Results 141 to 150 of about 9,907 (172)
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Reproductive Toxicology, 2012
The purpose of the present study was to determine changes in plasma paraoxonase-1 activity (an indicator of paraoxonase phenotype) throughout normal pregnancy and its relationship with maternal oxidative stress status. The frequencies of the paraoxonase-1 phenotype in the studied population were determined using a two-substrate (paraoxon/diazoxon ...
Stefanović, Aleksandra +9 more
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The purpose of the present study was to determine changes in plasma paraoxonase-1 activity (an indicator of paraoxonase phenotype) throughout normal pregnancy and its relationship with maternal oxidative stress status. The frequencies of the paraoxonase-1 phenotype in the studied population were determined using a two-substrate (paraoxon/diazoxon ...
Stefanović, Aleksandra +9 more
openaire +4 more sources
Pharmacogenetics, 2003
Paraoxonase (PON1) has been termed an environmental response enzyme for its function in the detoxification of organophosphate pesticides, nerve agents and pharmaceuticals such as glucocorticoids and statins, as well as its cardioprotective role in breaking down oxidized LDL.
Gail P, Jarvik +6 more
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Paraoxonase (PON1) has been termed an environmental response enzyme for its function in the detoxification of organophosphate pesticides, nerve agents and pharmaceuticals such as glucocorticoids and statins, as well as its cardioprotective role in breaking down oxidized LDL.
Gail P, Jarvik +6 more
openaire +2 more sources
Acta neurologica Taiwanica, 2020
Various numbers of factors such as oxidative stress, neurotoxins, and pesticides have been implicated in its pathophysiology of Parkinson's disease (PD). Paraoxonas1 (PON1) metabolizes xenobiotics, including pesticides. Therefore, we surveyed the relationship between PON1 polymorphisms with its activities in the pathogenesis of Parkinson's disease..We ...
Ali, Mota +7 more
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Various numbers of factors such as oxidative stress, neurotoxins, and pesticides have been implicated in its pathophysiology of Parkinson's disease (PD). Paraoxonas1 (PON1) metabolizes xenobiotics, including pesticides. Therefore, we surveyed the relationship between PON1 polymorphisms with its activities in the pathogenesis of Parkinson's disease..We ...
Ali, Mota +7 more
openaire +1 more source
Drug Metabolism and Disposition, 2007
Phosphorothioate pesticides (OP) such as diazinon, chlorpyrifos, and parathion are activated to highly toxic oxon metabolites by the cytochromes P450 (P450s), mainly in the liver. Simultaneously, the P450s catalyze detoxification of OP to nontoxic dearylated metabolites.
Mutch E, Daly AK, Williams FM
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Phosphorothioate pesticides (OP) such as diazinon, chlorpyrifos, and parathion are activated to highly toxic oxon metabolites by the cytochromes P450 (P450s), mainly in the liver. Simultaneously, the P450s catalyze detoxification of OP to nontoxic dearylated metabolites.
Mutch E, Daly AK, Williams FM
openaire +3 more sources
2021
?????????????? ???????????????????? ?? 109 ?????????????????????? ???????????????? ?????????????? ??. ????????????????. ?????????????? ???????????? Q ???????? ???????????????????????? ?????????? ???????????????? ?????????????? ???????????????????? 0,67; ?????????????? ???????????? R ??? 0,33. ?????????????????????????? ?????????????????? ??????????????
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?????????????? ???????????????????? ?? 109 ?????????????????????? ???????????????? ?????????????? ??. ????????????????. ?????????????? ???????????? Q ???????? ???????????????????????? ?????????? ???????????????? ?????????????? ???????????????????? 0,67; ?????????????? ???????????? R ??? 0,33. ?????????????????????????? ?????????????????? ??????????????
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Polymorphisms in the human paraoxonase (PON1) promoter
Pharmacogenetics, 2001Paraoxonase (PON1) is a protein component of high-density lipoprotein (HDL) particles that protects against oxidative damage to both low-density lipoprotein and HDL and detoxifies organophosphorus pesticides and nerve agents. A wide range of expression levels of PON1 among individuals has been observed.
V H, Brophy +5 more
openaire +2 more sources
2013
Shown no statistically significant differences of functional polymorphisms of genes PON1 and FTO in the determination of the risk of obesity in school-age children. The presence of abnormally burdened alleles does not significantly affect the distribution of body fat mass for healthy children, but there is direct strong correlation between neck ...
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Shown no statistically significant differences of functional polymorphisms of genes PON1 and FTO in the determination of the risk of obesity in school-age children. The presence of abnormally burdened alleles does not significantly affect the distribution of body fat mass for healthy children, but there is direct strong correlation between neck ...
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Age-Related Alterations in PON1
2007Aging is associated with an increased incidence of atherosclerosis. Atherosclerosis is an inflammatory disease initiated by oxidized low density lipoprotein (oxLDL). High density lipoprotein (HDL) is a powerful antioxidant protecting LDL and itself from oxidation as well by detoxifying the hydroperoxides from oxLDL.
I. Seres, T. Fulop, G. Paragh, A. Khalil
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Paraoxonase (PON1) Gene Polymorphisms
2004COSTA, Lucio Guido, FURLONG C. E.
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