The Material and Immaterial Urban Remains of a Railway Heritage – the case of Araraquara/SP (Brazil) [PDF]
, 2017 The Araraquara Railway Station was built in 1885 as a symbol of prosperity. With the passing time it turned to be something indifferent to the city population, being deactivated in 2015.
Lourencetti, Fernanda de Lima
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Booms, Busts, and Echoes: How the biggest demographic upheaval in history is affecting global development [PDF]
For much (and perhaps most) of human history, demographic patterns were fairly stable: the human population grew slowly, and age structures, birth rates, and death rates changed very little.
David Canning, David E. Bloom
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Reconstructing the population history of the Sinhalese, the major ethnic group in Śrī Laṅkā. [PDF]
iScience, 2023 Singh PP +8 more
europepmc +1 more source
The population history of Germany: research strategy and preliminary results [PDF]
The paper presents the project of an aggregative reconstruction of the population of Ger-many from the sixteenth century to 1840, when official statistics began to provide complete coverage of all German states.
Georg Fertig, Ulrich Pfister
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
[Review of] Russell Thornton. American Indian Holocaust and Survival: A Population History Since 1492 [PDF]
, 1989 A sociologist, Thornton has written a thorough and balanced demographic account of Native American societies in what became the United States from before the arrival of Europeans to the ...
Rusco, Elmer R.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source