Results 161 to 170 of about 484,847 (189)
Cav3.1 is a leucine sensor in POMC neurons mediating appetite suppression and weight loss
Tsang AH +20 more
europepmc +1 more source
Functional heterogeneity of POMC neurons relies on mTORC1 signaling [PDF]
Cell Reports, 2021 Hypothalamic pro-opiomelanocortin (POMC) neurons are known to trigger satiety. However, these neuronal cells encompass heterogeneous subpopulations that release γ-aminobutyric acid (GABA), glutamate, or both neurotransmitters, whose functions are poorly ...
Wilfrid Mazier +2 more
exaly +9 more sources
DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons [PDF]
Cell Metabolism, 2017 Hypothalamic pro-opiomelanocortin (POMC) neurons regulate energy and glucose metabolism. Intracellular mechanisms that enable these neurons to respond to changes in metabolic environment are ill defined.
Chen Liu, Rosaria Meli, Hiromi Sesaki
exaly +6 more sources
Hypothalamic POMC neurons promote cannabinoid-induced feeding [PDF]
Nature, 2015 Hypothalamic pro-opiomelanocortin (POMC) neurons promote satiety. Cannabinoid receptor 1 (CB1R) is critical for the central regulation of food intake. Here we test whether CB1R-controlled feeding in sated mice is paralleled by decreased activity of POMC ...
Luis Varela +2 more
exaly +7 more sources
POMC Neurons: From Birth to Death [PDF]
Annual Review of Physiology, 2017 The hypothalamus is an evolutionarily conserved brain structure that regulates an organism's basic functions, such as homeostasis and reproduction. Several hypothalamic nuclei and neuronal circuits have been the focus of many studies seeking to understand their role in regulating these basic functions. Within the hypothalamic neuronal populations, the
Sabrina Diano +2 more
exaly +4 more sources
Loss of autophagy in hypothalamic POMC neurons impairs lipolysis [PDF]
EMBO Reports, 2012 Autophagy degrades cytoplasmic contents to achieve cellular homeostasis. We show that selective loss of autophagy in hypothalamic proopiomelanocortin (POMC) neurons decreases α-melanocyte-stimulating hormone (MSH) levels, promoting adiposity, impairing lipolysis and altering glucose homeostasis.
Rajat Singh +2 more
exaly +3 more sources
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Hypothalamic proopiomelanocortin (POMC) neurons have a cholinergic phenotype
European Journal of Neuroscience, 2006AbstractNeuronal networks originating in the hypothalamic arcuate nucleus play fundamental roles in the control of energy balance. Neuropeptide Y (NPY)‐producing neurons in the arcuate nucleus stimulate food intake, whereas arcuate nucleus neurons that release the proopiomelanocortin (POMC)‐derived peptide α‐melanocyte‐stimulating hormone (α‐MSH ...
Björn, Meister +5 more
openaire +2 more sources
An ATF4-ATG5 signaling in hypothalamic POMC neurons regulates obesity [PDF]
Autophagy, 2017 ATF4 (activating transcription factor 4) is an important transcription factor that has many biological functions, while its role in hypothalamic POMC (pro-opiomelanocortin-α) neurons in the regulation of energy homeostasis has not been explored. We recently discovered that mice with an Atf4 deletion specific to POMC neurons (PAKO mice) are lean and ...
Feifan Guo, Feifan Guo, Zhixue Liu
exaly +3 more sources
Mitochondrial regulation of obesity by POMC neurons
Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseasePro-opiomelanocortin (POMC) neurons, nestled in the hypothalamus, play a pivotal role in the intricate coordination of energy homeostasis and metabolic pathways. These neurons' mitochondria, often hailed as the cell's powerhouses, are crucial for maintaining cellular energy equilibrium and metabolic functionality.
Xing-Dan, Luo +5 more
openaire +2 more sources