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Preliminary Study on Different Types of Solid Dispersion Excipients for Improving the Water Solubility and Physical Stability of Celecoxib. [PDF]

Pharmaceutics
Liu B, Rui S, Cai Y, Qian R, Feng S, Liu Z, Zhao Q.   +6 more
europepmc   +1 more source

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Nanoprecipitation for Poorly Water-Soluble Drugs

Current Drug Metabolism, 2018
More than 60% of the active pharmaceutical ingredients, which are classified as Biopharmaceutics Classification System class II. The limited solubility of these drug may lead to low therapeutic effects.Nanoprecipitation presents some advantages because it is a straightforward method with low-cost equipment that is easy to scale up.However, there are ...
Tuong N G, Nguyen, Van-Thanh, Tran, Wei, Duan, Phuong H L, Tran, Thao T D, Tran   +4 more
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Hydrotropic Solubilization of Poorly Water-Soluble Drugs

Journal of Pharmaceutical Sciences, 2010
The solubilizing ability of two aromatic hydrotropes, N,N-diethylnicotinamide (DENA) and N,N-dimethylbenzamide (DMBA), was investigated using a set of 13 poorly soluble, structurally diverse drugs. The number of aromatic rings in the solute molecule has a very strong effect on the solubility enhancement produced by either hydrotrope.
Ji Young, Kim, Sungwon, Kim, Michelle, Papp, Kinam, Park, Rodolfo, Pinal   +4 more
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Drug Nanoparticles: Formulating Poorly Water-Soluble Compounds

Toxicologic Pathology, 2008
More than 40% of compounds identified through combinatorial screening programs are poorly soluble in water. These molecules are difficult to formulate using conventional approaches and are associated with innumerable formulation-related performance issues.
Elaine M, Merisko-Liversidge, Gary G, Liversidge   +1 more
openaire   +2 more sources

Nanonization strategies for poorly water-soluble drugs

Drug Discovery Today, 2011
Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor(®) EL).
Huabing, Chen, Chalermchai, Khemtong, Xiangliang, Yang, Xueling, Chang, Jinming, Gao   +4 more
openaire   +2 more sources

Nanocrystallization of Poorly Water Soluble Drugs for Parenteral Administration

Journal of Biomedical Nanotechnology, 2011
Approximately 50% active substances discovered by combinatorial chemistry and high-throughput screening show poor solubility in water. Out of various available approaches "Nanoedege technology" (Combination of Precipitation and Homogenization) was selected. Amphotericin B (Amp B) was used as a model drug.
Foziyah, Zakir, Himanshu, Sharma, Karandeep, Kaur, Basant, Malik, Bhuvaneshwer, Vaidya, Amit K, Goyal, S P, Vyas   +6 more
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Solubilization of Poorly Water-Soluble Drugs Using Solid Dispersions

Recent Patents on Drug Delivery & Formulation, 2013
Many new drugs have been discovered in pharmaceutical industry and exposed their surprised potential therapeutic effects. Unfortunately, these drugs possess low absorption and bioavailability since their solubility limitation in water. Solid dispersion (SD) is the current technique gaining so many attractions from scientists due to its effect on ...
Thao T-D, Tran, Phuong H-L, Tran, Tran N, Khanh, Toi V, Van, Beom-Jin, Lee   +4 more
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Poorly water-soluble drug nanoparticles via solvent evaporation in water-soluble porous polymers

International Journal of Pharmaceutics, 2013
A generic method is described to form poorly water-soluble drug nanoparticles within water-soluble porous polymer by solvent evaporation. The simple dissolution of porous polymer with drug nanoparticles results in stable aqueous drug nanoparticle suspension under the optimized conditions.
Aled D, Roberts, Haifei, Zhang
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Injectable Formulations of Poorly Water-Soluble Drugs

2011
A growing number of new therapeutic molecules are limited by low or erratic bioavailability due to poor water solubility. Because of the clinical demand for new and more efficacious anti-cancer, antiviral, and anti-infective drugs, many of these new drugs must be formulated for injection. Poor water solubility can be addressed by a range of formulation
Michael P. Boquet, Dawn R. Wagner
openaire   +1 more source