PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy
Advanced Science, Volume 13, Issue 20, 9 April 2026.The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao +24 more
wiley +1 more source
Genotyping of Porcine Endogenous Retroviruses from a Family of Miniature Swine [PDF]
Journal of Virology, 2004 ABSTRACT The identification of animals in an inbred miniature swine herd that consistently fail to produce replication- competent humantropic porcine endogenous retrovirus (PERV) has prompted studies on the biology of PERV in transmitter and nontransmitter animals.
Gary, Quinn +6 more
openaire +2 more sources
The Japanese Macaque as a Diabetes Recipient Animal Model for Porcine Islet Xenotransplantation
MedComm, Volume 7, Issue 4, April 2026.Porcine islet xenotransplantation is effective for severe diabetes; however, preclinical studies are essential. In this study, we evaluated the suitability of the Japanese macaque as a recipient model for islet xenotransplantation, including identifying the preferred method to induce diabetes.
Naoaki Sakata +4 more
wiley +1 more source
Antiretroviral Agents Inhibit Infection of Human Cells by Porcine Endogenous Retroviruses [PDF]
Antimicrobial Agents and Chemotherapy, 2000 ABSTRACT The efficacy of antiretroviral drugs against porcine endogenous retroviruses (PERV) that may be harbored in pig organs intended for transplantation was examined in human cells in vitro. The nucleoside analogs zidovudine and dideoxyinosine were found to effectively inhibit PERV replication.
S K, Powell +6 more
openaire +2 more sources
Potential for clinical pancreatic islet xenotransplantation [PDF]
, 2014 Diabetes mellitus is increasing worldwide. Type 1 diabetes can be treated successfully by islet allotransplantation, the results of which are steadily improving.
Bottino, R +6 more
core +1 more source
Xenotransplantation Literature Update: July–December 2025
Xenotransplantation, Volume 33, Issue 2, March/April 2026.ABSTRACT The second half of 2025 marked a significant transition for xenotransplantation, shifting further from experimental feasibility to early clinical translation. Prolonged physiologic support from genetically engineered porcine kidneys and livers in human recipients provided unprecedented insight into organ compatibility, rejection dynamics, and ...
Kasra Shirini +3 more
wiley +1 more source
Porcine endogenous retroviruses in xenotransplantation
Nephrology Dialysis TransplantationABSTRACT Xenotransplantation using pig cells, tissues or organs is under development to alleviate the shortage of human donor organs. Meanwhile, remarkably long survival times of pig organs in non-human primates have been reported, as well as the functionality of pig kidneys and hearts in brain-dead humans.
openaire +2 more sources
Frontiers in Immunology, 2018 Genetically modified pigs have been considered favorable resources in xenotransplantation. Microinjection of randomly integrating transgenes into zygotes, somatic cell nuclear transfer, homologous recombination, zinc finger nucleases, transcription ...
Meisam Naeimi Kararoudi +7 more
doaj +1 more source
Type W Human Endogenous Retrovirus (HERV-W) Integrations and Their Mobilization by L1 Machinery: Contribution to the Human Transcriptome and Impact on the Host Physiopathology [PDF]
, 2017 Human Endogenous Retroviruses (HERVs) are ancient infection relics constituting ~8% of our DNA. While HERVs' genomic characterization is still ongoing, impressive amounts of data have been obtained regarding their general expression across tissues. Among
Grandi, Nicole, Tramontano, Enzo
core +1 more source
Xenotransplantation at a Crossroads: Breakthroughs, Challenges, and the Path Forward
Organ Medicine, EarlyView.
Xiaoyu Gan +3 more
wiley +1 more source