Results 11 to 20 of about 232,752 (292)

Genetic Ancestry in Lung-Function Predictions [PDF]

New England Journal of Medicine, 2010
Self-identified race or ethnic group is used to determine normal reference standards in the prediction of pulmonary function. We conducted a study to determine whether the genetically determined percentage of African ancestry is associated with lung function and whether its use could improve predictions of lung function among persons who identified ...
Rajesh, Kumar, Max A, Seibold, Melinda C, Aldrich, L Keoki, Williams, Alex P, Reiner, Laura, Colangelo, Joshua, Galanter, Christopher, Gignoux, Donglei, Hu, Saunak, Sen, Shweta, Choudhry, Edward L, Peterson, Jose, Rodriguez-Santana, William, Rodriguez-Cintron, Michael A, Nalls, Tennille S, Leak, Ellen, O'Meara, Bernd, Meibohm, Stephen B, Kritchevsky, Rongling, Li, Tamara B, Harris, Deborah A, Nickerson, Myriam, Fornage, Paul, Enright, Elad, Ziv, Lewis J, Smith, Kiang, Liu, Esteban González, Burchard   +27 more
openaire   +4 more sources

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. [PDF]

Nature Genetics, 2014
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and ...
Abecasis, Goncalo R, Adair, Linda S, Almgren, Peter, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, Atalay, Mustafa, Aung, Tin, Baldassarre, Damiano, Balkau, Beverley, Bao, Yuqian, Barnett, Anthony H, Barroso, Ines, Basit, Abdul, Been, Latonya F, Beilby, John, Bell, Graeme I, Below, Jennifer E, Benediktsson, Rafn, Bergman, Richard N, Boehm, Bernhard O, Boerwinkle, Eric, Bonnycastle, Lori L, Burtt, Noël, Cai, Qiuyin, Campbell, Harry, Carey, Jason, Cauchi, Stephane, Caulfield, Mark, Chan, Juliana CN, Chang, Li-Ching, Chang, Tien-Jyun, Chang, Yi-Cheng, Charpentier, Guillaume, Chen, Chien-Hsiun, Chen, Han, Chen, Yuan-Tsong, Chia, Kee-Seng, Chidambaram, Manickam, Chines, Peter S, Cho, Nam H, Cho, Young Min, Chuang, Lee-Ming, Chuang, Lee-Ming, Collins, Francis S, Cornelis, Marylin C, Couper, David J, Crenshaw, Andrew T, Danesh, John, Das, Debashish, de Faire, Ulf, Dedoussis, George, Deloukas, Panos, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Dimas, Antigone S, Dina, Christian, Doney, Alex S, Donnelly, Peter J, Dorkhan, Mozhgan, Dupuis, Josée, Edkins, Sarah, Elliott, Paul, Emilsson, Valur, Erbel, Raimund, Eriksson, Johan G, Escobedo, Jorge, Esko, Tonu, Eury, Elodie, Ferreira, Teresa, Florez, Jose C, Fontanillas, Pierre, Forouhi, Nita G, Forsen, Tom, Fox, Caroline, Fraser, Ross M, Frayling, Timothy M, Froguel, Philippe, Frossard, Philippe, Gao, Yutang, Gaulton, Kyle J, Gertow, Karl, Gieger, Christian, Gigante, Bruna, Go, Min Jin, Grallert, Harald, Grant, George B, Groves, Chrisropher J, Grrop, Leif C, Horikoshi, Momoko, Johnson, Andrew D, Mahajan, Anubha, Mexican American Type 2 Diabetes (MAT2D) Consortium, Ng, Maggie CY, Prokopenko, Inga, Saleheen, Danish, South Asian Type 2 Diabetes (SAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in muylti-Ethnic Samples (T2D-GENES) Consortium, van Dam, Rob M, van Duijn, Cornelia, Wang, Xu, Zeggini, Eleftheria, Zhang, Weihua   +99 more
core   +2 more sources

Race, Ethnicity and Ancestry in Unrelated Transplant Matching for the National Marrow Donor Program: A Comparison of Multiple Forms of Self-Identification with Genetics. [PDF]

