Results 51 to 60 of about 104,284 (184)

Measuring and using admixture to study the genetics of complex diseases

Human Genomics, 2003
Admixture is an important evolutionary force that can and should be used in efforts to apply genomic data and technology to the study of complex disease genetics.
Halder Indrani, Shriver Mark D
doaj   +1 more source

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates. [PDF]

, 2020
Current evidence from case/control studies indicates that genetic risk for psychiatric disorders derives primarily from numerous common variants, each with a small phenotypic impact. The literature describing apparent segregation of bipolar disorder (BP)
Aldana, Ileana, Araya, Carmen, Araya, Xinia, Bearden, Carrie E, Bedoya, Gabriel, Bejarano, Julio, Cantor, Rita M, Castrillón, Gabriel, Coppola, Giovanni, Escobar, Javier I, Fears, Scott C, Freimer, Nelson B, Gomez-Makhinson, Juliana, Huang, Alden Y, Hwang, Sun-Goo, Kremeyer, Barbara, Lopez, Maria C, Lopez-Jaramillo, Carlos, Macaya, Gabriel, Molina, Julio, Montoya, Claudia P, Montoya, Gabriel, Mullins, Niamh, Olde Loohuis, Loes M, Ophoff, Roel A, Ori, Anil PS, Ospina-Duque, Jorge, Park, YoungJun, Ramensky, Vasily, Ramirez, Margarita, Reus, Victor, Ruiz-Linares, Andres, Sabatti, Chiara, Service, Susan K, Spesny, Mitzi, Sul, Jae Hoon, Teshiba, Terri M, Zhang, Zhongyang   +37 more
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Habitat Predicts Levels of Genetic Admixture in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2017
Genetic admixture can provide material for populations to adapt to local environments, and this process has played a crucial role in the domestication of plants and animals.
Viranga Tilakaratna, Douda Bensasson
doaj   +1 more source

Inference of population splits and mixtures from genome-wide allele frequency data [PDF]

, 2012
Many aspects of the historical relationships between populations in a species are reflected in genetic data. Inferring these relationships from genetic data, however, remains a challenging task. In this paper, we present a statistical model for inferring
A Keinan, A RoyChoudhury, AL Price, AR Boyko, BM Henn, BM vonHoldt, BS Weir, C Becquet, D Reich, D Reich, D Reich, DH Huson, DJ Lawson, EY Durand, G Bhatia, G Coop, G Hellenthal, G Liti, G McVean, G Nicholson, GM Lathrop, HG Parker, Hua Tang, I Gronau, J Felsenstein, J Felsenstein, J Felsenstein, J Hey, J Novembre, J Novembre, J Novembre, J Sirén, J Sukumaran, JK Pritchard, JK Pritchard, Jonathan K. Pritchard, Joseph K. Pickrell, JZ Li, K Lindblad-Toh, LL Cavalli-Sforza, LL Cavalli-Sforza, LL Cavalli-Sforza, LL Cavalli-Sforza, LS Kubatko, M Bonhomme, M DeGiorgio, M Jakobsson, M Nei, M Nei, M Rasmussen, MA Beaumont, N Patterson, N Patterson, N Saitou, NA Rosenberg, O François, P Beerli, P Menozzi, P Moorjani, R Nielsen, RE Green, RJ Dyer, RL Cann, RN Gutenkunst, RR Hudson, S Xu, SF Schaffner   +66 more
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A Novel and Fast Approach for Population Structure Inference Using Kernel-PCA and Optimization (PSIKO) [PDF]

, 2014
Population structure is a confounding factor in Genome Wide Association Studies, increasing the rate of false positive associations. In order to correct for it, several model-based algorithms such as ADMIXTURE and STRUCTURE have been proposed. These tend
Bancroft, Ian, Harper, Andrea, Huber, Katharina T., Popescu, Andrei-Alin, Trick, Martin   +4 more
core   +2 more sources

A panel of ancestry informative markers for the complex five-way admixed South African coloured population. [PDF]

