Results 61 to 70 of about 121,997 (290)

Influence of process variables on the properties of simvastatin self-emulsifying granules obtained through high shear wet granulation [PDF]

, 2015
Improvements of the oral bioavailability of lipophilic drugs can be obtained using lipidic formulations such as the self-emulsifying drug delivery systems.
Benda L., FRANCESCHINIS, ERICA, Perssutti B., REALDON, NICOLA, SANTOMASO, ANDREA CLAUDIO, Voinovich D.   +5 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A novel method for quantitative determination of aceclofenac in bulk drug and tablets using sodium salicylate as a hydrotropic solubilizing agent

Journal of Advanced Pharmaceutical Technology & Research, 2010
In titrimetric analysis costlier organic solvents are more often employed to solubilize the poorly water-soluble drugs. Volatility and pollution are drawbacks of such solvents.
R K Maheshwari, Shruti Moondra
doaj   +2 more sources

Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs

Scientifica, 2016
Oral administration is the most convenient route among various routes of drug delivery as it offers high patient compliance. However, the poor aqueous solubility and poor enzymatic/metabolic stability of drugs are major limitations in successful oral ...
Mayank Sharma, Rajesh Sharma, Dinesh Kumar Jain   +2 more
doaj   +1 more source

Crosslinked hydrogels—a promising class of insoluble solid molecular dispersion carriers for enhancing the delivery of poorly soluble drugs

Acta Pharmaceutica Sinica B, 2014
Water-insoluble materials containing amorphous solid dispersions (ASD) are an emerging category of drug carriers which can effectively improve dissolution kinetics and kinetic solubility of poorly soluble drugs.
Dajun D. Sun, Ping I. Lee
doaj   +1 more source

Hydrophilic Matrices for Oral Control Drug Delivery [PDF]

, 2015
Oral controlled drug delivery has gathered tremendous attention over the years due to its many advantages over conventional dosage forms. Polymer-based matrices have become an integral part of the pharmaceutical industry. Hydrophilic matrices are capable
Conway, Barbara R, Ghori, Muhammad U.
core   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Production of nanostructured molecular liquids by supercritical CO2 processing

OpenNano, 2017
Stable molecular clusters of ibuprofen and naproxen were prepared in dry ice, by supersonic jet expansion of their supercritical CO2 drug formulations into a liquid nitrogen cooled collection vessel, with up to 80% yield.
Sudhir Kumar Sharma, Abiy D. Woldetsadik, Thomas Blanton, Matthew J. O'Connor, Mazin Magzoub, Ramesh Jagannathan   +5 more
doaj   +1 more source

Orodispersible Polymer Films with the Poorly Water-Soluble Drug, Olanzapine: Hot-Melt Pneumatic Extrusion for Single-Process 3D Printing

Pharmaceutics, 2020
Amorphous solid dispersions (ASDs) improve the oral delivery of poorly water-soluble drugs. ASDs of olanzapine (OLZ), which have a high melting point and low solubility, are performed using a complicated process.
Hui-Won Cho, Seung-Hoon Baek, Beom-Jin Lee, Hyo-Eon Jin   +3 more
doaj   +1 more source

Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis [PDF]

, 2011
Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites <i>Trypanosoma brucei</i> (<i>T.b.</i>) <i>gambiense</i> or <i>T.b.rhodesiense</i> and is ...
AA Poltera, Amy Jones, B Evrard, B Raz, Barbara Bradley, BJ Berger, C Burri, C Burri, CA Hunter, Christopher McCabe, E Torreele, EW Hurst, FIC Apted, FW Jennings, George Gettinby, H Hirumi, J Opigo, J Pepin, J Pepin, J Rodgers, J Rodgers, Jayne Raper, Jean Rodgers, JH Zar, JLM Atouguia, JW Wong, Michael P. Barrett, MP Barrett, MP Barrett, NJ Abbott, Peter G. E. Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, RL Carrier, S Ben Zirar, S Gibaud, SL Soignet, Stéphane Gibaud, T Loftsson, T Loftsson, V Lejon, VJ Stella   +45 more
core   +7 more sources