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Drug delivery strategies for poorly water-soluble drugs: the industrial perspective
Expert Opinion on Drug Delivery, 2011For poorly soluble compounds, a good bioavailability is typically needed to assess the therapeutic index and the suitability of the compound for technical development. In industry, the selection of the delivery technology is not only driven by technical targets, but also by constraints, such as production costs, time required for development and the ...
Peter, van Hoogevest +2 more
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Injectable Formulations of Poorly Water-Soluble Drugs
2016Each year, an increasing number of new molecular entities are characterized as having poor water solubility. For parenteral formulations, it is exceptionally important that solubility limitations are well understood so that the desired therapeutic activity can be achieved.
Youssef W. Naguib +3 more
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Solubility Enhancement Techniques for Poorly Water-Soluble Drugs
International Journal of Pharmaceutical Sciences and Nanotechnology, 2017Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for optimum pharmacological response. Poorly water-soluble drugs often require high doses in order to reach therapeutic plasma concentrations ...
Amol S Deshmukh +2 more
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Transformation of acidic poorly water soluble drugs into ionic liquids
European Journal of Pharmaceutics and Biopharmaceutics, 2015Poor water solubility of active pharmaceutical ingredients (API) is a major challenge in drug development impairing bioavailability and therapeutic benefit. This study is addressing the possibility to tailor pharmaceutical and physical properties of APIs by transforming these into tetrabutylphosphonium (TBP) salts, including the generation of ionic ...
Anja Balk +5 more
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Nanoformulation and encapsulation approaches for poorly water-soluble drug nanoparticles
Nanoscale, 2016Various methods used to produce poorly water-soluble drug nanoparticles are reviewed, covering the fundamental, latest progress, and applications.
Ulrike, Wais +3 more
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Improving “gut feelings” for poorly water-soluble drugs
Science Translational Medicine, 2018A nanocarrier system self-assembled in the intestine significantly improves oral availability of poorly water-soluble drugs.
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Microcrystals for dissolution rate enhancement of poorly water-soluble drugs
International Journal of Pharmaceutics, 2003Slight dissolution rates related to poor water-solubility are one of the well-known difficulties to be covered during the development of new drug substances. The poorly water-soluble drug ECU-01, a low molecular enzyme-inhibitor with anti-inflammatory properties for oral administration, shows a poor dissolution rate.
Norbert, Rasenack +2 more
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Redispersible fast dissolving nanocomposite microparticles of poorly water-soluble drugs
International Journal of Pharmaceutics, 2014Enhanced recovery/dissolution of two wet media-milled, poorly water-soluble drugs, Griseofulvin (GF) and Azodicarbonamide (AZD), incorporated into nanocomposite microparticles (NCMPs) via fluidized bed drying (FBD) and spray-drying (SD) was investigated.
Anagha, Bhakay +3 more
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Optimizing the Formulation of Poorly Water-Soluble Drugs
2011With as high as 60 % of drugs in company pipelines exhibiting poor aqueous solubility, the ability to successfully develop a poorly water-soluble drug has become essential. Gaining a detailed understanding of a compound through preformulation studies can be especially challenging for poorly water-soluble drugs limiting their development.
Kevin P. O’Donnell, Robert O. Williams
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Nanoparticles: A personal experience for formulating poorly water soluble drugs
Journal of Controlled Release, 2010This short paper is a personal account of the development of techniques to enhance the bioavailability of a series of poorly soluble drugs by particle size reduction to the nanometer size range. This is a nanotechnological approach which has come of age and has had a practical impact on drug delivery. The drug is in effect the nanosystem.
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