Results 171 to 180 of about 145,891 (201)
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Nanoformulation and encapsulation approaches for poorly water-soluble drug nanoparticles
Nanoscale, 2016Various methods used to produce poorly water-soluble drug nanoparticles are reviewed, covering the fundamental, latest progress, and applications.
Ulrike, Wais +3 more
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Novel strategies for the formulation and processing of poorly water-soluble drugs
European Journal of Pharmaceutics and Biopharmaceutics, 2018Low aqueous solubility of active pharmaceutical ingredients presents a serious challenge in the development process of new drug products. This article provides an overview on some of the current approaches for the formulation of poorly water-soluble drugs with a special focus on strategies pursued at the Center of Pharmaceutical Engineering of the TU ...
Katrin, Göke +10 more
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Microcrystals for dissolution rate enhancement of poorly water-soluble drugs
International Journal of Pharmaceutics, 2003Slight dissolution rates related to poor water-solubility are one of the well-known difficulties to be covered during the development of new drug substances. The poorly water-soluble drug ECU-01, a low molecular enzyme-inhibitor with anti-inflammatory properties for oral administration, shows a poor dissolution rate.
Norbert, Rasenack +2 more
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Strategies to Maximize Liposomal Drug Loading for a Poorly Water-soluble Anticancer Drug
Pharmaceutical Research, 2014To develop a liposomal system with high drug loading (DL) for intravenous (i.v.) delivery of a poorly water-soluble basic drug, asulacrine (ASL).A thin-film hydration and extrusion method was used to fabricate the PEGylated liposomal membranes followed by a freeze and thaw process.
Zhang, Wenli +10 more
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Nanoparticles: A personal experience for formulating poorly water soluble drugs
Journal of Controlled Release, 2010This short paper is a personal account of the development of techniques to enhance the bioavailability of a series of poorly soluble drugs by particle size reduction to the nanometer size range. This is a nanotechnological approach which has come of age and has had a practical impact on drug delivery. The drug is in effect the nanosystem.
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Strategies for formulating and delivering poorly water-soluble drugs
Journal of Drug Delivery Science and Technology, 2015Water solubility is a key parameter in drug formulation since it highly influences drug pharmacokinetics and pharmacodynamics. In the past decades, the challenge with poorly water soluble drugs has been growing continuously. As a matter of fact, poorly soluble compounds represent 40% of the top 200 oral drugs marketed in the US, 33% of drugs listed in ...
Rodriguez Aller, Marta Ruth +3 more
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Optimizing the Formulation of Poorly Water-Soluble Drugs
2022Xiangyu Ma +3 more
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