Results 141 to 150 of about 16,258 (219)

The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism

, 1999
In human populations, serum paraoxonase (PON1) exhibits a substrate dependent polymorphism. The Arg192 isoform hydrolyzes paraoxon rapidly but diazoxon, soman and especially sarin slowly.
Costa, L. G, Furlong, C. E., Lusis, A, Li, W. F, Richter, R. J, Shih, D. M   +5 more
core  

Paraoxonases as metabolic and signaling modulators: prospects for therapeutic and preventive implications. [PDF]

NPJ Metab Health Dis
Tehrani Fateh S, Tehrani Fateh S, Ziai SA.   +2 more
europepmc   +1 more source

Longstanding Transcriptional Activation of APOA1 and PON1 in Human Hepatocytes by CRISPR/dCas9 Technology: Transcriptomic Profile and Crosstalk with Endothelial Cells. [PDF]

Int J Mol Sci
Haratau JIC, Niculescu LS, Barbalata T, Sanda GM, Fuior EV, Sasson S, Sima AV, Stancu CS, Toma L.   +8 more
europepmc   +1 more source

Polygonum cuspidatum Exosome-Like Nanovesicles Alleviate Hypoxic Pulmonary Hypertension by Stabilizing PON1 to Inhibit MAPK-Mediated PASMC Phenotypic Switching. [PDF]

FASEB J
Chen B, Hu J, Pan X, Fan R, Chen C.
europepmc   +1 more source

Association of <i>PON1</i> Q192R/L55M Polymorphisms and Paraoxonase-1 levels with cardiometabolic risk in patients with type-2 diabetes mellitus. [PDF]

Pak J Med Sci
Ahmed AM, Al-Nakhle HH, Ashour K, Aljohani HM, Eltahir Z.   +4 more
europepmc   +1 more source

PON1 haplotypes show genotype-dependent associations with dysglycemia and metabolic liver risk beyond paraoxonase activity. [PDF]

Front Endocrinol (Lausanne)
Batista-Herrera L, Meneses MJ, Ribeiro RT, Gardete-Correia L, Raposo JF, Boavida JM, Penha-Gonçalves C, Macedo MP.   +7 more
europepmc   +1 more source

Genetic susceptibility to mercury in the amazon: A cross-sectional approach to snps analyses in exposed riverine populations. [PDF]

Genet Mol Biol
Lopes-Araújo A, Barthelemy JL, Arrifano GP, Santos-Sacramento L, Soares-Silva I, Leal-Nazaré CG, Lago-Pinheiro C, Macchi BM, Martín-Doimeadios RCR, Jiménez-Moreno M, Augusto-Oliveira M, Crespo-López ME.   +11 more
europepmc   +1 more source

The common variant Q192R at the paraoxonase 1 (PON1) gene and its activity are responsible for a portion of the altered antioxidant status in type 2 diabetes

Experimental biology and medicine, 2016
M. Zargari, Fahimeh Sharafeddin, A. Mahrooz, A. Alizadeh, Parisa Masoumi   +4 more
semanticscholar   +1 more source

Protecting Effects of Rutin and N-Acetyl Cysteine on PON1 Enzyme in Cyclosporine A-Treated Rats: An <i>In-Vivo, In-Vitro</i>, and <i>In-Silico</i> Study. [PDF]

Adv Biomed Res
Banisakin S, Abdizadeh T, Heidarian E, Saffari-Chaleshtori J.   +3 more
europepmc   +1 more source

Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress. [PDF]

Int J Mol Med
Xue M, Feng J, Mao X.
europepmc   +1 more source