Results 131 to 140 of about 5,282,511 (279)

Decision-making for termination of pregnancy following non-invasive prenatal testing: a qualitative exploration of french, english and German healthcare professionals’ perceptions and concerns

Reproductive Health
Non-invasive prenatal testing (NIPT) is offered in the French, English and German public healthcare systems for fetal aneuploidy screening from a relatively early stage of pregnancy (around 10–12 weeks of gestation).
Adeline Perrot, Hilary Bowman-Smart, Tamar Nov-Klaiman, Ruth Horn   +3 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

On the limits of fitting complex models of population history to f-statistics. [PDF]

Elife, 2023
Maier R, Flegontov P, Flegontova O, Işıldak U, Changmai P, Reich D.   +5 more
europepmc   +1 more source

Population Growth Through History and the Escape from the Malthusian Trap [PDF]

, 1985
Artzrouni, Marc, Komlos, John
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Population History Shapes Responses to Different Temperature Regimes in Drosophila subobscura. [PDF]

Life (Basel), 2023
Erić K, Veselinović MS, Patenković A, Davidović S, Erić P, Stamenković-Radak M, Tanasković M.   +6 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Genomic Insights into the Population History of the Resande or Swedish Travelers. [PDF]

Genome Biol Evol, 2023
Vilà-Valls L, Aizpurua-Iraola J, Casinge S, Bojs K, Flores-Bello A, Font-Porterias N, Comas D.   +6 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Population history modulates the fitness effects of Copy Number Variation in the Roma. [PDF]

Hum Genet, 2023
Antinucci M, Comas D, Calafell F.
europepmc   +1 more source