Results 111 to 120 of about 5,282,511 (279)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Star Formation History and Chemical Evolution of the Sextans Dwarf Spheroidal Galaxy

open access: yes, 2009
We present the star formation history and chemical evolution of the Sextans dSph dwarf galaxy as a function of galactocentric distance. We derive these from the $VI$ photometry of stars in the $42' \times 28'$ field using the SMART model developed by Yuk
Carrea   +27 more
core   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Western Medicine in a Community in Ghana: A Social Change Review

open access: yesSocial Change Review, 2019
This study focuses on Western medical practices in the Atiwa District of Ghana. The people of Atiwa District accessed Western medicinal practice to prevent and cure diseases.
Adu-Gyamfi Samuel   +4 more
doaj   +1 more source

An electronic family health history tool to identify and manage patients at increased risk for colorectal cancer: protocol for a randomized controlled trial. [PDF]

open access: yes, 2019
BackgroundColorectal cancer is the fourth most commonly diagnosed cancer in the United States. Approximately 3-10% of the population has an increased risk for colorectal cancer due to family history and warrants more frequent or intensive screening. Yet,
Coffman, Cynthia J   +15 more
core  

Neptune's wild days: constraints from the eccentricity distribution of the classical Kuiper Belt

open access: yes, 2012
Neptune's dynamical history shaped the current orbits of Kuiper belt objects (KBOs), leaving clues to the planet's orbital evolution. In the "classical" region, a population of dynamically "hot" high-inclination KBOs overlies a flat "cold" population ...
Dawson, Rebekah I., Murray-Clay, Ruth
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Senescence can play an essential role in modelling and estimation of vector based epidemiological indicators: demographical approach [PDF]

open access: yes
In the paper basic epidemiological indicators, produced by an aging population of vectors, are calculated. In the study we follow two lines: calculations for demographically structured population and individual life-history approach.
Anatoli I. Michalski   +5 more
core  

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