Results 141 to 150 of about 6,713 (180)
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Bioorganic & Medicinal Chemistry, 2008
Paraoxonase1 (PON1) is a HDL bound enzyme and many of the anti-atherogenic properties of HDL are attributed to PON1. The enzyme precise mechanism of protective action and its endogenous substrate remain elusive. PON1 hydrolyzes organophosphates, arylesters and lactones, whereas the lactones activity is assumed as the physio/pathological one. This study
Hagai, Tavori +3 more
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Paraoxonase1 (PON1) is a HDL bound enzyme and many of the anti-atherogenic properties of HDL are attributed to PON1. The enzyme precise mechanism of protective action and its endogenous substrate remain elusive. PON1 hydrolyzes organophosphates, arylesters and lactones, whereas the lactones activity is assumed as the physio/pathological one. This study
Hagai, Tavori +3 more
openaire +2 more sources
Atherosclerosis, 2000
Human serum paraoxonase (PON1) is an esterase that has been shown to decrease the susceptibility of lipoproteins to lipid peroxidation. We found a polymorphism of cytosine/thymidine (-108C/T, the number is from the ATG codon) in the upstream region of the PON1 gene. The luciferase activity was lower in the -108T allele than in the -108C allele.
T, Suehiro +8 more
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Human serum paraoxonase (PON1) is an esterase that has been shown to decrease the susceptibility of lipoproteins to lipid peroxidation. We found a polymorphism of cytosine/thymidine (-108C/T, the number is from the ATG codon) in the upstream region of the PON1 gene. The luciferase activity was lower in the -108T allele than in the -108C allele.
T, Suehiro +8 more
openaire +2 more sources
Biochemical Genetics, 2012
PON1 and PON2 have attracted considerable attention as candidate genes for coronary heart disease because their enzymes function as key factors in lipoprotein catabolism pathways. We studied the distribution of PON1 and PON2 polymorphisms, including genotyping, lipid profile, and PON1 activity, and their association with PON1 activity and significant ...
Jihène, Rejeb +11 more
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PON1 and PON2 have attracted considerable attention as candidate genes for coronary heart disease because their enzymes function as key factors in lipoprotein catabolism pathways. We studied the distribution of PON1 and PON2 polymorphisms, including genotyping, lipid profile, and PON1 activity, and their association with PON1 activity and significant ...
Jihène, Rejeb +11 more
openaire +2 more sources
The active site of human paraoxonase (PON1)
Journal of Applied Toxicology, 2001Ideally we would like to treat people exposed to nerve agents with an enzyme that rapidly destroys nerve agents. The enzymes considered for such a role include human butyrylcholinesterase (BChE), acetylcholinesterase (AChE), carboxylesterase and paraoxonase (PON1).
D, Josse +5 more
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Pig PON1: Expression and promoter methylation
Gene Reports, 2018Abstract Atherosclerosis is an inflammatory disease promoted by oxidized low density lipoprotein (LDL). High density lipoprotein (HDL) is an important antioxidant, protecting LDL and itself from oxidation and by detoxifying the hydroperoxides from oxidized LDL.
Larsen, Knud Erik +2 more
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Acta neurologica Taiwanica, 2020
Various numbers of factors such as oxidative stress, neurotoxins, and pesticides have been implicated in its pathophysiology of Parkinson's disease (PD). Paraoxonas1 (PON1) metabolizes xenobiotics, including pesticides. Therefore, we surveyed the relationship between PON1 polymorphisms with its activities in the pathogenesis of Parkinson's disease..We ...
Ali, Mota +7 more
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Various numbers of factors such as oxidative stress, neurotoxins, and pesticides have been implicated in its pathophysiology of Parkinson's disease (PD). Paraoxonas1 (PON1) metabolizes xenobiotics, including pesticides. Therefore, we surveyed the relationship between PON1 polymorphisms with its activities in the pathogenesis of Parkinson's disease..We ...
Ali, Mota +7 more
openaire +1 more source
2002
The initial research on serum paraoxonase (PON1) centered on its ability to hydrolyze arylesters such as phenylacetate organophosphorus and compounds such as paraoxon, from whence it received its name. Despite early evidence that paraoxon and phenylacetate were hydrolyzed by the same enzyme, it was many years before all of the various research groups ...
Lucio G. Costa, Clement E. Furlong
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The initial research on serum paraoxonase (PON1) centered on its ability to hydrolyze arylesters such as phenylacetate organophosphorus and compounds such as paraoxon, from whence it received its name. Despite early evidence that paraoxon and phenylacetate were hydrolyzed by the same enzyme, it was many years before all of the various research groups ...
Lucio G. Costa, Clement E. Furlong
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Polymorphisms in the human paraoxonase (PON1) promoter
Pharmacogenetics, 2001Paraoxonase (PON1) is a protein component of high-density lipoprotein (HDL) particles that protects against oxidative damage to both low-density lipoprotein and HDL and detoxifies organophosphorus pesticides and nerve agents. A wide range of expression levels of PON1 among individuals has been observed.
V H, Brophy +5 more
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Pharmacogenetics, 2003
Paraoxonase (PON1) has been termed an environmental response enzyme for its function in the detoxification of organophosphate pesticides, nerve agents and pharmaceuticals such as glucocorticoids and statins, as well as its cardioprotective role in breaking down oxidized LDL.
Gail P, Jarvik +6 more
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Paraoxonase (PON1) has been termed an environmental response enzyme for its function in the detoxification of organophosphate pesticides, nerve agents and pharmaceuticals such as glucocorticoids and statins, as well as its cardioprotective role in breaking down oxidized LDL.
Gail P, Jarvik +6 more
openaire +2 more sources
2002
Paraoxonase (PON1) hydrolyzes a great number of toxic organophosphorus compounds (OP) and uncharged esters of acetic acid and aromatic alcohols. No selective substrate and no standard assay method exist for PON1. Therefore strong definition criteria have to be applied to distinguish PON1 from other OP-detoxicating enzymes.
Ronald Zech, Jörg M. Chemnitius
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Paraoxonase (PON1) hydrolyzes a great number of toxic organophosphorus compounds (OP) and uncharged esters of acetic acid and aromatic alcohols. No selective substrate and no standard assay method exist for PON1. Therefore strong definition criteria have to be applied to distinguish PON1 from other OP-detoxicating enzymes.
Ronald Zech, Jörg M. Chemnitius
openaire +1 more source