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The use of transgenic animals for xenotransplantation: An update
Animal Models and Experimental Medicine, Volume 8, Issue 11, Page 2041-2052, November 2025.One way to produce genetically modified pigs is to use somatic cell nuclear transfer (SCNT). This procedure involves removing the metaphase plate from a mature oocyte using micromanipulation and then transferring the modified nucleus from the donor somatic cell to the oocyte.
Julia Motławska +3 more
wiley +1 more source
Viruses, 2019 Xenotransplantation using pig tissues and organs is under development in order to alleviate the increasing shortage of human transplants. Since xenotransplantation may be associated with the transmission of porcine microorganisms to the human recipient ...
Luise Krüger +6 more
doaj +1 more source
Stem Cell Imaging: Tools to Improve Cell Delivery and Viability. [PDF]
, 2016 Stem cell therapy (SCT) has shown very promising preclinical results in a variety of regenerative medicine applications. Nevertheless, the complete utility of this technology remains unrealized. Imaging is a potent tool used in multiple stages of SCT and
Jokerst, Jesse V, Wang, Junxin
core +3 more sources
Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro +5 more
wiley +1 more source
A novel minimal in vitro system for analyzing HIV-1 Gag mediated budding
, 2014 A biomimetic minimalist model membrane was used to study the mechanism and kinetics of cell-free in vitro HIV-1 Gag budding from a giant unilamellar vesicle (GUV).
Gill, Sarjeet +7 more
core +1 more source
Endogenous Retrovirus Insertion in the KIT Oncogene Determines White and White spotting in Domestic Cats [PDF]
, 2014 The Dominant White locus (W) in the domestic cat demonstrates pleiotropic effects exhibiting complete penetrance for absence of coat pigmentation and incomplete penetrance for deafness and iris hypopigmentation.
Connelly, Catherine J. +12 more
core +2 more sources
Xenotransplantation: where do we stand in 2016?
Swiss Medical Weekly, 2017 Worldwide, there is a constant rise in the number of patients with end-stage organ failure in critical need for transplants, but the number of organs/cells available from deceased or living human donors is limited.
Gisella L. Yung Puga +4 more
doaj +1 more source
Key determinants of target DNA recognition by retroviral intasomes [PDF]
, 2015 BACKGROUND: Retroviral integration favors weakly conserved palindrome sequences at the sites of viral DNA joining and generates a short (4–6 bp) duplication of host DNA flanking the provirus.
Ballandras-Colas, A +4 more
core +2 more sources
Artificial Cells for the Development of Cell Therapy
Cell Transplantation, 2008 In developing cell therapy, normal human cells are ideal as a cell source, but considering the serious lack of donor organs, it is unlikely to obtain a large enough amount of human cells.
Naoya Kobayashi
doaj +1 more source
Detection of infectious baboon cytomegalovirus after baboon-to-human liver xenotransplantation [PDF]
, 2001 Xenotransplantation is considered to be a solution for the human donor shortage. However, there is a potential risk of transmitting animal infections from the transplanted organ.
Jenkins, FJ +5 more
core +1 more source