Results 141 to 150 of about 2,540 (169)
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Cell-binding properties of the envelope proteins of porcine endogenous retroviruses
Microbes and Infection, 2005To examine the binding properties of the envelope glycoproteins of porcine endogenous retrovirus subgroups A and B (PERV-A and PERV-B), we produced two forms of soluble envelope proteins, termed Env-ST and Env-SU, using a baculovirus expression system.
Rie Watanabe +2 more
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Journal of Clinical Virology, 2003
Acute liver failure (ALF) remains a disease with high mortality. Bioartificial liver support systems, which combine living cells of the liver in an extracorporeal circuit, have been successfully used in first clinical trials. The shortage of human organs to be used for bioreactors and the lack of safe and effective human liver cell lines have resulted ...
Igor M Sauer +2 more
exaly +3 more sources
Acute liver failure (ALF) remains a disease with high mortality. Bioartificial liver support systems, which combine living cells of the liver in an extracorporeal circuit, have been successfully used in first clinical trials. The shortage of human organs to be used for bioreactors and the lack of safe and effective human liver cell lines have resulted ...
Igor M Sauer +2 more
exaly +3 more sources
The origin of porcine endogenous retroviruses (PERVs)
Archives of Virology, 2021Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs, and they produce viral particles that are able to infect human cells and therefore pose a special risk for xenotransplantation. In contrast to other pig microorganisms that also pose a risk, such as porcine cytomegalovirus and hepatitis E virus, PERVs cannot be eliminated
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Virology, 2004 Transplantation of porcine xenografts into human recipients is a realistic option to overcome the growing worldwide shortage of suitable allogeneic organs.
Alexander Karlas +2 more
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APOBEC3 Proteins and Porcine Endogenous Retroviruses
Transplantation Proceedings, 2008Xenotransplantation of porcine cells, tissues, and organs offers a solution to overcome the shortage of human donor materials. In addition to the immunological and physiological barriers, the existence of numerous porcine microorganisms including viruses poses a risk for xenozoonosis.
E, Dörrschuck, C, Münk, R R, Tönjes
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Porcine endogenous retroviruses in xenotransplantation
2011Book abstract: The first comprehensive single-source reference on the minipig, this accessible manual provides a resource for research scientists on the potential and use of the minipig as a model. Written by acknowledged experts in the field, and drawing on the authors’ global contacts and experience with regulatory authorities and the pharmaceutical ...
Scobie, Linda, Garkavenko, Olga
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Sequence Analysis of Proviral DNA of Porcine Endogenous Retroviruses
Transplantation Proceedings, 2005Among all species analyzed, the domestic pig seems to be the most appropriate organ donor for xenotransplantation. Porcine endogenous retroviruses (PERVs) are present in genomes of all pigs and are capable of infecting human cells in vitro thus posing a serious threat for xenotransplantation procedures.
G, Machnik +7 more
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Distribution and expression of porcine endogenous retroviruses in multi‐transgenic pigs generated for xenotransplantation [PDF]
Xenotransplantation, 2009 Background: Multi-transgenic pigs produced for use in xenotransplantation have to be screened for the presence and expression of porcine endogenous retroviruses (PERV) to select animals with low PERV load.
Barbara Kesler +2 more
exaly +2 more sources
Reliable Classification and Recombination Analysis of Porcine Endogenous Retroviruses
Virus Genes, 2005Prevention of cross-species infection with porcine endogenous retroviruses (PERV) is crucial for xenotransplantation. Previous studies described the potential risk of infection for the PERV gamma1 subfamilies A, B and C. Replication competent PERV gamma1 proviruses designated to a particular subfamily and hybrid viruses originating from retroviral ...
Nikolai, Klymiuk, Bernhard, Aigner
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ACTIVATION OF PRIMARY PORCINE ENDOTHELIAL CELLS INDUCES RELEASE OF PORCINE ENDOGENOUS RETROVIRUSES
Transplantation, 2004Endothelial cells form the interface between the porcine graft and the recipient and frequently become activated after xenotransplantation. To evaluate the safety of xenotransplantation further, we assessed the effect of cellular activation on the expression and release of porcine endogenous retroviruses from primary endothelial cells isolated from ...
Deirdre A, Cunningham +7 more
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