Results 131 to 140 of about 6,713 (180)

Genetic Polymorphism in Paraoxonase 1 (PON1): Population Distribution of PON1 Activity

Journal of Toxicology and Environmental Health, Part B, 2009
Paraoxonase-1 (PON1) is a serum esterase that hydrolyzes the activated oxon form of several organophosphates. The central role of PON1 in detoxification of organophosphate (OP) pesticides was demonstrated in knockout mouse studies, suggesting that human variability in PON1 needs to be considered in health risk assessments involving exposure to these ...
Gary, Ginsberg, Patricia, Neafsey, Dale, Hattis, Kathryn Z, Guyton, Douglas O, Johns, Babasaheb, Sonawane   +5 more
openaire   +2 more sources

Paraoxonase 1 (PON1) attenuates macrophage oxidative status: studies in PON1 transfected cells and in PON1 transgenic mice

Atherosclerosis, 2005
High density lipoprotein (HDL)-associated paraoxonase 1 (PON1), hydrolyzes oxidized lipids in oxidized low density lipoprotein (LDL) and thus protects against atherosclerosis development. Increased susceptibility to atherosclerosis observed in PON1 knockout (PON1(0)) mice was associated with increased LDL lipid peroxidation as well as increased ...
Orit, Rozenberg, Diana M, Shih, Michael, Aviram   +2 more
openaire   +2 more sources

PON1 gene polymorphisms and plasma PON1 activities in Takayasu's arteritis disease

Immunology Letters, 2013
Takayasu's arteritis (TA) is a chronic inflammation that affects the large vessels; however, its etiology is still unknown. Human serum paraoxonase hydrolyzes oxidized lipids into low-density lipoproteins and could therefore be associated with the prevalence of inflammation processes.
Claudia, Huesca-Gómez, María Elena, Soto, Vicente, Castrejón-Téllez, Oscar, Pérez-Méndez, Ricardo, Gamboa   +4 more
openaire   +2 more sources

Modulation of paraoxonase (PON1) activity

Biochemical Pharmacology, 2005
Paraoxonase 1 (PON1) is a serum enzyme closely associated with high density lipoprotein (HDL). PON1 hydrolyzes several organophosphorus compounds used as insecticides, as well as nerve agents; it metabolizes toxic oxidized lipids associated with both low density lipoprotein (LDL) and HDL; and it can hydrolyze a number of lactone-containing ...
COSTA L., VITALONE A., COLE T. B., COSTA, Lucio Guido   +3 more
openaire   +5 more sources

The PON1 gene and detoxication.

Neurotoxicology, 2001
It has been assumed since its discovery that serum paraoxonase (PON1) plays a major role in the detoxication of specific organophosphorus compounds. It was also assumed that individuals with low PON1 activity would be more susceptible to paraoxon/parathion poisoning than individuals with higher PON1 activity.
Furlong, C. E, Li, W. F, Brophy, V. H, Jarvik, G. P, Richter, R. J, Shih, D. M, Lusis, A. J, Costa, L. G.   +7 more
openaire   +2 more sources

Paraoxonase (Pon1) Q192R polymorphism and serum Pon1 activity in diabetic patients on maintenance hemodialysis

Clinical Nephrology, 2003
Patients with diabetic nephropathy have an increased risk of coronary heart disease (CHD). Paraoxonase (Pon1) is a high-density lipoprotein- (HDL) associated enzyme that protects low-density lipoprotein from oxidation and also protects against atherosclerosis.
B, Zhang, S, Eto, P, Fan, C, Bian, E, Shimoji, T, Saito, K, Saku   +6 more
openaire   +2 more sources

PON1 and Organophosphate Toxicity

2002
Early studies on different human populations showed that the hydrolytic activity of serum paraoxonase (PON1) was polymorphically distributed, raising the hypothesis that individuals with low PON1 activity may be at higher risk from toxic effects due to exposure to organophosphorus (OP) insecticides.
Lucio G. Costa, Wan-Fen Li, Rebecca J. Richter, Diana M. Shih, Aldons J. Lusis, Clement E. Furlong   +5 more
openaire   +1 more source

Association between PON1 5′-regulatory region polymorphisms, PON1 activity and ischemic stroke

Clinical Biochemistry, 2009
Paraoxonase I (PON1) was known as a risk factor for cerebrovascular diseases. This study assessed the association of single nucleotide polymorphisms (SNPs) in the PON1 5'-regulatory region with ischemic stroke and serum PON1 activity.Study subjects consisted of 418 healthy controls and 86 ischemic stroke patients with small vessel occlusion.
No Soo, Kim, Byoung Kab, Kang, Min Ho, Cha, Se-Mi, Oh, Mi Mi, Ko, Ok-Sun, Bang   +5 more
openaire   +2 more sources

PON1 in Other Diseases

2002
HDL-associated paraoxonase (PON1) hydrolyses proinflammatory oxidized lipids, therefore blunting the inflammatory response. Increased oxidative stress leading to inflammation is involved in the etiology of several diseases, such as diabetes mellitus, atherosclerosis and a number of neurological disorders.
Bharti Mackness, Paul N. Durrington, Michael I. Mackness   +2 more
openaire   +1 more source

Association of paraoxonase 1 (PON1) L55M and PON1 Q192R gene polymorphisms and risk of psoriasis

Giornale Italiano di Dermatologia e Venereologia, 2019
Although there have been significant advances for clarifying the pathogenesis of psoriasis, exact pathogenic mechanism of the disease is still unknown. Oxidative stress is considered to be a new etiopathogenetic key factor in the pathogenesis of psoriasis, as a result of the studies performing the association between psoriasis and paraoxonase 1 (PON1 ...
Akbas, Ali, SEÇKİN, HAVVA YILDIZ, KALKAN, GÖKNUR, Ogrum, Atiye, Pancar, Gunseli S., Bas, Yalcin, Ozyurt, Huseyin, Ates, Omer, Benli, Ismail   +8 more
openaire   +3 more sources