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Expression of porcine endogenous retroviruses (PERV) in different organs of a pig

Virology, 2012
Porcine endogenous retroviruses (PERVs) represent a particular risk for xenotransplantation using pig cells, tissues or organs. PERVs are integrated in the genome of all pig strains and can be released as particles that infect human cells. We performed for the first time a systematic analysis of PERV expression in different organs of a miniature pig ...
Joachim Denner, Iris Bittmann
exaly   +3 more sources

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Porcine endogenous retroviruses in xenotransplantation

2011
Book abstract: The first comprehensive single-source reference on the minipig, this accessible manual provides a resource for research scientists on the potential and use of the minipig as a model. Written by acknowledged experts in the field, and drawing on the authors’ global contacts and experience with regulatory authorities and the pharmaceutical ...
Scobie, Linda, Garkavenko, Olga
openaire   +3 more sources

Sequence Analysis of Proviral DNA of Porcine Endogenous Retroviruses

Transplantation Proceedings, 2005
Among all species analyzed, the domestic pig seems to be the most appropriate organ donor for xenotransplantation. Porcine endogenous retroviruses (PERVs) are present in genomes of all pigs and are capable of infecting human cells in vitro thus posing a serious threat for xenotransplantation procedures.
G, Machnik, D, Sypniewski, Z, Wydmuch, K, Cholewa, U, Mazurek, T, Wilczok, Z, Smorag, J, Pacha   +7 more
openaire   +2 more sources

Inhibition of porcine endogenous retroviruses by RNA interference: increasing the safety of xenotransplantation [PDF]

Virology, 2004
Transplantation of porcine xenografts into human recipients is a realistic option to overcome the growing worldwide shortage of suitable allogeneic organs.
Alexander Karlas, Joachim Denner, Reinhard Kurth   +2 more
exaly   +2 more sources

Reliable Classification and Recombination Analysis of Porcine Endogenous Retroviruses

Virus Genes, 2005
Prevention of cross-species infection with porcine endogenous retroviruses (PERV) is crucial for xenotransplantation. Previous studies described the potential risk of infection for the PERV gamma1 subfamilies A, B and C. Replication competent PERV gamma1 proviruses designated to a particular subfamily and hybrid viruses originating from retroviral ...
Nikolai, Klymiuk, Bernhard, Aigner
openaire   +2 more sources

ACTIVATION OF PRIMARY PORCINE ENDOTHELIAL CELLS INDUCES RELEASE OF PORCINE ENDOGENOUS RETROVIRUSES

Transplantation, 2004
Endothelial cells form the interface between the porcine graft and the recipient and frequently become activated after xenotransplantation. To evaluate the safety of xenotransplantation further, we assessed the effect of cellular activation on the expression and release of porcine endogenous retroviruses from primary endothelial cells isolated from ...
Deirdre A, Cunningham, Gabriella J, Dos Santos Cruz, Xosé M, Fernández-Suárez, Alison J, Whittam, Christopher, Herring, Laura, Copeman, Andrew, Richards, Gillian A, Langford   +7 more
openaire   +2 more sources

Porcine endogenous retroviruses: no infection in patients treated with a bioreactor based on porcine liver cells

Journal of Clinical Virology, 2003
Acute liver failure (ALF) remains a disease with high mortality. Bioartificial liver support systems, which combine living cells of the liver in an extracorporeal circuit, have been successfully used in first clinical trials. The shortage of human organs to be used for bioreactors and the lack of safe and effective human liver cell lines have resulted ...
Katrin Zeilinger, Igor Sauer, Alexander Karlas   +2 more
exaly   +3 more sources

Molecularly cloned porcine endogenous retroviruses replicate on human cells

Transplantation Proceedings, 2000
International ...
Tonjes, R.R., Czauderna, F., Fischer, Nicolas, Krach, U., Boller, K., Chardon, Patrick, Roel-Gaillard, C., Niebert, M., Scheef, G., Werner, A., Kurth, R.   +10 more
openaire   +3 more sources

Long terminal repeats of porcine endogenous retroviruses in Sus scrofa

Archives of Virology, 2007
Using PCR, sequencing, and bioinformatic approaches with the genomic DNAs of Korean pigs (domestic, wild, and hybrid with Yorkshire), twelve solitary PERV long terminal repeat elements were identified and analyzed. Structure analysis of the LTR elements indicated that they have different repeat sequences in the U3 region.
J-W, Huh, B-W, Cho, D-S, Kim, H-S, Ha, Y-N, Noh, J-M, Yi, W-H, Lee, H-S, Kim   +7 more
openaire   +2 more sources

Cell-binding properties of the envelope proteins of porcine endogenous retroviruses

Microbes and Infection, 2005
To examine the binding properties of the envelope glycoproteins of porcine endogenous retrovirus subgroups A and B (PERV-A and PERV-B), we produced two forms of soluble envelope proteins, termed Env-ST and Env-SU, using a baculovirus expression system.
Rie, Watanabe, Takayuki, Miyazawa, Yoshiharu, Matsuura   +2 more
openaire   +2 more sources