Results 81 to 90 of about 517,815 (166)
Ethical Considerations in Islet Xenotransplantation
Xenotransplantation, Volume 33, Issue 4, July/August 2026.ABSTRACT For the management of type 1 diabetes, islet xenotransplantation has emerged as a potential alternative to lifelong insulin therapy or islet allotransplantation. However, this progress raises significant ethical questions that warrant further exploration.
Daniel J. Hurst +6 more
wiley +1 more source
Genome-wide inactivation of porcine endogenous retroviruses (PERVs)
, 2017 The shortage of organs for transplantation is a major barrier to the treatment of organ failure. While porcine organs are considered promising, their use has been checked by concerns about transmission of porcine endogenous retroviruses (PERVs) to humans.
Niu, D. +13 more
core +1 more source
Intracellularly expressed single-domain antibody against p15 matrix protein prevents the production of porcine retroviruses [PDF]
, 2003 The presence of porcine endogenous retroviruses presents a potential risk of transmission of infectious diseases (xenozoonosis) if tissues and organs from genetically modified pigs are to be used in xenotransplantation.
Ton de Wit +13 more
core +2 more sources
Retrovirology, 2010 XMRV (xenotropic murine leukaemia virus-related virus) is a gammaretrovirus that has been detected in human patients with prostate carcinoma, chronic fatigue syndrome (CFS) and also in a small percentage of clinically healthy individuals.
Denner Joachim
doaj +1 more source
Genomic insights into evolutionary journey of the porcine endogenous retroviruses [PDF]
, 2018 Abstract Background Xenotransplantation may overcome significant shortage of human allotransplant. Porcine organs are considered favorable for xenotransplantation duo to similar size and function to human organ.
Chen, Yicong +3 more
openaire +1 more source
Xenotransplantation Literature Update: January–June 2026
Xenotransplantation, Volume 33, Issue 4, July/August 2026.ABSTRACT In the first half of 2026, xenotransplantation advanced through refinement rather than dramatic new clinical milestones. Clinical studies described graft physiology, immune infiltration, complement activation, coagulation incompatibility, and early function in living recipients, decedent models, and clinical islet xenotransplantation ...
Kasra Shirini +3 more
wiley +1 more source
Viruses, 2019 Xenotransplantation using pig tissues and organs is under development in order to alleviate the increasing shortage of human transplants. Since xenotransplantation may be associated with the transmission of porcine microorganisms to the human recipient ...
Luise Krüger +6 more
doaj +1 more source
Porcine kidney xenotransplantation: From primate models to clinical reality
Animal Models and Experimental Medicine, Volume 9, Issue 6, Page 1142-1166, June 2026.In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo +3 more
wiley +1 more source
Xenotransplantation: where do we stand in 2016?
Swiss Medical Weekly, 2017 Worldwide, there is a constant rise in the number of patients with end-stage organ failure in critical need for transplants, but the number of organs/cells available from deceased or living human donors is limited.
Gisella L. Yung Puga +4 more
doaj +1 more source
Artificial Cells for the Development of Cell Therapy
Cell Transplantation, 2008 In developing cell therapy, normal human cells are ideal as a cell source, but considering the serious lack of donor organs, it is unlikely to obtain a large enough amount of human cells.
Naoya Kobayashi
doaj +1 more source