Results 111 to 120 of about 114,024 (159)
Some of the next articles are maybe not open access.
Pharmacokinetics in special populations
Drug Metabolism Reviews, 2009Pharmacokinetics are typically dependent on a variety of physiological variables (e.g., age, ethnicity, or pregnancy) or pathological conditions (e.g., renal and hepatic insufficiency, cardiac dysfunction, obesity, etc.). The influence of some of these conditions has not always been thoroughly assessed in the clinical studies of antiallergic drugs ...
Italo, Poggesi +5 more
openaire +2 more sources
Population pharmacokinetics of ramosetron
Journal of Pharmacokinetics and Pharmacodynamics, 2015Ramosetron is a selective serotonergic 5-hydroxy-tryptamine receptor 3 antagonist that is used to prevent and treat postoperative nausea and vomiting. This study aimed to characterize the population pharmacokinetics of ramosetron in patients undergoing surgery with general anesthesia.
Seong Heon Lee +3 more
openaire +2 more sources
The Journal of Clinical Pharmacology, 1988
The major strength of the population analysis approach is that useful information can be extracted from sparse data using blood samples and pharmacologic monitoring during routine safety and efficacy studies conducted during the development of a drug product.
openaire +2 more sources
The major strength of the population analysis approach is that useful information can be extracted from sparse data using blood samples and pharmacologic monitoring during routine safety and efficacy studies conducted during the development of a drug product.
openaire +2 more sources
Population Pharmacokinetics of Terfenadine
Pharmaceutical Research, 1996After oral administration of terfenadine, plasma concentrations of the parent drug are usually below the limits of quantitation of conventional analytical methods because of extensive first-pass metabolism. Data are usually reported on the carboxylic acid metabolite (M1) but there are no published reports of pharmacokinetic parameters for terfenadine ...
R L, Lalonde, D, Lessard, J, Gaudreault
openaire +2 more sources
Population Pharmacokinetics of Desvenlafaxine: Pharmacokinetics in Korean Versus US Populations
Clinical Pharmacology in Drug Development, 2017AbstractDesvenlafaxine exposure in Korean and US populations was compared using population pharmacokinetic (PK) analysis. Data from a single‐ and multiple‐dose study of desvenlafaxine (50, 100, and 200 mg) in 30 healthy Korean subjects were added to a population PK model previously developed using sparse PK samples from patients with major depressive ...
Alice I, Nichols +2 more
openaire +2 more sources
The Combination of Population Pharmacokinetic Studies
Biometrics, 2000Summary.Pharmacokinetic data consist of drug concentrations with associated known sampling times and are collected following the administration of known dosage regimens. Population pharmacokinetic data consist of such data on a number of individuals, possibly along with individual‐specific characteristics.
Wakefield, Jonathan, Rahman, Nargis
openaire +2 more sources
Pharmacokinetics of Brodimoprim in Special Populations
Journal of Chemotherapy, 1993The pharmacokinetics of brodimoprim have been investigated after single oral dose administration in children, in healthy adults, and elderly subjects, as well as in patients with mild renal failure (creatinine clearance 40-70 mL/min) or liver insufficiency (Child-Pugh grade A or B). The plasma half-life increased moderately with age.
Stockis, A. +9 more
openaire +3 more sources
Clinical Pharmacokinetics, 1986
Good therapeutic practice should always be based on an understanding of pharmacokinetic variability. This ensures that dosage adjustments can be made to accommodate differences in pharmacokinetics due to genetic, environmental, physiological or pathological factors.
B, Whiting, A W, Kelman, J, Grevel
openaire +2 more sources
Good therapeutic practice should always be based on an understanding of pharmacokinetic variability. This ensures that dosage adjustments can be made to accommodate differences in pharmacokinetics due to genetic, environmental, physiological or pathological factors.
B, Whiting, A W, Kelman, J, Grevel
openaire +2 more sources
Population Pharmacokinetics and Pharmacodynamics
2006The treatment of children with medicinal products is an important scientific area. It is recognized that many medicines that are used extensively in pediatric patients are either unlicensed or off-label. This chapter and textbook will help pediatric health professionals effectively treat children with the most appropriate medicine with minimal side ...
openaire +2 more sources
Software for Population Pharmacokinetics and Pharmacodynamics
Clinical Pharmacokinetics, 1999Pharmacokinetic-pharmacodynamic modelling is being used increasingly as a tool in drug development because often in phase III clinical trials only sparse data are available for analysis and so a nonlinear mixed effects modelling approach has to be adopted. Specialist data analytical techniques and software are required to analyse such data.
openaire +3 more sources