Results 71 to 80 of about 3,386 (182)

The restriction of zoonotic PERV transmission by human APOBEC3G. [PDF]

PLoS ONE, 2007
The human APOBEC3G protein is an innate anti-viral factor that can dominantly inhibit the replication of some endogenous and exogenous retroviruses. The prospects of purposefully harnessing such an anti-viral defense are under investigation.
Stefán R Jónsson, Rebecca S LaRue, Mark D Stenglein, Scott C Fahrenkrug, Valgerdur Andrésdóttir, Reuben S Harris   +5 more
doaj   +1 more source

Establishment of Interspecies Somatic Cell Nuclear Transfer and Transgene‐Free Inducible Pluripotent Stem Cells for Versatile Conservation of the Germplasm Resource of Wild Boar

Animal Research and One Health, EarlyView.
Conserving genetic material and even increasing genetic diversity is critical. To conduct the conservation of wild boar germplasm resources, we have successfully obtained healthy cloned wild boars for the first time using interspecies somatic cell nuclear transfer and established transgene‐free iPSCs that can be used to conduct iterative rounds of gene
Chen Gao, Xinyi Zhou, Shigang Gu, Jianbo Li, Jing Wang, Yurong Zhang, Wenxuan Zhao, Xinhua Wei, Liting Lu, Quanmin Zhao, Yongye Huang, Dawei Yu   +11 more
wiley   +1 more source

Intracellularly expressed single-domain antibody against p15 matrix protein prevents the production of porcine retroviruses [PDF]

, 2003
The presence of porcine endogenous retroviruses presents a potential risk of transmission of infectious diseases (xenozoonosis) if tissues and organs from genetically modified pigs are to be used in xenotransplantation.
Ton de Wit, Wendy Toussaint, Visser, P. (Pim), Wit, A.P.M. (Ton) de, Pim Visser, Frank Grosveld, Drabek, D.D. (Dubravka), Dekker, S. (Sylvia), Panayotou, G. (George), George Panayotou, Dubravka Drabek, Toussaint, W. (Wendy), Sylvia Dekker, Grosveld, F.G. (Frank)   +13 more
core   +1 more source

Natural Antibodies Prevent in Vivo Transmission of Porcine Islet-Derived Endogenous Retrovirus to Human Cells

Cell Transplantation, 2004
The discovery of porcine endogenous retroviruses (PERV) has raised concerns regarding the safety of porcine xenotransplantation. However, transmission of PERV had not been observed in humans exposed to porcine tissue.
Brice W. Mckane, Sabarinathan Ramachandran, Xiao-Chun Xu, Barbara J. Olack, William C. Chapman, T. Mohanakumar Ph.D.   +5 more
doaj   +1 more source

Genotyping of Porcine Endogenous Retroviruses from a Family of Miniature Swine [PDF]

Journal of Virology, 2004
ABSTRACT The identification of animals in an inbred miniature swine herd that consistently fail to produce replication- competent humantropic porcine endogenous retrovirus (PERV) has prompted studies on the biology of PERV in transmitter and nontransmitter animals.
Gary, Quinn, James, Wood, Kristen, Suling, Scott, Arn, David H, Sachs, Henk-Jan, Schuurman, Clive, Patience   +6 more
openaire   +2 more sources

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Genetically engineered pigs for xenotransplantation: Hopes and challenges

Frontiers in Cell and Developmental Biology, 2023
The shortage of donor resources has greatly limited the application of clinical xenotransplantation. As such, genetically engineered pigs are expected to be an ideal organ source for xenotransplantation.
Jiahui Xi, Wei Zheng, Min Chen, Qingjian Zou, Chengcheng Tang, Xiaoqing Zhou   +5 more
doaj   +1 more source

Recombination analysis of human-tropic porcine endogenous retroviruses

Journal of General Virology, 2003
Prevention of cross-species infection of porcine endogenous retroviruses (PERV) is crucial for xenotransplantation. The potential risk of infection is caused by replication-competent PERV as well as by hybrid viruses derived from recombination events of distinct PERV genomes.
Nikolai, Klymiuk, Mathias, Müller, Gottfried, Brem, Bernhard, Aigner   +3 more
openaire   +2 more sources

Gene Therapy and Gene Editing in Type 1 Diabetes: CRISPR‐Based β‐Cell Replacement and Treg Immune Modulation Approaches

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5476-5491, July 2026.
ABSTRACT Background Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease marked by the destruction of pancreatic β‐cells, resulting in lifelong dependence on exogenous insulin. Despite advances in insulin delivery and glucose monitoring technologies, patients remain at risk for acute and long‐term complications, underscoring the need for ...
Tzu‐Min Lin, Hui‐Fang Chang, Tzu‐Ching Lin, Cheng‐Han Lin, Yu‐Ling Sun, Chih‐Sheng Lin   +5 more
wiley   +1 more source

Limited environmental stability of infectious porcine endogenous retrovirus type C; Usage of reverse transcriptase in combination with viral RNA as markers for infectious virus

Xenotransplantation, 2022
Porcine endogenous retroviruses (PERVs) are an integral part of the pig genome with infectious potential, as shown in vitro.
N. Fischer, Barbara Gulich, R. Tönjes, Antonia W Godehardt   +3 more
semanticscholar   +1 more source