Results 91 to 100 of about 517,815 (166)

Human Endogenous retroviruses [PDF]

, 2018
Human Endogenous retroviruses (HERVs) occupy nearly 8%25 of human genome. They are thought to be remnants of retroviruses. These integrated elements have gag, pol and env coding regions.
GÖZÜKIRMIZI, Nermin, Buket Çakmak Güner, Nermin Gözükırmızı, Çakmak, Buket   +3 more
core   +1 more source

Lack of antibody response in pigs immunized with the transmembrane envelope protein of porcine endogenous retroviruses

, 2014
Recently we immunised different mammalian species (goats, mice, rats, rabbits, guinea pigs, hamsters) with the recombinant ectodomain of the transmembrane envelope (TM) protein p15E of the porcine endogenous retrovirus (PERV).
Keller, Martina, Petersen, Björn, Niemann, Heiner, Denner, Joachim   +3 more
core   +1 more source

Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals?

Retrovirology, 2018
Porcine endogenous retroviruses (PERVs) are present in the genome of all pigs, they infect certain human cells and therefore pose a special risk for xenotransplantation using pig cells, tissues and organs.
Joachim Denner
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Characterization of germline porcine endogenous retroviruses from Large White pig

Journal of General Virology, 2004
Porcine endogenous retroviruses (PERV) are of concern when the microbiological safety aspects of xenotransplantation are considered. Four unique isolates of PERV B have been identified previously from a lambda library constructed from genomic DNA from a Large White pig.
Scobie, Linda, Taylor, Samantha, Logan, Nicola A., Meikle, Sharon, Onions, David, Patience, Clive, Quinn, Gary   +6 more
openaire   +2 more sources

Identification of a novel type C porcine endogenous retrovirus: evidence that copy number of endogenous retroviruses increases during host inbreeding

, 2001
Different classes of porcine endogenous retroviruses (PERVs), which have the potential to infect humans during xenotransplantation, have been isolated from the pig genome.
Mang, R., Maas, J., Goudsmit, J., Chen, X., van der Kuyl, A. C.   +4 more
core   +1 more source

Concise classification of the genomic porcine endogenous retroviral γ1 load to defined lineages [PDF]

, 2008
We investigated the infection history of porcine endogenous retroviruses (PERV) γ1 by analyzing published env and LTR sequences. PERV sequences from various breeds, porcine cell lines and infected human primary cells were included in the study.
Klymiuk, Nikolai, Wolf, Eckhard, Aigner, Bernhard   +2 more
core   +1 more source

Screening for Viruses in Indigenous Greek Black Pigs

Microorganisms
The successful advancement of xenotransplantation has led to the development of highly sensitive detection systems for the screening of potentially zoonotic viruses in donor pigs and preventing their transmission to the recipient.
Hina Jhelum, Vasileios Papatsiros, Georgios Papakonstantinou, Ludwig Krabben, Benedikt Kaufer, Joachim Denner   +5 more
doaj   +1 more source

Microbiological safety of a novel bio-artificial liver support system based on porcine hepatocytes: a experimental study

European Journal of Medical Research, 2012
Background Our institute has developed a novel bio-artificial liver (BAL) support system, based on a multi-layer radial-flow bioreactor carrying porcine hepatocytes and mesenchymal stem cells.
Han Bing, Shi Xiao-lei, Zhang Yue, Chu Xue-hui, Gu Jin-yang, Xiao Jiang-qiang, Ren Hao-zhen, Tan Jia-jun, Gu Zhong-ze, Ding Yi-tao   +9 more
doaj   +1 more source

AN69 Hollow Fiber Membrane will Reduce but Not Abolish the Risk of Transmission of Porcine Endogenous Retroviruses

Cell Transplantation, 2005
As the risk of porcine endogenous retrovirus (PERV) infection is a major obstacle to the xenotransplantation of porcine tissue, we investigated whether an AN69 hollow fibre membrane, used for islets of Langerhans transplantation, could prevent the ...
Oleg Pakhomov, Lionel Martignat, Jiri Honiger, Béatrice Clémenceau, Pierre Säi, Sylviane Darquy Ph.D.   +5 more
doaj   +1 more source