Results 111 to 120 of about 5,388 (193)

Porcine Endogenous Retroviruses Inhibit Human Immune Cell Function: Risk for Xenotransplantation?

Virology, 2000
Transgenic pigs are currently the most favored potential source of organs for xenotransplantation. Like all mammalian species they all harbor endogenous retroviruses in their genome. These porcine endogenous retroviruses (PERVs) are produced from several primary cells and cell lines and are able to infect human cells. Here we demonstrate that different
Tacke, Stefan J., Kurth, Reinhard, Denner, Joachim   +2 more
openaire   +2 more sources

Transcriptional and epigenetic control of cell fate decisions in early embryos [PDF]

, 2017
Mammalian embryo development is characterized by regulative mechanisms of lineage segregation and cell specification. A combination of carefully orchestrated gene expression networks, signalling pathways and epigenetic marks define specific developmental
Alberio, Ramiro
core   +2 more sources

Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals?

Retrovirology, 2018
Porcine endogenous retroviruses (PERVs) are present in the genome of all pigs, they infect certain human cells and therefore pose a special risk for xenotransplantation using pig cells, tissues and organs.
Joachim Denner
doaj   +1 more source

Screening for Viruses in Indigenous Greek Black Pigs

Microorganisms
The successful advancement of xenotransplantation has led to the development of highly sensitive detection systems for the screening of potentially zoonotic viruses in donor pigs and preventing their transmission to the recipient.
Hina Jhelum, Vasileios Papatsiros, Georgios Papakonstantinou, Ludwig Krabben, Benedikt Kaufer, Joachim Denner   +5 more
doaj   +1 more source

Absence of Neu5Gc and Presence of Anti-Neu5Gc Antibodies in Humans-An Evolutionary Perspective. [PDF]

, 2019
The glycocalyx of human cells differs from that of many other mammals by the lack of the sialic acid N-glycolylneuraminic acid (Neu5Gc) and increased abundance of its precursor N-acetylneuraminic acid (Neu5Ac).
Altman, Meghan O, Gagneux, Pascal
core   +1 more source

Microbiological safety of a novel bio-artificial liver support system based on porcine hepatocytes: a experimental study

European Journal of Medical Research, 2012
Background Our institute has developed a novel bio-artificial liver (BAL) support system, based on a multi-layer radial-flow bioreactor carrying porcine hepatocytes and mesenchymal stem cells.
Han Bing, Shi Xiao-lei, Zhang Yue, Chu Xue-hui, Gu Jin-yang, Xiao Jiang-qiang, Ren Hao-zhen, Tan Jia-jun, Gu Zhong-ze, Ding Yi-tao   +9 more
doaj   +1 more source

AN69 Hollow Fiber Membrane will Reduce but Not Abolish the Risk of Transmission of Porcine Endogenous Retroviruses

Cell Transplantation, 2005
As the risk of porcine endogenous retrovirus (PERV) infection is a major obstacle to the xenotransplantation of porcine tissue, we investigated whether an AN69 hollow fibre membrane, used for islets of Langerhans transplantation, could prevent the ...
Oleg Pakhomov, Lionel Martignat, Jiri Honiger, Béatrice Clémenceau, Pierre Säi, Sylviane Darquy Ph.D.   +5 more
doaj   +1 more source

Is it currently possible to evaluate the risk posed by PERVs for clinical xenotransplantation? [PDF]

, 2018
Denner, Joachim, Schuurman, Henk-Jan, Scobie, Linda   +2 more
core   +1 more source

Viral pathogens: what are they and do they matter? [PDF]

, 2018
Andrea Perota, Cesare Galli, Claire Crossan, Cooper, Cooper, Crossan, Crossan, Denner, Denner, Denner, Denner, Denner, Denner, Fishman, Fishman, Gazda, Guell, Irwin, Linda Scobie, Morozov, Mourad, Nicuolo, Nizar I. Mourad, Onions, Paradis, Pierre Gianello, Scobie, Scobie, Spizzo, Wynyard, Yang   +30 more
core   +1 more source

Virus safety of xenotransplantation and porcine endogenous retroviruses (PERVs)

, 2014
Introduction: The shortage of organs for patients is an issue that needs addressing. Xenotransplantation using pig cells or organs is the most favored option. However, pigs contain porcine endogenous retroviruses (PERV) in their genome which infect human cells. Like all retroviruses PERVs have immunosuppressive properties and may induce tumors.
openaire   +3 more sources