Results 171 to 180 of about 484,847 (189)

Lack of neuronal NOS has consequences for the expression of POMC and POMC-derived peptides in the mouse pituitary

Acta Histochemica, 2001
The relevance of NO in neuroendocrine signalling has been investigated by analysis of cellular expression of pro-opiomelanocortin (POMC) and the POMC-derived peptides beta-endorphin, alpha-melanocyte stimulating hormone and adrenocorticotropin. Expression patterns were studied in the pituitary gland of 150-day old wild-type and neuronal-NOS (nNOS ...
G, Keilhoff, B, Seidel, M, Reiser, A, Stanarius, P L, Huang, B, Bogerts, G, Wolf, H G, Bernstein   +7 more
openaire   +2 more sources

PDK-1/FoxO1 pathway in POMC neurons regulatesPomcexpression and food intake

American Journal of Physiology-Endocrinology and Metabolism, 2010
Both insulin and leptin signaling converge on phosphatidylinositol 3-OH kinase [PI( 3 )K]/3-phosphoinositide-dependent protein kinase-1 (PDK-1)/protein kinase B (PKB, also known as Akt) in proopiomelanocortin (POMC) neurons. Forkhead box-containing protein-O1 (FoxO1) is inactivated in a PI( 3 )K-dependent manner.
Kristy, Iskandar, Yongheng, Cao, Yoshitake, Hayashi, Masanori, Nakata, Eisuke, Takano, Toshihiko, Yada, Changliang, Zhang, Wataru, Ogawa, Miyo, Oki, Streamson, Chua, Hiroshi, Itoh, Tetsuo, Noda, Masato, Kasuga, Jun, Nakae   +13 more
openaire   +2 more sources

POMC Neurons: Feeding, Energy Metabolism, and Beyond

2018
The central melanocortin system is a well-established neuronal pathway involved in regulating energy metabolism. Pro-opiomelanocortin (POMC) neurons, agouti gene-related protein (AgRP) neurons, and their downstream cells expressing the melanocortin-3 (MC3R) and melanocortin-4 receptors (MC4R) are three key components of the central melanocortin pathway.
openaire   +2 more sources

Estrogen Promotes Parvalbumin Expression in Arcuate Nucleus POMC Neurons

Reproductive Sciences, 2010
We have found that estrogen promotes suppression of feeding and a lean body mass while activating the arcuate nucleus proopiomelanocortin (POMC)-expressing neurons. These neurons, when activated, suppress appetite and increase energy expenditure. Because the increased activation of POMC neurons by estradiol was associated with increased glutamate ...
Peter, Sotonyi, Qian, Gao, Ingo, Bechmann, Tamas L, Horvath   +3 more
openaire   +2 more sources

Glycogen drives the sensory activation of POMC neurons

Nature Metabolism
Hypothalamic POMC neurons modulate systemic energy balance and glucose homeostasis by sensing nutritional state signals. In addition to this classic regulatory mode, these neurons are also activated by the sensory perception of food. Here, we report that food-related sensory cues engage glycogen metabolism in POMC neurons. Genetic depletion of glycogen
Alicia G. Gómez-Valadés, David Meseguer, Luís Varela, Gabriele Lienhard, Uxía Fernández, Andrés Vidal-Itriago, Miriam Toledo, Elena Eyre, Berta Laudo, Francisco Díaz-Castro, Macarena Pozo, Mehdi Boutagouga Boudjadja, Júlia Fos-Domènech, Pau García-Ramón, Mariana Ferreira, Jordi Altirriba, Daniel Beiroa, Bandy Chen, Amanda Rodríguez-Díaz, Maria Milà-Guasch, Iñigo Chivite, Arnaud Obri, Sara Ramírez, Roberta Haddad-Tóvolli, Iasim Tahiri, Mathew S. Gentry, Giuseppe D’Agostino, Rubén Nogueiras, Nicolas Renier, Tamas L. Horvath, Joan J. Guinovart, Jordi Duran, Marc Schneeberger, Marc Claret   +33 more
openaire   +2 more sources

Orexinergic innervation of POMC-containing neurons in the rat arcuate nucleus

Neuroreport, 2001
A pre-embedding double immunostaining technique was used to study the synaptic relationships between orexin-like immunoreactive axon terminals and preopiomelanocortin (POMC)-like immunoreactive neurons in the rat arcuate nucleus. Most of the synapses were axo-dendritic, while some axo-somatic synapses were also found.
J L, Guan, T, Saotome, Q P, Wang, H, Funahashi, T, Hori, S, Tanaka, S, Shioda   +6 more
openaire   +2 more sources

Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis

Cell Metabolism, 2021
Marc Schneeberger, Marc Claret, Luis Varela   +2 more
exaly  

Simultaneous targeting of POMC and AgRP neurons

Nature Metabolism
openaire   +2 more sources

Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control

Cell Metabolism, 2017
David Cano, Andrés Vidal-Itriago, Marc Schneeberger   +2 more
exaly  

Pro-opiomelanocortin (POMC) neuron translatome signatures underlying obesogenic gestational malprogramming in mice

Molecular Metabolism, 2020
Marc Claret, Jasmine Burguet, Arnaud Obri   +2 more
exaly