Results 151 to 160 of about 1,603 (207)

Recent advances in systemic therapy for advanced biliary tract cancer: A systematic review and meta-analysis using reconstructed RCT survival data. [PDF]

JHEP Rep
Li Z, Aliseda D, Jones O, Rajendran L, Magyar C, Grant R, O'Kane GM, Saborowski A, Sapisochin G, Vogel A.   +9 more
europepmc   +1 more source

Partial likelihood estimation of isotonic proportional hazards models. [PDF]

Biometrika, 2018
Chung Y, Ivanova A, Hudgens MG, Fine JP.
europepmc   +1 more source

A robust Bayesian dose optimization design with backfill and randomization for phase I/II clinical trials. [PDF]

Stat Methods Med Res
Qiu Y, Li M.
europepmc   +1 more source

Changes in motor unit conduction velocity after unilateral lower‐limb suspension and active recovery are correlated with muscle ion channel gene expression

Experimental Physiology, EarlyView.
Abstract The effects of muscle disuse on the propagation of action potentials along motor unit (MU) muscle fibres, a key process for effective muscle activation and force generation, remain poorly understood. The aim of this study was to investigate changes in action potential propagation and to identify biological factors influencing these changes ...
Giacomo Valli, Fabio Sarto, Francesco Negro, Elena Monti, Giuseppe Sirago, Matteo Paganini, Sandra Zampieri, Martino V. Franchi, Andrea Casolo, Julián Candia, Luigi Ferrucci, Marco V. Narici, Giuseppe De Vito   +12 more
wiley   +1 more source

A deep learning‐enabled toolkit for the 3D segmentation of ventricular cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend 3D cardiomyocyte segmentation enables comprehensive analyses of myocardial microstructure in health and disease; however, it is technically demanding. We present an open‐source toolkit for this task, which reduces challenges associated with sample preparation, image restoration, segmentation and proofreading.
Joachim Greiner, Fabio Frangiamore, Frédéric Sonak, Josef Madl, Thomas Seidel, Peter Kohl, Eva A. Rog‐Zielinska   +6 more
wiley   +1 more source

Noise‐induced reduction and early recovery of superior paraolivary nucleus sound‐offset responses

The Journal of Physiology, EarlyView.
Abstract figure legend Acoustic over‐exposure transiently disrupts auditory temporal processing in mouse superior paraolivary nucleus neurons. In control conditions, neurons exhibit robust sound‐offset (OFF) responses, which are abolished immediately following noise trauma, indicating impaired temporal encoding.
Mihai Stancu, Ezhilarasan Rajaram, Joseph A. Kroeger, Benedikt Grothe, Conny Kopp‐Scheinpflug   +4 more
wiley   +1 more source

Spinal motor neuron pools may be partly driven by impulsive common inputs

The Journal of Physiology, EarlyView.
Abstract figure legend A schematic overview of the proposed motor neuron drive framework. Unlike the traditionally assumed continuous common input (cCI), we propose that impulsive common inputs (iCI) constitute a key driver of motor neuron (MN) pool activity.
Javier Yanguas Mayo, Alejandro Pascual Valdunciel, Stuart N Baker, Pablo Laguna, Dario Farina, Jaime Ibáñez Pereda   +5 more
wiley   +1 more source

Exploiting fluctuations in gene expression to detect causal interactions between genes. [PDF]

Elife
Joly-Smith E, Talpur MM, Allard P, Papazotos F, Potvin-Trottier L, Hilfinger A.   +5 more
europepmc   +1 more source

A novel dual‐decomposition method for non‐convex two‐stage stochastic mixed‐integer quadratically constrained quadratic problems

International Transactions in Operational Research, Volume 33, Issue 5, Page 3128-3157, September 2026.
Abstract We propose the novel p‐branch‐and‐bound method for solving two‐stage stochastic programming problems whose deterministic equivalents are represented by non‐convex mixed‐integer quadratically constrained quadratic programming (MIQCQP) models. The precision of the solution generated by the p‐branch‐and‐bound method can be arbitrarily adjusted by
Nikita Belyak, Fabricio Oliveira
wiley   +1 more source

Doctoral Problems and Taboos: Silence, Well‐Being and Academic Persistence in Czech Doctoral Education

Higher Education Quarterly, Volume 80, Issue 3, July 2026.
ABSTRACT This paper examines how the taboos and problems perceived by doctoral students are associated with their well‐being and their intentions to persist in or leave academia. We distinguish between doctoral problems—stressors associated with doctoral study—and doctoral taboos, understood as issues that remain difficult to voice in relationships ...
Tomáš Lintner, Karla Brücknerová, Barbora Nekardová, Jana Navrátilová, Jakub Vlček, Kristýna Šejnohová, Boglárka Belovecová   +6 more
wiley   +1 more source