Results 31 to 40 of about 2,499 (191)

Exploring interaction modes between polysaccharide-based selectors and biologically active 4,4′-bipyridines by experimental and computational analysis

Journal of Chromatography Open, 2022
In the last few years, chiral 4,4′-bipyridine derivatives have been developed for different applications in catalysis, enantioseparation science, supramolecular and theoretical chemistry by modulating the activity of the molecular system through the ...
Roberto Dallocchio, Alessandro Dessì, Barbara Sechi, Bezhan Chankvetadze, Sergio Cossu, Victor Mamane, Emmanuel Aubert, Carla Rozzo, Giuseppe Palmieri, Ylenia Spissu, Paola Peluso   +10 more
doaj   +1 more source

Comparative Chiral Separation of Thalidomide Class of Drugs Using Polysaccharide-Type Stationary Phases with Emphasis on Elution Order and Hysteresis in Polar Organic Mode

Molecules, 2021
The enantioseparation of four phthalimide derivatives (thalidomide, pomalidomide, lenalidomide and apremilast) was investigated on five different polysaccharide-type stationary phases (Chiralpak AD, Chiralpak AS, Lux Amylose-2, Chiralcel OD and Chiralcel
Mohammadhassan Foroughbakhshfasaei, Máté Dobó, Francisc Boda, Zoltán-István Szabó, Gergő Tóth   +4 more
doaj   +1 more source

Preparative separation of ketoprofen enantiomers: choice of mobile phase composition and measurement of competitive adsorption isotherms [PDF]

, 2007
The present work intends to investigate how mobile phase composition influences the adsorption behavior of ketoprofen enantiomers (a nonsteroidal anti-inflammatory drug) on an amylose-based chiral stationary phase (Chiralpak AD).
Graça, Nuno S., Pais, Luís S., Ribeiro, António E., Rodrigues, Alírio   +3 more
core   +1 more source

Merging Biocatalysis and Chemocatalysis in Flow: State‐of‐the‐Art and Future Directions for Sustainable Synthesis

Angewandte Chemie, EarlyView.
This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Petros Siasiaridis, Matteo Damian, Francesco G. Mutti   +2 more
wiley   +2 more sources

Multigram synthesis and in vivo efficacy studies of a novel multitarget anti-Alzheimer's compound [PDF]

, 2015
We describe the multigram synthesis and in vivo efficacy studies of a donepezil‒huprine hybrid that has been found to display a promising in vitro multitarget profile of interest for the treatment of Alzheimer's disease (AD).
Brunner, Daniela, Camps García, Pelayo, Cassina, Matteo, Colantuono, Diego, Diomede, Luisa, Franco, Pilar, Galdeano Cantador, Carlos, Gómez Nadal, Tània, Hutter-Paier, Birgit, Muñoz-Torrero López-Ibarra, Diego, Robin, David, Romeo, Margherita, Salmona, Mario, Schaeffer, Mireille, Sola, Irene, Taub, Nicole, Viayna, Elisabet   +16 more
core   +3 more sources

Influence of Temperature on the Enantioselectivity of Koga Tetraamines on Amylose Chiral Stationary Phases

Molecules, 2013
Enantioseparation is largely based on the formation of transitional complexes, the solvation species, the stationary phase configurations or the diastereomeric complexes formed by analytes and the chiral stationary phase.
Hong-Xun Guo, Steven Wu, Jingshun Sun
doaj   +1 more source

Separation of 4-substituted 5-methylpiracetam stereoisomers on polysaccharide-based chiral stationary phases

Journal of Chromatography Open
Monitoring of stereoisomer content in samples containing chiral compounds with multiple chiral centers is an important and challenging task in chiral liquid chromatography.
H. Kažoka, B. Turovska, T. Upmanis
doaj   +1 more source

Optimization of mobile phase composition for preparative separation of profens enantiomers by chiral liquid chromatography [PDF]

, 2008
In this paper it will be presented and discussed the experimental and simulation results obtained for the preparative separation of ketoprofen and flurbiprofen enantiomers by chiral liquid chromatography.
Berger, Guido, Brandão, Diego, Castro, Gabriel G.R., Dias, João T., Lima, José, Pinto, Milena F., Silva, Yago M.R. da, Sousa, Lucas C., Souza, Caio L.   +8 more
core   +1 more source

Polysaccharide Derivatives as Unique Chiral Selectors for Enantioselective Chromatography

CHIMIA, 2017
From the beginning of the 1980s, the life science industry increasingly recognized the importance of chirality in biological interaction processes, but the methods for preparing optically pure drugs were still limited.
Eric R. Francotte
doaj   +1 more source

Eluent Tolerance and Enantioseparation Recovery of Chiral Packing Materials Based on Chitosan Bis(Phenylcarbamate)-(n-Octyl Urea)s for High Performance Liquid Chromatography

Molecules, 2016
The goal of the present work was to study the influence of the swelling of chitosan derivatives on the enantioseparation and the separation performance recovery of chiral stationary phases (CSPs) based on these derivatives.
Jing Wang, Shao-Hua Huang, Wei Chen, Zheng-Wu Bai   +3 more
doaj   +1 more source