Results 121 to 130 of about 114,024 (159)
Some of the next articles are maybe not open access.
Nonparametric Methods in Population Pharmacokinetics
The Journal of Clinical Pharmacology, 2020AbstractPopulation pharmacokinetic (PK) modeling is a widely used approach to analyze PK data obtained from groups of individuals, in both industry and academic research. The approach can also be used to analyze pharmacodynamic (PD) data and pooled PK/PD data. There are 2 main families of population PK methods: parametric and nonparametric.
Goutelle, Sylvain +5 more
openaire +3 more sources
Population Pharmacokinetics and Pharmacokinetic-Pharmacodynamic Relationships for Docetaxel
Investigational New Drugs, 2001The population approach has been implemented prospectively in the clinical development of docetaxel (Taxotere). Overall 640 patients were evaluable for the population PK/PD analysis. The PK analysis evidenced significant covariates explaining the inter-patient variability of docetaxel clearance and the PK/PD analysis demonstrated that the variability ...
R, Bruno +4 more
openaire +2 more sources
Annals of Pharmacotherapy, 2004
OBJECTIVE To present a framework within which population pharmacokinetic (PPK) studies should be designed and analyzed and discuss the application of developed PPK models. METHODS Information on PPK was retrieved from a MEDLINE search (
Ene I, Ette +2 more
openaire +2 more sources
OBJECTIVE To present a framework within which population pharmacokinetic (PPK) studies should be designed and analyzed and discuss the application of developed PPK models. METHODS Information on PPK was retrieved from a MEDLINE search (
Ene I, Ette +2 more
openaire +2 more sources
Population Pharmacokinetic Analysis of Bisoprolol
Clinical Pharmacokinetics, 1989The technique of population pharmacokinetic analysis was employed to study the variability in the dose concentration relationship of bisoprolol during its clinical development. The influence of demographic factors on the variability of clearance was investigated in 3 different populations: group I, patients (including an elderly group) with essential ...
J, Grevel, P, Thomas, B, Whiting
openaire +2 more sources
Population Pharmacokinetics/Dynamics*
Annual Review of Pharmacology and Toxicology, 1992L B, Sheiner, T M, Ludden
openaire +2 more sources
Population pharmacokinetics of etoposide*
Int. Journal of Clinical Pharmacology and Therapeutics, 2002S, Reif +6 more
openaire +2 more sources
Population pharmacokinetics of sirolimus
Clinical Pharmacology & Therapeutics, 1998G M, Ferron +3 more
openaire +2 more sources
Abstract The role of population pharmacokinetics in drug development is introduced.
Phil Ambery +2 more
openaire +1 more source
Phil Ambery +2 more
openaire +1 more source
International journal of clinical pharmacology, therapy, and toxicology, 1993
Traditionally pharmacokinetic studies have been performed in small homogenous groups of subjects, often normal healthy, young male volunteers. These studies are well controlled and generate meaningful baseline data. However, concern has been expressed that insufficient data is collected at an early state in the target population during a drug's ...
openaire +1 more source
Traditionally pharmacokinetic studies have been performed in small homogenous groups of subjects, often normal healthy, young male volunteers. These studies are well controlled and generate meaningful baseline data. However, concern has been expressed that insufficient data is collected at an early state in the target population during a drug's ...
openaire +1 more source