Population Pharmacokinetics of Asundexian in People at Risk for Thromboembolic/Cardiovascular Events. [PDF]
Yassen A +7 more
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Population Pharmacokinetics and Exposure-Response Analyses for Telisotuzumab Vedotin in Patients With c-Met Protein Overexpressing Tumors. [PDF]
Babel H +7 more
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Population Pharmacokinetics and Model-Informed Dose Optimization of Teicoplanin in Adults with Hematological Malignancies. [PDF]
García-Hervalejo M +4 more
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Population pharmacokinetics/pharmacodynamics and safety of YPEG-rhGH in elderly subjects. [PDF]
He Y +8 more
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Population pharmacokinetics of tenofovir alafenamide delivered via an annual subdermal implant in South African women. [PDF]
Beliveau M +9 more
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Population pharmacokinetics of fosmidomycin and clindamycin in combination with artesunate for uncomplicated Plasmodium falciparum malaria in Gabonese children and adults. [PDF]
Pfaffendorf C +8 more
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Population Pharmacokinetics of Lamotrigine
Therapeutic Drug Monitoring, 2001The present study estimated the population pharmacokinetics of lamotrigine in patients receiving oral lamotrigine therapy with drug concentration monitoring, and determined intersubject and intrasubject variability. A total of 129 patients were analyzed from two clinical sites. Of these, 124 patients provided sparse data (198 concentration-time points);
Chan, V., Morris, R., Ilet, K., Tett, S.
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The application of population approaches to drug development is recommended in several US Food and Drug Administration (FDA) guidance documents. Population pharmacokinetic (and pharmacodynamic) techniques enable identification of the sources of inter- and intra-individual variability that impinge upon drug safety and efficacy.
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Population pharmacokinetics of oxaliplatin
Cancer Chemotherapy and Pharmacology, 2002The objective of this study was to explore correlations between a variety of covariates and oxaliplatin ultrafilterable and blood pharmacokinetic parameters. Data from 40 patients receiving oxaliplatin combined with 5-fluorouracil and levofolinic acid as standard treatment for advanced colorectal cancer were analysed. Plasma ultrafilterable, blood, and
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