Results 131 to 140 of about 300,825 (275)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Eridanus III and DELVE 1: Carbon-rich Primordial Star Clusters or the Smallest Dwarf Galaxies?
The Astrophysical JournalWe present spectroscopy of the ultra-faint Milky Way satellites Eridanus III (Eri III) and DELVE 1. We identify eight member stars in each satellite and place nonconstraining upper limits on their velocity and metallicity dispersions.
Joshua D. Simon +10 more
doaj +1 more source
, 2010 Gamma-Ray Bursts (GRBs) are the most violent explosions in the Universe. Long duration GRBs are associated with the collapse of massive stars, rivaling their host galaxies in luminosity.
Campana, S. +4 more
core +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Spectacular Nucleosynthesis from Early Massive Stars
The Astrophysical Journal LettersStars that formed with an initial mass of over 50 M _⊙ are very rare today, but they are thought to be more common in the early Universe. The fates of those early, metal-poor, massive stars are highly uncertain.
Alexander P. Ji +41 more
doaj +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Hidden Population III Descendants in Ultrafaint Dwarf Galaxies
The Astrophysical JournalThe elusive properties of the first (Population III or Pop III) stars can be indirectly unveiled by uncovering their true descendants. To this end, we exploit our data-calibrated model for the best-studied ultrafaint dwarf galaxy (UFD), Boötes I, which ...
Martina Rossi +4 more
doaj +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Origin of α-poor Very Metal-poor Stars
The Astrophysical JournalAmong very metal-poor (VMP) stars, α -poor VMP ( α -PVMP) stars that have subsolar values of [X/Fe] for Mg and other α elements are rare and are thought to have been formed from gas polluted by Type 1a supernova (SN 1a). However, recent analyses indicate
S. K. Jeena, Projjwal Banerjee
doaj +1 more source
Eruptive mass loss in very massive stars and Population III stars [PDF]
, 2009 12 pages, 4 figs. To appear in proceedings of STScI May Symposium 2006, "Massive Stars: From Pop III and GRBs to the Milky Way".
openaire +2 more sources