Results 101 to 110 of about 3,181,850 (358)

Live Long, Live Well: Quantifying the Health of Heterogenous Populations [PDF]

Various health-, quality-, and disability-adjusted life year or life expectancy (HALY, QALY, DALY; HALE, QALE, DALE) measures have become gold standards for defining outcomes in technology evaluation, population health monitoring, and other evaluative ...
John Mullahy
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Camera Traps: A Novel Method to Estimate Numbers of Nesting Sea Turtles

Ecology and Evolution
Abundance estimates are difficult to obtain for many animal groups, yet essential for endangered species management and conservation. For sea turtles, estimates are made from ground counts of nesting females, tracks, and nests, but these are challenging ...
Holly J. Stokes, Graeme C. Hays, Kimberley L. Stokes, Nicole Esteban   +3 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Assessing Applicability of eDNA‐Based Sampling for Population Monitoring of Leatherback Turtles in the Northeast Indian Ocean

Environmental DNA
Current population genetics studies of sea turtles primarily rely on invasive tissue sampling or blood draws, which involve the capture and handling of the animals that require specific permits and resources.
Maslim As‐singkily, Reindert Nijland, Iliana Bista, Peter H. Dutton, Leontine E. Becking   +4 more
doaj   +1 more source

No evidence of migration in a 4-year study of an at-risk migratory fish—the centenarian bigmouth buffalo (Ictiobus cyprinellus) of Saskatchewan

FACETS
The bigmouth buffalo (Ictiobus cyprinellus, Valenciennes 1844) is a long-lived freshwater fish native to North America that is listed as a species of special concern in its Saskatchewan-Nelson range.
Reid N. Bryshun, Gabrielle H. Achtymichuk, Maud C.O. Ferrari   +2 more
doaj   +1 more source

Population monitoring of trisomy 21: problems and approaches. [PDF]

Mol Cytogenet, 2023
Sperling K, Scherb H, Neitzel H.
europepmc   +1 more source

Assessment of the susceptibility status of Aedes aegypti (Diptera: Culicidae) populations to pyriproxyfen and malathion in a national wide monitoring of insecticide resistance in Brazil, 2017-2018. [PDF]

, 2020
Kauara Brito Campos, Ademir Jesus Martins, Cynara de Melo Rodovalho, Diogo Fernandes Bellinato, Luciana dos Santos Dias, Maria de Lourdes da Graça Macoris, Maria Teresa Macoris Andrighetti, José Bento Pereira Lima, Marcos Takashi Obara   +8 more
openalex   +1 more source

An AIHW framework for assessing data sources for population health monitoring: working paper [PDF]

This paper outlines the Australian Institute of Health and Welfare\u27s (AIHW) assessment framework for determining the suitability of specific data sources for population health monitoring.

core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source