Results 181 to 190 of about 5,282,511 (279)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Population history, genetic variation, and conservation status of European white elm (Ulmus laevis Pall.) in Poland. [PDF]

Ann For Sci, 2022
Litkowiec M, Chudzińska M, Pasławska A, Pałucka M, Kozioł C, Lewandowski A.   +5 more
europepmc   +1 more source

POPULATION GENETICS HISTORY: A PERSONAL VIEW [PDF]

Annual Review of Genetics, 1987
openaire   +2 more sources

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Estimating the Distribution of Fitness Effects in Aye-Ayes (Daubentonia madagascariensis), Accounting for Population History as Well as Mutation and Recombination Rate Heterogeneity. [PDF]

Am J Primatol
Soni V, Versoza CJ, Pfeifer SP, Jensen JD.   +3 more
europepmc   +1 more source

Human impact on the recent population history of the elusive European wildcat inferred from whole genome data. [PDF]

BMC Genomics, 2022
Nieto-Blázquez ME, Schreiber D, Mueller SA, Koch K, Nowak C, Pfenninger M.   +5 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The ecological niche and population history shape mosquito population genetics on a group of three Caribbean islands. [PDF]

Parasit Vectors
Helleman P, Schrama M, Trimbos KB, Braks MAH, Schaffner F, Stroo A, Wouters RM, van der Beek JG.   +7 more
europepmc   +1 more source

Population history and genome wide association studies of birth weight in a native high altitude Ladakhi population. [PDF]

PLoS One, 2022
Bhandari S, Dolma P, Mukerji M, Prasher B, Montgomery H, Kular D, Jain V, Dadhwal V, Williams DJ, Bhattacharyaa A, Gilbert E, Cavalleri GL, Hillman SL.   +12 more
europepmc   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source