Results 251 to 260 of about 147,210 (303)
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Nanoprecipitation for Poorly Water-Soluble Drugs
Current Drug Metabolism, 2018More than 60% of the active pharmaceutical ingredients, which are classified as Biopharmaceutics Classification System class II. The limited solubility of these drug may lead to low therapeutic effects.Nanoprecipitation presents some advantages because it is a straightforward method with low-cost equipment that is easy to scale up.However, there are ...
Tuong N G, Nguyen +4 more
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Hydrotropic Solubilization of Poorly Water-Soluble Drugs
Journal of Pharmaceutical Sciences, 2010The solubilizing ability of two aromatic hydrotropes, N,N-diethylnicotinamide (DENA) and N,N-dimethylbenzamide (DMBA), was investigated using a set of 13 poorly soluble, structurally diverse drugs. The number of aromatic rings in the solute molecule has a very strong effect on the solubility enhancement produced by either hydrotrope.
Ji Young, Kim +4 more
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Drug Nanoparticles: Formulating Poorly Water-Soluble Compounds
Toxicologic Pathology, 2008More than 40% of compounds identified through combinatorial screening programs are poorly soluble in water. These molecules are difficult to formulate using conventional approaches and are associated with innumerable formulation-related performance issues.
Elaine M, Merisko-Liversidge +1 more
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Nanonization strategies for poorly water-soluble drugs
Drug Discovery Today, 2011Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor(®) EL).
Huabing, Chen +4 more
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Nanocrystallization of Poorly Water Soluble Drugs for Parenteral Administration
Journal of Biomedical Nanotechnology, 2011Approximately 50% active substances discovered by combinatorial chemistry and high-throughput screening show poor solubility in water. Out of various available approaches "Nanoedege technology" (Combination of Precipitation and Homogenization) was selected. Amphotericin B (Amp B) was used as a model drug.
Foziyah, Zakir +6 more
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Solubilization of Poorly Water-Soluble Drugs Using Solid Dispersions
Recent Patents on Drug Delivery & Formulation, 2013Many new drugs have been discovered in pharmaceutical industry and exposed their surprised potential therapeutic effects. Unfortunately, these drugs possess low absorption and bioavailability since their solubility limitation in water. Solid dispersion (SD) is the current technique gaining so many attractions from scientists due to its effect on ...
Thao T-D, Tran +4 more
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Poorly water-soluble drug nanoparticles via solvent evaporation in water-soluble porous polymers
International Journal of Pharmaceutics, 2013A generic method is described to form poorly water-soluble drug nanoparticles within water-soluble porous polymer by solvent evaporation. The simple dissolution of porous polymer with drug nanoparticles results in stable aqueous drug nanoparticle suspension under the optimized conditions.
Aled D, Roberts, Haifei, Zhang
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Injectable Formulations of Poorly Water-Soluble Drugs
2011A growing number of new therapeutic molecules are limited by low or erratic bioavailability due to poor water solubility. Because of the clinical demand for new and more efficacious anti-cancer, antiviral, and anti-infective drugs, many of these new drugs must be formulated for injection. Poor water solubility can be addressed by a range of formulation
Michael P. Boquet, Dawn R. Wagner
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Drug delivery strategies for poorly water-soluble drugs: the industrial perspective
Expert Opinion on Drug Delivery, 2011For poorly soluble compounds, a good bioavailability is typically needed to assess the therapeutic index and the suitability of the compound for technical development. In industry, the selection of the delivery technology is not only driven by technical targets, but also by constraints, such as production costs, time required for development and the ...
Peter, van Hoogevest +2 more
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Injectable Formulations of Poorly Water-Soluble Drugs
2016Each year, an increasing number of new molecular entities are characterized as having poor water solubility. For parenteral formulations, it is exceptionally important that solubility limitations are well understood so that the desired therapeutic activity can be achieved.
Youssef W. Naguib +3 more
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