PLoS ONE, 2013
Admixture is a well known confounder in genetic association studies. If genome-wide data is not available, as would be the case for candidate gene studies, ancestry informative markers (AIMs) are required in order to adjust for admixture. The predominant
Michelle Daya, Lize van der Merwe, Ushma Galal, Marlo Möller, Muneeb Salie, Emile R Chimusa, Joshua M Galanter, Paul D van Helden, Brenna M Henn, Chris R Gignoux, Eileen Hoal   +10 more
doaj   +1 more source

Demographic history and admixture dynamics in African Sahelian populations [PDF]

Human Molecular Genetics, 2020
AbstractThe Sahel/Savannah belt of Africa is a contact zone between two subsistence systems (nomadic pastoralism and sedentary farming) and of two groups of populations, namely Eurasians penetrating from northern Africa southwards and sub-Saharan Africans migrating northwards. Because pastoralism is characterized by a high degree of mobility, it leaves
Viktor Černý, Cesar Fortes-Lima, Petr Tříska   +2 more
openaire   +2 more sources

Inferring the population structure and admixture history of three Hmong-Mien-speaking Miao tribes from southwest China based on genome-wide SNP genotyping

Annals of Human Biology, 2021
Background Hmong-Mien speaking Miao, also called Hmong, is the sixth largest ethnic group in mainland China. However, the fine-scale genetic profiles and population history of Miao populations in southwest China, especially in Guizhou province, remain ...
Ting Luo, Rui Wang, Chuan-Chao Wang
doaj   +1 more source

Leveraging population admixture to characterize the heritability of complex traits. [PDF]

, 2014
Despite recent progress on estimating the heritability explained by genotyped SNPs (h(2)g), a large gap between h(2)g and estimates of total narrow-sense heritability (h(2)) remains.
Assimes, Themistocles L, Berndt, Sonja I, Bhatia, Gaurav, Blot, William J, Chanock, Stephen, Franceschini, Nora, Goodman, Phyllis G, Gusev, Alexander, Haiman, Christopher, He, Jing, Hennis, Anselm JM, Hsing, Ann, Ingles, Sue A, Isaacs, William, Kittles, Rick A, Klein, Eric A, Kooperberg, Charles, Lange, Leslie A, Nemesure, Barbara, Pasaniuc, Bogdan, Patterson, Nick, Pollack, Samuela, Price, Alkes L, Reich, David, Reiner, Alex P, Rybicki, Benjamin A, Sankararaman, Sriram, Stanford, Janet L, Stevens, Victoria L, Stram, Daniel, Strom, Sara S, Tandon, Arti, Tang, Hua, Vilhjálmsson, Bjarni J, Whitsel, Eric A, Wilson, James G, Witte, John S, Xu, Jianfeng, Young, Taylor, Zaitlen, Noah, Zhang, Jianqi   +40 more
core  

Population genomics of the Asian tiger mosquito, Aedes albopictus. Insights into the recent worldwide invasion [PDF]

, 2017
Aedes albopictus, the “Asian tiger mosquito,” is an aggressive biting mosquito native to Asia that has colonized all continents except Antarctica during the last ~30–40 years. The species is of great public health
Aguirre-Obando, Alexander, Armbruster, Baird, Becker, Beebe, Benedict, Birungi, Bonizzoni, Brady, Brown, Chen, Chen, Chouin-Carneiro, Dalla Pozza, Damal, Danecek, Das, Delatte, Denlinger, Eaton, Egizi, Emerson, Excoffier, Flacio, Foll, Frichot, Galtier, Gloria-Soria, Goubert, Gratz, Hawley, Hemingway, Hurst, Ismail, Jackson, Jombart, Kambhampati, Kambhampati, Kamgang, Kamgang, Kasai, Lamballerie, Lambrechts, Langmead, Lewis, Li, Lischer, Liu, Lounibos, Lounibos, Lourenco de Oliveira, Luu, Manni, Manni, Marcombe, Maynard, Medley, Medlock, Minard, Morens, Mori, Mousson, Nazareno, O'Donnell, Patterson, Paupy, Pech-May, Peterson, Porretta, Porretta, Powell, Puckett, Reiter, Smartt, Sprenger, Stamatakis, Tatem, Trucchi, Urbanelli, Urbanski, Willing, Wong, Wray, Wu, Xu, Zhong   +86 more
core   +2 more sources