Results 181 to 190 of about 50,651 (209)

Development of Amorphous Solid Dispersion to Improve the Dissolution and Antiproliferative Activity of Brazilin. [PDF]

Drug Des Devel Ther
Tristiyanti D, Sriwidodo S, Hamdani S, Daruwati I, Budiman A.   +4 more
europepmc   +1 more source

Bilateral SERS‐Microneedle Patch for Co‐Diagnosis of Diabetes Mellitus and Tuberculosis Comorbidity

Advanced Science, EarlyView.
Our study introduced a U@mP@Au‐mediated bilateral SERS‐microneedle patch for analyzing glucose levels from ISF and sensitively detecting TB biomarkers from sputum, respectively. This integrated dual‐analyte detecting platform can be used for co‐diagnosis of diabetes mellitus (DM) and tuberculosis (TB) comorbidity, which was demonstrated in ex vivo ...
Xueqin Huang, Lingzhi Chen, Jing Xu, Jiaqi Yu, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Lang Rao, Jierong Chen, Junxia Zheng, Haibo Zhou   +12 more
wiley   +1 more source

Unexpected Effect of Digestion Products of Infant Formula in Enhancing the Solubilisation of Tolfenamic Acid During Digestion. [PDF]

Pharmaceutics
Eason T, Salim M, Zann V, Boyd BJ.
europepmc   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

Spray-freeze-drying aprepitant with hydroxypropyl cellulose increases nasal bioavailability. [PDF]

Int J Pharm X
Rautenberg A, Bühlbecker P, Kožák J, Chrétien C, Pellequer Y, Wunderling K, Stoyanov E, Pfeifer A, Lamprecht A.   +8 more
europepmc   +1 more source

Understanding the Catalytic Determinant role of Diaphorase‐Like Subunit in Formate Dehydrogenases via Redox Couples

Advanced Science, EarlyView.
A unique mechanism of catalytic bias regulated by diaphorase‐like subunit in formate dehydrogenase from Rhodobacter aestuarii is revealed. The diaphorase‐like subunit functions act as a biological “voltage rheostat” that controls the slow release of NADH to regulate redox balance, biasing the enzyme's catalytic preference toward CO2 reduction over ...
Kuncheng Zhang, Weisong Liu, Hao Su, Huijuan Cui, Yuanming Wang, Zhiguang Zhu, Chun You, Lingling Zhang   +7 more
wiley   +1 more source

Solvent-free aqueous spray drying of poorly soluble drugs enabled by hot-feed micellar solubilization and high-Tg polymer matrices. [PDF]

Int J Pharm X
Zheng W, Chen H, Xue R, Wu Z, Liu Y, Chen F.   +5 more
europepmc   +1 more source

GC-MS guided phytochemical profiling of Bauhinia tomentosa flowers: molecular docking against HPV-E6 and p53 in cervical cancer. [PDF]

Sci Rep
Trisha S, Balaji R.
europepmc   +1 more source

The Role and Potential of Nanotechnology in Improving Solubility and Enhancing Bioavailability. [PDF]

Pharmaceutics
Hosszú Z, Pártos P, Mahdavi M, Ujhelyi Z, Fehér P, Haimhoffer Á, Bácskay I, Kósa D, Pető Á.   +8 more
europepmc   +1 more source

A Dissolving Microneedle Design for Poorly Water-Soluble Drugs for Enhanced Skin Permeation and Transdermal Delivery Fabricated Using 3D Printing. [PDF]

Micromachines (Basel)
Jin SG.
europepmc   +1 more source