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Epigenetic mechanisms of retroviral regulation: a comparative review. [PDF]
Shin SY +3 more
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Diversity and evolutionary history of endogenous retroviruses in the genome of <i>Manis pentadactyla</i>. [PDF]
Zhang T, Xu J, Yang H, Zhou C, Zhang W.
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Phase separation of DUX family proteins drives totipotent-like state via 3D genome reorganization and retrotransposon activation. [PDF]
Gao L +14 more
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Current Techniques of Gene Editing in Pigs for Xenotransplantation. [PDF]
Galli C.
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Present Advances and Emerging Challenges in Kidney Xenotransplantation. [PDF]
Yamanaka K +10 more
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Liver Xenotransplantation: Ethical and Societal Implications. [PDF]
Hurst DJ +4 more
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Porcine endogenous retroviruses in xenotransplantation
ABSTRACT Xenotransplantation using pig cells, tissues or organs is under development to alleviate the shortage of human donor organs. Meanwhile, remarkably long survival times of pig organs in non-human primates have been reported, as well as the functionality of pig kidneys and hearts in brain-dead humans.
Joachim Denner
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The origin of porcine endogenous retroviruses (PERVs)
Archives of Virology, 2021Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs, and they produce viral particles that are able to infect human cells and therefore pose a special risk for xenotransplantation. In contrast to other pig microorganisms that also pose a risk, such as porcine cytomegalovirus and hepatitis E virus, PERVs cannot be eliminated
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APOBEC3 Proteins and Porcine Endogenous Retroviruses
Transplantation Proceedings, 2008Xenotransplantation of porcine cells, tissues, and organs offers a solution to overcome the shortage of human donor materials. In addition to the immunological and physiological barriers, the existence of numerous porcine microorganisms including viruses poses a risk for xenozoonosis.
E, Dörrschuck, C, Münk, R R, Tönjes
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