Results 121 to 130 of about 9,907 (172)

Association of paraoxonase 1 (PON1) L55M and PON1 Q192R gene polymorphisms and risk of psoriasis

Giornale Italiano di Dermatologia e Venereologia, 2019
Although there have been significant advances for clarifying the pathogenesis of psoriasis, exact pathogenic mechanism of the disease is still unknown. Oxidative stress is considered to be a new etiopathogenetic key factor in the pathogenesis of psoriasis, as a result of the studies performing the association between psoriasis and paraoxonase 1 (PON1 ...
Akbas, Ali, SEÇKİN, HAVVA YILDIZ, KALKAN, GÖKNUR, Ogrum, Atiye, Pancar, Gunseli S., Bas, Yalcin, Ozyurt, Huseyin, Ates, Omer, Benli, Ismail   +8 more
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Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knockout mice

Free Radical Biology and Medicine, 2003
Human serum paraoxonase (PON1), an HDL-associated esterase, protects lipoproteins against oxidation, probably by hydrolyzing specific lipid peroxides. As arterial macrophages play a key role in oxidative stress in early atherogenesis, the aim of the present study was to examine the effect of PON1 on macrophage oxidative stress. For this purpose we used
Mira Rosenblat, Raymond Coleman
exaly   +3 more sources

Associations between paraoxonase 1 (PON1) polymorphisms and susceptibility and PON1 activity in rheumatoid arthritis patients, and comparison of PON1 activity in patients and controls: a meta-analysis

Clinical Rheumatology, 2019
We reviewed the associations between paraoxonase 1 (PON1) polymorphisms and susceptibility and PON1 activity in rheumatoid arthritis (RA) patients and compared PON1 activity between RA patients and controls.We conducted a meta-analysis of PON1 Q192R and L55M polymorphism and RA risk data and determined the associations between PON1 Q192R polymorphism ...
Young Ho Lee, Sang-Cheol Bae
exaly   +3 more sources

Paraoxonase‐1 (PON1) Status Analysis Using Non‐Organophosphate Substrates [PDF]

Current Protocols, 2021
Human paraoxonase-1 (PON1) is a high-density lipoprotein-associated enzyme with antioxidant, anti-inflammatory, and antiapoptotic roles. The ability of PON1 to hydrolyze specific organophosphate (OP) compounds and prevent accumulation of oxidized lipids ...
Lucio G Costa, Judit Marsillach, Clement Furlong   +2 more
exaly   +2 more sources

Serum paraoxonase (PON1) and its interactions with HDL: Relationship between PON1 and oxidative stress

, 2010
PON1 is a high density lipoprotein (HDL)-associated serum enzyme. Its primary function is to degrade commonly used insecticides and nerve gases. PON1 is found to be more effective than lecithin:cholesterol acyltransferase (LCAT) or apoA-I in protecting low density lipoproteins (LDL) against oxidation.
Vekić, Jelena, Kotur-Stevuljević, Jelena, Zeljković, Aleksandra, Stefanović, Aleksandra, Jelić-Ivanović, Zorana, Spasić, S, Spasojević-Kalimanovska, Vesna   +6 more
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Paraoxonase 1 (PON1) attenuates macrophage oxidative status: studies in PON1 transfected cells and in PON1 transgenic mice

Atherosclerosis, 2005
High density lipoprotein (HDL)-associated paraoxonase 1 (PON1), hydrolyzes oxidized lipids in oxidized low density lipoprotein (LDL) and thus protects against atherosclerosis development. Increased susceptibility to atherosclerosis observed in PON1 knockout (PON1(0)) mice was associated with increased LDL lipid peroxidation as well as increased ...
Orit, Rozenberg, Diana M, Shih, Michael, Aviram   +2 more
openaire   +2 more sources

PON1 gene polymorphisms and plasma PON1 activities in Takayasu's arteritis disease

Immunology Letters, 2013
Takayasu's arteritis (TA) is a chronic inflammation that affects the large vessels; however, its etiology is still unknown. Human serum paraoxonase hydrolyzes oxidized lipids into low-density lipoproteins and could therefore be associated with the prevalence of inflammation processes.
Claudia, Huesca-Gómez, María Elena, Soto, Vicente, Castrejón-Téllez, Oscar, Pérez-Méndez, Ricardo, Gamboa   +4 more
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Genetic Polymorphism in Paraoxonase 1 (PON1): Population Distribution of PON1 Activity

Journal of Toxicology and Environmental Health, Part B, 2009
Paraoxonase-1 (PON1) is a serum esterase that hydrolyzes the activated oxon form of several organophosphates. The central role of PON1 in detoxification of organophosphate (OP) pesticides was demonstrated in knockout mouse studies, suggesting that human variability in PON1 needs to be considered in health risk assessments involving exposure to these ...
Gary, Ginsberg, Patricia, Neafsey, Dale, Hattis, Kathryn Z, Guyton, Douglas O, Johns, Babasaheb, Sonawane   +5 more
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The PON1 gene and detoxication.

Neurotoxicology, 2001
It has been assumed since its discovery that serum paraoxonase (PON1) plays a major role in the detoxication of specific organophosphorus compounds. It was also assumed that individuals with low PON1 activity would be more susceptible to paraoxon/parathion poisoning than individuals with higher PON1 activity.
Furlong, C. E, Li, W. F, Brophy, V. H, Jarvik, G. P, Richter, R. J, Shih, D. M, Lusis, A. J, Costa, L. G.   +7 more
openaire   +2 more sources

Paraoxonase (Pon1) Q192R polymorphism and serum Pon1 activity in diabetic patients on maintenance hemodialysis

Clinical Nephrology, 2003
Patients with diabetic nephropathy have an increased risk of coronary heart disease (CHD). Paraoxonase (Pon1) is a high-density lipoprotein- (HDL) associated enzyme that protects low-density lipoprotein from oxidation and also protects against atherosclerosis.
B, Zhang, S, Eto, P, Fan, C, Bian, E, Shimoji, T, Saito, K, Saku   +6 more
openaire   +2 more sources