Results 101 to 110 of about 12,172,512 (307)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Estimating regional trajectories and trends of seabirds from sparse and inconsistent colony counts: case studies from eastern Canada with Leach’s Storm-Petrel and Atlantic Puffin

Avian Conservation and Ecology
Regional seabird population monitoring is often characterized by sparse and imprecise counts from a large number of colonies, which can vary in abundance by several orders of magnitude and may show complex and concordant trajectories over time.
David T. Iles, Sarah E Gutowsky, Anna M Calvert, Sabina I Wilhelm, Jean-François Rail, April Hedd, Heather L Major, Adam C Smith, Gregory J. Robertson   +8 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

An approach for using off-the-shelf object-based image analysis software to detect and count birds in large volumes of aerial imagery

Avian Conservation and Ecology, 2018
Computer-automated image analysis techniques can save time and resources for detecting and counting birds in aerial imagery. Sophisticated object-based image analysis (OBIA) software is now widely available and has proven effective for various ...
Dominique Chabot, Christopher Dillon, Charles M. Francis   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Camera Traps: A Novel Method to Estimate Numbers of Nesting Sea Turtles

Ecology and Evolution
Abundance estimates are difficult to obtain for many animal groups, yet essential for endangered species management and conservation. For sea turtles, estimates are made from ground counts of nesting females, tracks, and nests, but these are challenging ...
Holly J. Stokes, Graeme C. Hays, Kimberley L. Stokes, Nicole Esteban   +3 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Assessing Applicability of eDNA‐Based Sampling for Population Monitoring of Leatherback Turtles in the Northeast Indian Ocean

Environmental DNA
Current population genetics studies of sea turtles primarily rely on invasive tissue sampling or blood draws, which involve the capture and handling of the animals that require specific permits and resources.
Maslim As‐singkily, Reindert Nijland, Iliana Bista, Peter H. Dutton, Leontine E. Becking   +4 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

No evidence of migration in a 4-year study of an at-risk migratory fish—the centenarian bigmouth buffalo (Ictiobus cyprinellus) of Saskatchewan

FACETS
The bigmouth buffalo (Ictiobus cyprinellus, Valenciennes 1844) is a long-lived freshwater fish native to North America that is listed as a species of special concern in its Saskatchewan-Nelson range.
Reid N. Bryshun, Gabrielle H. Achtymichuk, Maud C.O. Ferrari   +2 more
doaj   +1 more source