Results 71 to 80 of about 5,388 (193)

Genetically engineered pigs for xenotransplantation: Hopes and challenges

Frontiers in Cell and Developmental Biology, 2023
The shortage of donor resources has greatly limited the application of clinical xenotransplantation. As such, genetically engineered pigs are expected to be an ideal organ source for xenotransplantation.
Jiahui Xi, Wei Zheng, Min Chen, Qingjian Zou, Chengcheng Tang, Xiaoqing Zhou   +5 more
doaj   +1 more source

Polymicrobial periodontal disease triggers a wide radius of effect and unique virome. [PDF]

, 2020
Periodontal disease is a microbially-mediated inflammatory disease of tooth-supporting tissues that leads to bone and tissue loss around teeth. Although bacterially-mediated mechanisms of alveolar bone destruction have been widely studied, the effects of
Gao, Li, Ho, Sunita P, Kamarajan, Pachiyappan, Kang, Misun, Kapila, Yvonne L, Kuraji, Ryutaro, Le, Charles, Martinez, April, Rangé, Hélène, Reza Sailani, M, Ye, Changchang, Zhan, Ling, Zhang, Martin Jinye   +12 more
core  

Gene Therapy and Gene Editing in Type 1 Diabetes: CRISPR‐Based β‐Cell Replacement and Treg Immune Modulation Approaches

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease marked by the destruction of pancreatic β‐cells, resulting in lifelong dependence on exogenous insulin. Despite advances in insulin delivery and glucose monitoring technologies, patients remain at risk for acute and long‐term complications, underscoring the need for ...
Tzu‐Min Lin, Hui‐Fang Chang, Tzu‐Ching Lin, Cheng‐Han Lin, Yu‐Ling Sun, Chih‐Sheng Lin   +5 more
wiley   +1 more source

Generation of neutralising antibodies against porcine endogenous retroviruses (PERVs)

Virology, 2011
Antibodies neutralising porcine endogenous retroviruses (PERVs) were induced in different animal species by immunisation with the transmembrane envelope protein p15E. These antibodies recognised epitopes, designated E1, in the fusion peptide proximal region (FPPR) of p15E, and E2 in the membrane proximal external region (MPER).
Kaulitz, Danny, Fiebig, Uwe, Eschricht, Magdalena, Wurzbacher, Christian, Kurth, Reinhard, Denner, Joachim   +5 more
openaire   +2 more sources

A Natural LTR Retrotransposon Insertion in the Promoter of GhNAC140‐Dt Boosts Cotton Lint Yield

Plant Biotechnology Journal, EarlyView.
ABSTRACT Transposable elements (TEs) are fundamental drivers of crop evolution and domestication. Whereas the underlying mechanisms of TE‐mediated gene activation remain poorly understood. Lint percentage is an important yield component in cotton. Here, we report a retrotransposon insertion in the promoter of GhNAC140‐Dt, a secondary wall NAC encoding ...
Yujia Yu, Xiaoguang Shang, Haitang Wang, Lijie Zhu, Xu Han, Qingfei He, Weixi Li, Yonglin Tan, Guozhong Zhu, Wangzhen Guo   +9 more
wiley   +1 more source

Characterization of germline porcine endogenous retroviruses from Large White pig

Journal of General Virology, 2004
Porcine endogenous retroviruses (PERV) are of concern when the microbiological safety aspects of xenotransplantation are considered. Four unique isolates of PERV B have been identified previously from a lambda library constructed from genomic DNA from a Large White pig.
Scobie, Linda, Taylor, Samantha, Logan, Nicola A., Meikle, Sharon, Onions, David, Patience, Clive, Quinn, Gary   +6 more
openaire   +2 more sources

A metagenomic comparison of endemic viruses from broiler chickens with runting stunting syndrome and from normal birds [PDF]

, 2016
Runting-stunting syndrome (RSS) in broiler chickens is an enteric disease that causes significant economic losses to poultry producers worldwide due to elevated feed conversion ratios, decreased body weight during growth, and excessive culling.
Devaney, Ryan, Meharg, Caroline, Smyth, Victoria, Trudgett, Alan, Trudgett, James   +4 more
core   +1 more source

Mapping Full-Length Porcine Endogenous Retroviruses in a Large White Pig [PDF]

Journal of Virology, 2001
ABSTRACT Xenotransplantation may bridge the widening gap between the shortage of donor organs and the increasing number of patients waiting for transplantation. However, a major safety issue is the potential cross-species transmission of porcine endogenous retroviruses (PERV).
C, Herring, G, Quinn, R, Bower, N, Parsons, N A, Logan, A, Brawley, K, Elsome, A, Whittam, X M, Fernandez-Suarez, D, Cunningham, D, Onions, G, Langford, L, Scobie   +12 more
openaire   +2 more sources

Can Antiretroviral Drugs Be Used to Treat Porcine Endogenous Retrovirus (PERV) Infection after Xenotransplantation?

Viruses, 2017
Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs; they are released as infectious particles, and under certain conditions they can infect human cells. Therefore, they represent a risk when pigs are used as sources of cells,
Joachim Denner
doaj   +1 more source

Xenoperfusion—The Transformative Role of Machine Perfusion in Xenotransplantation

Xenotransplantation, Volume 33, Issue 3, May/June 2026.
ABSTRACT Recent advances in xenotransplantation have gained substantial public and clinical attention as genetically modified porcine organs are now being transplanted into living human recipients. While only case reports have been published to date, the first clinical trials for kidney xenotransplantation are now ongoing.
Florian Huwyler, Simon Stoerzer, Pierre‐Alain Clavien, Mark W. Tibbitt   +3 more
wiley   +1 more source