Results 101 to 110 of about 8,501,303 (306)

Mutagénesis ambiental y el uso de biomarcadores para predecir el riesgo de cáncer

Revista de Biología Tropical, 2004
La mutagénesis ambiental o genética toxicológica es una disciplina que tiene como objetivo estudiar el daño genético que conduce a mutaciones, producido por agentes físicos, químicos y biológicos, identificar estos agentes, analizar sus interacciones y ...
Patricia Cuenca, Vanessa Ramírez
doaj  

Genetic monitoring of Proteus populations

Natura Sloveniae, 2016
n ...
Peter Trontelj, Valerija Zakšek
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Neoclassical growth models and the optimum rate of population growth (with applications to underdeveloped countries) [PDF]

, 1970
For more about the East-West Center, see http://www.eastwestcenter.org/Among economists who are also interested in demography, there is a respectable tradition of analysis revolving around the concept of a static optimum population. The work of W.
Crouch, Robert L., East-West Population Institute   +1 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Components of regional population growth, 1986-2001 [PDF]

, 2004
The vitality of a region is frequently assessed by looking at its population growth pattern. This is seen as being linked to its economic and social vibrancy.
Pool, Ian, Baxendine, Sandra, Cochrane, William   +2 more
core  

Silent survivors: how monitoring and genetics reveal the recovery of the Adriatic sturgeon

The European Zoological Journal
The Adriatic sturgeon (Acipenser naccarii) is a critically endangered species that has been the focus of conservation efforts for the past three decades.
C. Samassa, G. Castaldelli, L. Congiu, E. Boscari   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Estimating regional trajectories and trends of seabirds from sparse and inconsistent colony counts: case studies from eastern Canada with Leach’s Storm-Petrel and Atlantic Puffin

Avian Conservation and Ecology
Regional seabird population monitoring is often characterized by sparse and imprecise counts from a large number of colonies, which can vary in abundance by several orders of magnitude and may show complex and concordant trajectories over time.
David T. Iles, Sarah E Gutowsky, Anna M Calvert, Sabina I Wilhelm, Jean-François Rail, April Hedd, Heather L Major, Adam C Smith, Gregory J. Robertson   +8 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source