Results 151 to 160 of about 145,891 (201)

From Inclusion Complexes to Innovative Therapies: Cyclodextrins and Their Pharmaceutical Applications. [PDF]

Pharmaceutics
Trasca DM, Pirscoveanu DFV, Varut RM, Pluta ID, Stoica GA.   +4 more
europepmc   +1 more source

Biphasic dissolving microneedles with cyclodextrin inclusion complexes for enhanced delivery of poorly soluble drugs. [PDF]

RSC Adv
Wang R, Cao J, Zou J, Zhang R, Li M, Zhang W, Guo M.   +6 more
europepmc   +1 more source

Mutual solubilization of rosiglitazone and ibuprofen: Investigation and mechanistic insight. [PDF]

PLoS One
Gong Y, Liu W.
europepmc   +1 more source

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Microgels and Nanogels for the Delivery of Poorly Water-Soluble Drugs

Molecular Pharmaceutics, 2022
While microgels and nanogels are most commonly used for the delivery of hydrophilic therapeutics, the water-swollen structure, size, deformability, colloidal stability, functionality, and physicochemical tunability of microgels can also offer benefits for addressing many of the barriers of conventional vehicles for the delivery of hydrophobic ...
Ridhdhi Dave, Gurpreet Randhawa, Daeun Kim, Madeline Simpson, Todd Hoare   +4 more
openaire   +2 more sources

Nanoprecipitation for Poorly Water-Soluble Drugs

Current Drug Metabolism, 2018
More than 60% of the active pharmaceutical ingredients, which are classified as Biopharmaceutics Classification System class II. The limited solubility of these drug may lead to low therapeutic effects.Nanoprecipitation presents some advantages because it is a straightforward method with low-cost equipment that is easy to scale up.However, there are ...
Tuong N G, Nguyen, Van-Thanh, Tran, Wei, Duan, Phuong H L, Tran, Thao T D, Tran   +4 more
openaire   +2 more sources

Nanonization strategies for poorly water-soluble drugs

Drug Discovery Today, 2011
Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor(®) EL).
Huabing, Chen, Chalermchai, Khemtong, Xiangliang, Yang, Xueling, Chang, Jinming, Gao   +4 more
openaire   +2 more sources

Hydrotropic Solubilization of Poorly Water-Soluble Drugs

Journal of Pharmaceutical Sciences, 2010
The solubilizing ability of two aromatic hydrotropes, N,N-diethylnicotinamide (DENA) and N,N-dimethylbenzamide (DMBA), was investigated using a set of 13 poorly soluble, structurally diverse drugs. The number of aromatic rings in the solute molecule has a very strong effect on the solubility enhancement produced by either hydrotrope.
Ji Young, Kim, Sungwon, Kim, Michelle, Papp, Kinam, Park, Rodolfo, Pinal   +4 more
openaire   +2 more sources

Drug delivery strategies for poorly water-soluble drugs: the industrial perspective

Expert Opinion on Drug Delivery, 2011
For poorly soluble compounds, a good bioavailability is typically needed to assess the therapeutic index and the suitability of the compound for technical development. In industry, the selection of the delivery technology is not only driven by technical targets, but also by constraints, such as production costs, time required for development and the ...
Alfred Fahr
exaly   +3 more sources

Nanocrystallization of Poorly Water Soluble Drugs for Parenteral Administration

Journal of Biomedical Nanotechnology, 2011
Approximately 50% active substances discovered by combinatorial chemistry and high-throughput screening show poor solubility in water. Out of various available approaches "Nanoedege technology" (Combination of Precipitation and Homogenization) was selected. Amphotericin B (Amp B) was used as a model drug.
Foziyah, Zakir, Himanshu, Sharma, Karandeep, Kaur, Basant, Malik, Bhuvaneshwer, Vaidya, Amit K, Goyal, S P, Vyas   +6 more
openaire   +2 more sources