Results 91 to 100 of about 2,540 (169)

Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5  proteins including human TRIM5

, 2009
The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5{
Takeuchi, Y., Schaller, T., Towers, G. J., Wood, A., Webb, B. L. J., Bartosch, B.   +5 more
core  

Detection of a gammaretrovirus, XMRV, in the human population: Open questions and implications for xenotransplantation

Retrovirology, 2010
XMRV (xenotropic murine leukaemia virus-related virus) is a gammaretrovirus that has been detected in human patients with prostate carcinoma, chronic fatigue syndrome (CFS) and also in a small percentage of clinically healthy individuals.
Denner Joachim
doaj   +1 more source

PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy

Advanced Science, Volume 13, Issue 20, 9 April 2026.
The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao, Lijuan Lu, Xiaoxiao Xiong, Yi Li, Donghui Hu, Duo Zhang, Zhiwei Feng, Cong Liu, Nannan Liu, Xiaoli Li, Jizhou Tan, Ting Liu, Ling Peng, Lu Lu, Huiyi Feng, Yan Zhong, Guisen Tan, Zhicheng Zhang, Liqin Huang, Chao Su, Ying Xue, Shuo Song, Wenxia Fan, Wei Wang, Fan Zou   +24 more
wiley   +1 more source

The Detection and Role of Human Endogenous Retrovirus K (HML-2) In Rheumatoid Arthritis [PDF]

, 2008
A thesis submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of PhilosophyHuman endogenous retroviruses are the remnants of ancient retroviral infections present within our genome.
Freimanis, Graham L.
core  

Concise classification of the genomic porcine endogenous retroviral γ1 load to defined lineages

, 2008
We investigated the infection history of porcine endogenous retroviruses (PERV) γ1 by analyzing published env and LTR sequences. PERV sequences from various breeds, porcine cell lines and infected human primary cells were included in the study.
Klymiuk, Nikolai, Wolf, Eckhard, Aigner, Bernhard   +2 more
core   +1 more source

A Comprehensive Strategy for Screening for Xenotransplantation-Relevant Viruses in a Second Isolated Population of Göttingen Minipigs

Viruses, 2019
Xenotransplantation using pig tissues and organs is under development in order to alleviate the increasing shortage of human transplants. Since xenotransplantation may be associated with the transmission of porcine microorganisms to the human recipient ...
Luise Krüger, Yannick Kristiansen, Emelie Reuber, Lars Möller, Michael Laue, Christian Reimer, Joachim Denner   +6 more
doaj   +1 more source

The Japanese Macaque as a Diabetes Recipient Animal Model for Porcine Islet Xenotransplantation

MedComm, Volume 7, Issue 4, April 2026.
Porcine islet xenotransplantation is effective for severe diabetes; however, preclinical studies are essential. In this study, we evaluated the suitability of the Japanese macaque as a recipient model for islet xenotransplantation, including identifying the preferred method to induce diabetes.
Naoaki Sakata, Gumpei Yoshimatsu, Ryo Kawakami, Seiichi Tanaka, Shohta Kodama   +4 more
wiley   +1 more source

Cell entry and exit of porcine endogenous retrovirus A: receptors and release inhibitor

, 2010
Following the discovery that porcine endogenous retrovirus (PERV) can infect human cells, the potential risk of a zoonotic infection by PERV has been a major obstacle in the xenotransplantation field.
Mattiuzzo, G.
core  

Xenotransplantation: where do we stand in 2016?

Swiss Medical Weekly, 2017
Worldwide, there is a constant rise in the number of patients with end-stage organ failure in critical need for transplants, but the number of organs/cells available from deceased or living human donors is limited.
Gisella L. Yung Puga, Robert Rieben, Leo Bühler, Henk-Jan Schuurman, Jörg D. Seebach   +4 more
doaj   +1 more source

Genomic insights into evolutionary journey of the porcine endogenous retroviruses [PDF]

, 2018
Abstract Background Xenotransplantation may overcome significant shortage of human allotransplant. Porcine organs are considered favorable for xenotransplantation duo to similar size and function to human organ.
Chen, Yicong, Chen, Mingyue, Duan, Xiaoyan, Cui, Jie   +3 more
openaire   +1 more source