Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug. [PDF]
Asian J Pharm Sci, 2019 Wang X +7 more
europepmc +1 more source
Advanced Science, EarlyView.Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley +1 more source
Impact of Superdisintegrants and Film Thickness on Disintegration Time of Strip Films Loaded With Poorly Water-Soluble Drug Microparticles. [PDF]
J Pharm Sci, 2018 Zhang L +6 more
europepmc +1 more source
Nanocrystal formulation of poorly water-soluble drug
Drug Delivery System, 2015 Kunikazu Moribe, Kenjirou Higashi
openaire +2 more sources
Printable Piezoresistive Hybrid Hydrogels Based on 2D MoS2 for Flexible Pulse Sensing
Advanced Science, EarlyView.Hybrid 1T‐MoS2‐based hydrogels are engineered through UV curing and 3D printing to achieve tunable electromechanical properties for wearable sensing. These soft architectures enhance mechanical stability and reproducible piezoresistive responses within the physiological pressure range.
Jenny Flores +18 more
wiley +1 more source
Application of the combination of ball-milling and hot-melt extrusion in the development of an amorphous solid dispersion of a poorly water-soluble drug with high melting point. [PDF]
RSC Adv, 2019 Fan W, Zhu W, Zhang X, Xu Y, Di L.
europepmc +1 more source
Advanced Science, EarlyView.Upon UV irradiation, flexible and tough hydrogels are formed rapidly (>0.5 s) from dilute (>0.5 wt%) solutions of o‐ethylnitrobenzene–modified PVA. At ∼1.5 wt%, the hydrogels withstand up to 10 MPa compression, remain handleable even after 200‐fold swelling.
Masaaki Okihara +4 more
wiley +1 more source
Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders
Advanced Science, EarlyView.BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley +1 more source
Zero-order release of poorly water-soluble drug from polymeric films made via aqueous slurry casting. [PDF]
Eur J Pharm Sci, 2018 Zhang L, Alfano J, Race D, Davé RN.
europepmc +1 more source
Advanced Science, EarlyView.A deep learning–driven pipeline mining 246 million protein sequences uncovers AhPETase, an evolutionarily distinct PET hydrolase. Engineered variant AhPETaseM1 degrades post‐consumer PET microplastics under physiological conditions and reverses microplasticinduced cytotoxicity in human lung and colon cells, establishing enzymatic microplastic ...
Yuxuan Wang +9 more
wiley +1 more source