Results 161 to 170 of about 5,388 (193)

Sequence Analysis of Proviral DNA of Porcine Endogenous Retroviruses

Transplantation Proceedings, 2005
Among all species analyzed, the domestic pig seems to be the most appropriate organ donor for xenotransplantation. Porcine endogenous retroviruses (PERVs) are present in genomes of all pigs and are capable of infecting human cells in vitro thus posing a serious threat for xenotransplantation procedures.
G, Machnik, D, Sypniewski, Z, Wydmuch, K, Cholewa, U, Mazurek, T, Wilczok, Z, Smorag, J, Pacha   +7 more
openaire   +2 more sources

Porcine endogenous retroviruses in xenotransplantation

2011
Book abstract: The first comprehensive single-source reference on the minipig, this accessible manual provides a resource for research scientists on the potential and use of the minipig as a model. Written by acknowledged experts in the field, and drawing on the authors’ global contacts and experience with regulatory authorities and the pharmaceutical ...
Scobie, Linda, Garkavenko, Olga
openaire   +3 more sources

Molecularly cloned porcine endogenous retroviruses replicate on human cells

Transplantation Proceedings, 2000
International ...
Tonjes, R.R., Czauderna, F., Fischer, Nicolas, Krach, U., Boller, K., Chardon, Patrick, Roel-Gaillard, C., Niebert, M., Scheef, G., Werner, A., Kurth, R.   +10 more
openaire   +3 more sources

Reliable Classification and Recombination Analysis of Porcine Endogenous Retroviruses

Virus Genes, 2005
Prevention of cross-species infection with porcine endogenous retroviruses (PERV) is crucial for xenotransplantation. Previous studies described the potential risk of infection for the PERV gamma1 subfamilies A, B and C. Replication competent PERV gamma1 proviruses designated to a particular subfamily and hybrid viruses originating from retroviral ...
Nikolai, Klymiuk, Bernhard, Aigner
openaire   +2 more sources

ACTIVATION OF PRIMARY PORCINE ENDOTHELIAL CELLS INDUCES RELEASE OF PORCINE ENDOGENOUS RETROVIRUSES

Transplantation, 2004
Endothelial cells form the interface between the porcine graft and the recipient and frequently become activated after xenotransplantation. To evaluate the safety of xenotransplantation further, we assessed the effect of cellular activation on the expression and release of porcine endogenous retroviruses from primary endothelial cells isolated from ...
Deirdre A, Cunningham, Gabriella J, Dos Santos Cruz, Xosé M, Fernández-Suárez, Alison J, Whittam, Christopher, Herring, Laura, Copeman, Andrew, Richards, Gillian A, Langford   +7 more
openaire   +2 more sources

Long terminal repeats of porcine endogenous retroviruses in Sus scrofa

Archives of Virology, 2007
Using PCR, sequencing, and bioinformatic approaches with the genomic DNAs of Korean pigs (domestic, wild, and hybrid with Yorkshire), twelve solitary PERV long terminal repeat elements were identified and analyzed. Structure analysis of the LTR elements indicated that they have different repeat sequences in the U3 region.
J-W, Huh, B-W, Cho, D-S, Kim, H-S, Ha, Y-N, Noh, J-M, Yi, W-H, Lee, H-S, Kim   +7 more
openaire   +2 more sources

[Endogenous porcine retroviruses and xenotransplantation].

Pathologie-biologie, 2000
Vertebrate DNA contains numerous genomes closely related to retroviruses, i.e. endogenous retroviruses. While most of the retroviruses are pathogenous, endogenous retroviruses have rarely been shown as such. Endogenous retroviruses, as most of the retroviruses, are able to cross 'species barriers'. Porcine endogenous retroviruses were described in 1974.
openaire   +2 more sources

Cell-binding properties of the envelope proteins of porcine endogenous retroviruses

Microbes and Infection, 2005
To examine the binding properties of the envelope glycoproteins of porcine endogenous retrovirus subgroups A and B (PERV-A and PERV-B), we produced two forms of soluble envelope proteins, termed Env-ST and Env-SU, using a baculovirus expression system.
Rie, Watanabe, Takayuki, Miyazawa, Yoshiharu, Matsuura   +2 more
openaire   +2 more sources

Porcine endogenous retroviruses and xenotransplantation.

Cellular and molecular life sciences : CMLS, 2009
Xenotransplantation is defined by the PHS as any procedure that involves the transplantation, implantation or infusion into a human recipient of either (a) live cells, tissues or organs from a nonhuman animal source, or (b) human body fluids, cells, tissues or organs that have had ex vivo contact with live nonhuman animal cells, tissues or organs ...
openaire   +1 more source

[Xenotranplantation and porcine endogenous retroviruses].

Virologie (Montrouge, France)
Xenotransplantation using pigs as the transplant source has the potential to resolve the severe shortage of human organ donors. Pig production is a very well controlled process and a high sanitary status for pig products is relatively easy to achieve allowing the production of pathogen free animals (SPF).
Yann, Moalic, Hélène, Félix, André, Jestin, Yannick, Blanchard   +3 more
openaire   +1 more source