Results 1 to 10 of about 232,752 (292)
A geographic history of human genetic ancestry. [PDF]
ScienceDescribing the distribution of genetic variation across individuals is a fundamental goal of population genetics. In humans, traditional approaches for describing population genetic variation often rely on discrete genetic ancestry labels, which, despite their utility, can obscure the complex, multifaceted nature of human genetic history.
Grundler MC, Terhorst J, Bradburd GS.
europepmc +6 more sources
Population genetics models of local ancestry [PDF]
Genetics, 2012 Migrations have played an important role in shaping the genetic diversity of human populations. Understanding genomic data thus requires careful modeling of historical gene flow.
Falush, Li, Simon Gravel
core +3 more sources
Genetic ancestry and population structure in the All of Us Research Program cohort [PDF]
Nature CommunicationsWe analyzed participant genomic variant data to characterize population structure and genetic ancestry for the All of Us cohort (n = 297,549). There is substantial population structure in the cohort, with clusters of closely related participants ...
Shivam Sharma +7 more
doaj +2 more sources
Genetic ancestry concordant RNA splicing in prostate cancer involves oncogenic genes and associates with recurrence [PDF]
npj Precision OncologyBlack men suffer disproportionately from prostate cancer (PCa) compared to men of other races and ethnicities. Comparing the molecular landscape of PCa among Black and White patients has the potential to identify targets for development of new precision ...
Muthana Al Abo +23 more
doaj +2 more sources
Anatolian genetic ancestry in North Lebanese populations. [PDF]
Sci RepAbstract Lebanon’s rich history as a cultural crossroad spanning millennia has significantly impacted the genetic composition of its population through successive waves of migration and conquests from surrounding regions. Within modern-day Lebanon, the Koura district stands out with its unique cultural foundations, primarily characterized by a notably ...
Platt DE +3 more
europepmc +4 more sources
Hispanic/Latino ethnic background and genetic ancestry in relation to atherosclerotic cardiovascular disease risk estimation: Findings from the Multi-Ethnic Study of Atherosclerosis (MESA) [PDF]
American Journal of Preventive CardiologyBackground: Hispanics/Latinos are a heterogenous population with no validated atherosclerotic cardiovascular disease (ASCVD) risk estimation tool. We examined performance of the pooled cohort equation (PCE) across Hispanic/Latino background groups and ...
Bede N. Nriagu +10 more
doaj +2 more sources
Communications Biology, 2022 Here we report three epigenome-wide association studies (EWAS) of DNA methylation on self-reported race, global genetic ancestry, and local genetic ancestry in admixed Americans from three sets of samples, including internal and external replications (N ...
Boyang Li +6 more
doaj +1 more source
Ancestry: How researchers use it and what they mean by it
Frontiers in Genetics, 2023 Background: Ancestry is often viewed as a more objective and less objectionable population descriptor than race or ethnicity. Perhaps reflecting this, usage of the term “ancestry” is rapidly growing in genetics research, with ancestry groups referenced ...
Bege Dauda +15 more
doaj +1 more source
A method for an unbiased estimate of cross-ancestry genetic correlation using individual-level data
Nature Communications, 2023 Cross-ancestry genetic correlation can reveal differences in the genetic basis of traits between populations, but methods can be biased by ancestry-specific genetic architecture. Here, the authors present a method to for estimating cross-ancestry genetic
Md. Moksedul Momin +5 more
doaj +1 more source
Mapping Human Genetic Ancestry [PDF]
Molecular Biology and Evolution, 2007 The human genome is a mosaic with respect to its evolutionary history. Based on a phylogenetic analysis of 23,210 DNA sequence alignments from human, chimpanzee, gorilla, orangutan, and rhesus, we present a map of human genetic ancestry. For about 23% of our genome, we share no immediate genetic ancestry with our closest living relative, the chimpanzee.
Ingo, Ebersberger +5 more
openaire +2 more sources