesh   +3 more
core   +1 more source

Heterozygous PNPT1 Variants Cause a Sensory Ataxic Neuropathy

European Journal of Neurology, Volume 32, Issue 2, February 2025.
ABSTRACT Background Biallelic variants in polyribonucleotide‐nucleotidyltransferase‐1 (PNPT1) have been associated with a range of phenotypes from syndromic hearing loss to Leigh's syndrome. More recently, heterozygous variants in PNPT1, have been reported in three families with cerebellar ataxia and prominent sensory neuropathy.
Saif Haddad, Christopher J. Record, Eleanor Self, Mariola Skorupinska, Alexander M. Rossor, Matilde Laura, Gordon Ingle, Adnan Manzur, Francesco Muntoni, Julian C. Blake, Mary M. Reilly   +10 more
wiley   +1 more source

The activity on double-stranded RNA of aggregates of ribonuclease A higher than dimers increases as a function of the size of the aggregates. [PDF]

, 1996
Stable bovine RNase A aggregates larger than dimers (identified as trimers, tetramers, pentamers and hexamers) were obtained by lyophilization of RNase A from 40-50% acetic acid solutions.
SORRENTINO, SALVATORE, S. Sorrentino, M. Bertoldi, M. Libonati, BERTOLDI M, LIBONATI M   +5 more
core   +1 more source

CT1812 biomarker signature from a meta‐analysis of CSF proteomic findings from two Phase 2 clinical trials in Alzheimer's disease

Alzheimer's &Dementia, Volume 20, Issue 10, Page 6860-6880, October 2024.
Abstract INTRODUCTION CT1812 is in clinical development for the treatment of Alzheimer's disease (AD). Cerebrospinal fluid (CSF) exploratory proteomics was employed to identify pharmacodynamic biomarkers of CT1812 in mild to moderate AD from two independent clinical trials.
Britney N. Lizama, Claire Williams, Hilary A. North, Kiran Pandey, Duc Duong, Valentina Di Caro, Adam P. Mecca, Kaj Blennow, Henrik Zetterberg, Allan I. Levey, Michael Grundman, Christopher H. van Dyck, Anthony O. Caggiano, Nicholas T. Seyfried, Mary E. Hamby   +14 more
wiley   +1 more source

Applications of Laser-Raman spectroscopy to the analysis of polynucleotides containing uridine residues

, 2013
Qualitative characterization of uridine C(2′)-endo-anti and C(3′)-endo-anti forms has been carried out for the first time using Laser-Raman spectroscopy. Spectra are presented for some crystals containing the uridine residue whose conformations are known
Escobar, R., Molina, M., Carmona, Pedro
core   +1 more source

High‐quality genome of a novel Thermosynechococcaceae species from Namibia and characterization of its protein expression patterns at elevated temperatures

MicrobiologyOpen, Volume 13, Issue 5, October 2024.
In this study, the genome of a new thermophilic cyanobacterium, Thermosynechococcaceae cyanobacterium sp. Okahandja, isolated from a hot spring near Okahandja in Namibia, was sequenced. Additionally, cultivations were conducted at elevated temperatures of 40, 50, and 55°C, followed by analyses of the respective adapted proteomes based on the annotated ...
Nathanael D. Arnold, Michael Paper, Tobias Fuchs, Nadim Ahmad, Patrick Jung, Michael Lakatos, Katia Rodewald, Bernhard Rieger, Farah Qoura, Martha Kandawa‐Schulz, Norbert Mehlmer, Thomas B. Brück   +11 more
wiley   +1 more source

5S RNA may not have highly ordered structure like 4S RNAS

, 1982
The rates of hydrolysis of the following polyribonucleotides as catalysed by RNase I, an enzyme specific for single stranded RNAs, follow the sequence shown; poly (A) > 23S RNA > 5S RNA »16S RNA > 4S RNA = poly (I)·poly (C).
Burma, D. P., Tewari, D. S.
core   +1 more source

Multilayered proteomics reveals that JAM‐A promotes breast cancer progression via regulation of amino acid transporter LAT1

Cancer Science, Volume 115, Issue 9, Page 3153-3168, September 2024.
We uncovered junctional adhesion molecule‐A (JAM‐A), one of the transmembrane‐type tight junction proteins (TJPs), promoted breast cancer progression via regulation of amino acid transporter LAT1 using multilayered proteomics. Our findings provide a new insight into a therapeutic strategy, JAM‐A‐targeted therapy ideally combined with LAT1‐targeted ...
Kazufumi Magara, Akira Takasawa, Kumi Takasawa, Tomoyuki Aoyama, Misaki Ota, Daisuke Kyuno, Yusuke Ono, Taro Murakami, Soh Yamamoto, Yuna Nakamori, Naoya Nakahashi, Goro Kutomi, Ichiro Takemasa, Tadashi Hasegawa, Makoto Osanai   +14 more
wiley   +1 more source