Results 131 to 140 of about 9,907 (172)

PON1 and Organophosphate Toxicity

2002
Early studies on different human populations showed that the hydrolytic activity of serum paraoxonase (PON1) was polymorphically distributed, raising the hypothesis that individuals with low PON1 activity may be at higher risk from toxic effects due to exposure to organophosphorus (OP) insecticides.
Lucio G. Costa, Wan-Fen Li, Rebecca J. Richter, Diana M. Shih, Aldons J. Lusis, Clement E. Furlong   +5 more
openaire   +1 more source

PON1 in Other Diseases

2002
HDL-associated paraoxonase (PON1) hydrolyses proinflammatory oxidized lipids, therefore blunting the inflammatory response. Increased oxidative stress leading to inflammation is involved in the etiology of several diseases, such as diabetes mellitus, atherosclerosis and a number of neurological disorders.
Bharti Mackness, Paul N. Durrington, Michael I. Mackness   +2 more
openaire   +1 more source

Association of PON1 and PON2 Polymorphisms with PON1 Activity and Significant Coronary Stenosis in a Tunisian Population

Biochemical Genetics, 2012
PON1 and PON2 have attracted considerable attention as candidate genes for coronary heart disease because their enzymes function as key factors in lipoprotein catabolism pathways. We studied the distribution of PON1 and PON2 polymorphisms, including genotyping, lipid profile, and PON1 activity, and their association with PON1 activity and significant ...
Jihène, Rejeb, Asma, Omezzine, Lamia, Rebhi, Imen, Boumaiza, Hajer, Mabrouk, Hamida, Rhif, Nabila Ben, Rejeb, Naoufel, Nabli, Wahiba, Douki, Ahmed Ben, Abdelaziz, Essia, Boughzala, Ali, Bouslama   +11 more
openaire   +2 more sources

PON1 in Different Species

2002
Paraoxonase (PON1) hydrolyzes a great number of toxic organophosphorus compounds (OP) and uncharged esters of acetic acid and aromatic alcohols. No selective substrate and no standard assay method exist for PON1. Therefore strong definition criteria have to be applied to distinguish PON1 from other OP-detoxicating enzymes.
Ronald Zech, Jörg M. Chemnitius
openaire   +1 more source

Association between PON1 5′-regulatory region polymorphisms, PON1 activity and ischemic stroke

Clinical Biochemistry, 2009
Paraoxonase I (PON1) was known as a risk factor for cerebrovascular diseases. This study assessed the association of single nucleotide polymorphisms (SNPs) in the PON1 5'-regulatory region with ischemic stroke and serum PON1 activity.Study subjects consisted of 418 healthy controls and 86 ischemic stroke patients with small vessel occlusion.
No Soo, Kim, Byoung Kab, Kang, Min Ho, Cha, Se-Mi, Oh, Mi Mi, Ko, Ok-Sun, Bang   +5 more
openaire   +2 more sources

Characterization of the PON1 active site using modeling simulation, in relation to PON1 lactonase activity

Bioorganic & Medicinal Chemistry, 2008
Paraoxonase1 (PON1) is a HDL bound enzyme and many of the anti-atherogenic properties of HDL are attributed to PON1. The enzyme precise mechanism of protective action and its endogenous substrate remain elusive. PON1 hydrolyzes organophosphates, arylesters and lactones, whereas the lactones activity is assumed as the physio/pathological one. This study
Hagai, Tavori, Soliman, Khatib, Michael, Aviram, Jacob, Vaya   +3 more
openaire   +2 more sources

A polymorphism upstream from the human paraoxonase (PON1) gene and its association with PON1 expression

Atherosclerosis, 2000
Human serum paraoxonase (PON1) is an esterase that has been shown to decrease the susceptibility of lipoproteins to lipid peroxidation. We found a polymorphism of cytosine/thymidine (-108C/T, the number is from the ATG codon) in the upstream region of the PON1 gene. The luciferase activity was lower in the -108T allele than in the -108C allele.
T, Suehiro, T, Nakamura, M, Inoue, T, Shiinoki, Y, Ikeda, Y, Kumon, M, Shindo, H, Tanaka, K, Hashimoto   +8 more
openaire   +2 more sources

Pig PON1: Expression and promoter methylation

Gene Reports, 2018
Abstract Atherosclerosis is an inflammatory disease promoted by oxidized low density lipoprotein (LDL). High density lipoprotein (HDL) is an important antioxidant, protecting LDL and itself from oxidation and by detoxifying the hydroperoxides from oxidized LDL.
Larsen, Knud Erik, Farajzadeh, Leila, Kristensen, Kaja Kjaer   +2 more
openaire   +2 more sources

The active site of human paraoxonase (PON1)

Journal of Applied Toxicology, 2001
Ideally we would like to treat people exposed to nerve agents with an enzyme that rapidly destroys nerve agents. The enzymes considered for such a role include human butyrylcholinesterase (BChE), acetylcholinesterase (AChE), carboxylesterase and paraoxonase (PON1).
D, Josse, O, Lockridge, W, Xie, C F, Bartels, L M, Schopfer, P, Masson   +5 more
openaire   +2 more sources

Perspectives in PON1 Research

2002
The initial research on serum paraoxonase (PON1) centered on its ability to hydrolyze arylesters such as phenylacetate organophosphorus and compounds such as paraoxon, from whence it received its name. Despite early evidence that paraoxon and phenylacetate were hydrolyzed by the same enzyme, it was many years before all of the various research groups ...
Lucio G. Costa, Clement E. Furlong
openaire   +1 more source