PLoS ONE, 2015
We conducted a nationwide study comparing self-identification to genetic ancestry classifications in a large cohort (n = 1752) from the National Marrow Donor Program.
Jill A Hollenbach, Aliya Saperstein, Mark Albrecht, Cynthia Vierra-Green, Peter Parham, Paul J Norman, Martin Maiers   +6 more
doaj   +1 more source

Genomic supremacy: the harm of conflating genetic ancestry and race

Human Genomics, 2022
Background Recent studies have reignited the tinderbox of debate surrounding the use of race and ancestry in medicine. These controversial studies have argued for a strong correlation between genetic ancestry and race, justifying continued use of genetic
Jessica P. Cerdeña, Vanessa Grubbs, Amy L. Non   +2 more
doaj   +1 more source

Identity and genetic ancestry tracing [PDF]

BMJ, 2002
Tracing genetic identity can lead to resolution of uncertainty but can cause more problems than it solves. Will establishment of genetic identity be cohesive or divisive? What can our genes tell us about who we are? The answer to that question depends on exactly what you want to know.
Carl, Elliott, Paul, Brodwin
openaire   +2 more sources

Guidelines for genetic ancestry inference created through roundtable discussions

HGG Advances, 2023
Summary: The use of genetic and genomic technology to infer ancestry is commonplace in a variety of contexts, particularly in biomedical research and for direct-to-consumer genetic testing.
Jennifer K. Wagner, Joon-Ho Yu, Duana Fullwiley, CeCe Moore, James F. Wilson, Michael J. Bamshad, Charmaine D. Royal   +6 more
doaj   +1 more source

Genetic ancestry of participants in the National Children's Study. [PDF]

, 2014
BackgroundThe National Children's Study (NCS) is a prospective epidemiological study in the USA tasked with identifying a nationally representative sample of 100,000 children, and following them from their gestation until they are 21 years of age.
Arias, Angelo D, Chambers, Christina D, Frazer, Kelly A, Jepsen, Kristen, Shepard, Peter J, Smith, Erin N   +5 more
core   +2 more sources

Co-constructing ancestry through direct-to-consumer genetic testing

TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, 2021
Direct-to-consumer (DTC) genetic ancestry tests offered via the internet supposedly uncover the ancestry of those tested. While these tests might be seen as a means to find a biologically inscribed and fixed genealogy, this paper explores how companies ...
Alexander Lang, Florian Winkler
doaj   +1 more source

The geography of recent genetic ancestry across Europe [PDF]

, 2013
The recent genealogical history of human populations is a complex mosaic formed by individual migration, large-scale population movements, and other demographic events.
A Albrechtsen, A Auton, A Gillett, A Gusev, A Keller, A Zeileis, AE Hoerl, AL Price, AL Price, AM Stuart, B Winney, BL Browning, BM Henn, BM Henn, C Tyler-Smith, CD Huff, Chris Tyler-Smith, CL Epstein, CT O'Dushlaine, DJ Lawson, DLT Rohde, E Jakkula, F Rousset, G McVean, Graham Coop, H Li, J Chang, J Novembre, J Novembre, J Novembre, JA Tennessen, JE Pool, JE Powell, JFC Kingman, JK Gusev, Lowe, JN Fenner, K Harris, KA Frazer, KP Donnelly, M Slatkin, MD Brown, MR Nelson, MR Nelson, N Patterson, N Patterson, N Takahata, NH Chapman, O Lao, P Menozzi, P Moorjani, P Skoglund, P Soares, Peter Ralph, PF Palamara, R Hudson, RA Fisher, RL Cann, S Carmi, S Giglio, S Gravel, S Purcell, Y Petrov   +61 more
core   +4 more sources

CoAIMs: a cost-effective panel of ancestry informative markers for determining continental origins. [PDF]

PLoS ONE, 2010
Genetic ancestry is known to impact outcomes of genotype-phenotype studies that are designed to identify risk for common diseases in human populations.
Eric R Londin, Margaret A Keller, Cathleen Maista, Gretchen Smith, Laura A Mamounas, Ran Zhang, Steven J Madore, Katrina Gwinn, Roderick A Corriveau   +8 more
doaj   +1 more source