Results 161 to 170 of about 145,891 (201)
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Drug Nanoparticles: Formulating Poorly Water-Soluble Compounds
Toxicologic Pathology, 2008More than 40% of compounds identified through combinatorial screening programs are poorly soluble in water. These molecules are difficult to formulate using conventional approaches and are associated with innumerable formulation-related performance issues.
Elaine M, Merisko-Liversidge +1 more
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Pharmaceutical Methods for Enhancing the Dissolution of Poorly Water-Soluble Drugs
ASSAY and Drug Development Technologies, 2023Low water solubility is the main hindrance in the growth of pharmaceutical industry. Approximately 90% of newer molecules under investigation for drugs and 40% of novel drugs have been reported to have low water solubility. The key and thought-provoking task for the formulation scientists is the development of novel techniques to overcome the ...
Tahir Mahmood +4 more
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Poorly water-soluble drug nanoparticles via solvent evaporation in water-soluble porous polymers
International Journal of Pharmaceutics, 2013A generic method is described to form poorly water-soluble drug nanoparticles within water-soluble porous polymer by solvent evaporation. The simple dissolution of porous polymer with drug nanoparticles results in stable aqueous drug nanoparticle suspension under the optimized conditions.
Aled D Roberts, Haifei Zhang
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Injectable Formulations of Poorly Water-Soluble Drugs
2011A growing number of new therapeutic molecules are limited by low or erratic bioavailability due to poor water solubility. Because of the clinical demand for new and more efficacious anti-cancer, antiviral, and anti-infective drugs, many of these new drugs must be formulated for injection. Poor water solubility can be addressed by a range of formulation
Michael P. Boquet, Dawn R. Wagner
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The use of zein in the controlled release of poorly water-soluble drugs
International Journal of Pharmaceutics, 2019Although zein is a natural protein derived from corn, it has attracted much interest in pharmaceutical and biomedical sciences. Recent remarkable investigations on the use of zein in controlled drug delivery have contributed both important knowledge and potential applications of various products, particularly in the delivery of poorly water-soluble ...
Phuong H L, Tran +3 more
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Injectable Formulations of Poorly Water-Soluble Drugs
2016Each year, an increasing number of new molecular entities are characterized as having poor water solubility. For parenteral formulations, it is exceptionally important that solubility limitations are well understood so that the desired therapeutic activity can be achieved.
Youssef W. Naguib +3 more
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Solubilization of Poorly Water-Soluble Drugs Using Solid Dispersions
Recent Patents on Drug Delivery & Formulation, 2013Many new drugs have been discovered in pharmaceutical industry and exposed their surprised potential therapeutic effects. Unfortunately, these drugs possess low absorption and bioavailability since their solubility limitation in water. Solid dispersion (SD) is the current technique gaining so many attractions from scientists due to its effect on ...
Thao T-D, Tran +4 more
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Novel manufacturing strategies for poorly water-soluble drugs
2022The presented research focuses on innovative additive manufacturing platforms and pharmaceutical formulations to improve the efficacy of the delivered drug. Drug discovery is a time-consuming and expensive process costing approximately US $1.8 billion and involves two major steps namely target identification and lead optimization.
Thakkar, Rishi Chinmay +1 more
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Optimizing the Formulation of Poorly Water-Soluble Drugs
2011With as high as 60 % of drugs in company pipelines exhibiting poor aqueous solubility, the ability to successfully develop a poorly water-soluble drug has become essential. Gaining a detailed understanding of a compound through preformulation studies can be especially challenging for poorly water-soluble drugs limiting their development.
Kevin P. O’Donnell, Robert O. Williams
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Transformation of acidic poorly water soluble drugs into ionic liquids
European Journal of Pharmaceutics and Biopharmaceutics, 2015Poor water solubility of active pharmaceutical ingredients (API) is a major challenge in drug development impairing bioavailability and therapeutic benefit. This study is addressing the possibility to tailor pharmaceutical and physical properties of APIs by transforming these into tetrabutylphosphonium (TBP) salts, including the generation of ionic ...
Anja Balk +5 more
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