High Prevalence of Recombinant Porcine Endogenous Retroviruses (PERV-A/Cs) in Minipigs: A Review on Origin and Presence [PDF]
Viruses, 2021 Minipigs play an important role in biomedical research and they have also been used as donor animals for preclinical xenotransplantations. Since zoonotic microorganisms including viruses can be transmitted when pig cells, tissues or organs are ...
Joachim Denner, Hendrik Jan Schuurman
doaj +8 more sources
Rare isolation of human-tropic recombinant porcine endogenous retroviruses PERV-A/C from Göttingen minipigs [PDF]
Virology Journal, 2022 Background Porcine endogenous retroviruses (PERVs) can infect human cells and pose a risk for xenotransplantation when pig cells, tissues or organs are transplanted to human recipients.
Sabrina Halecker +9 more
doaj +14 more sources
Determination of the Copy Number of Porcine Endogenous Retroviruses (PERV) in Auckland Island Pigs Repeatedly Used for Clinical Xenotransplantation and Elimination of PERV-C [PDF]
Microorganisms, 2023 Auckland Island pigs represent an inbred population of feral pigs isolated on the sub-Antarctic island for over 100 years. The animals have been maintained under pathogen-free conditions in New Zealand; they are well characterized virologically and have ...
Uwe Fiebig +2 more
doaj +8 more sources
Neutralizing Antibodies Against the Porcine Endogenous Retroviruses (PERVs) [PDF]
VirusesXenotransplantation using pig cells, tissues or organs may be associated with the transmission of porcine zoonotic or xenozoonotic microorganisms. Porcine endogenous retroviruses (PERVs) pose a special risk for xenotransplantation as these viruses can ...
Jinzhao Ban +3 more
doaj +3 more sources
Monitoring for PERV Following Xenotransplantation [PDF]
Transplant InternationalPorcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs. PERV-A, PERV-B and PERV-C can be released as infectious virus particles and PERV-A and PERV-B can infect human cells in culture.
Joachim Denner
doaj +5 more sources
Porcine Endogenous Retroviruses and Xenotransplantation, 2021 [PDF]
Viruses, 2021 Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs, and some of them are able to infect human cells. Therefore, PERVs pose a risk for xenotransplantation, the transplantation of pig cells, tissues, or organ to humans in ...
Joachim Denner
doaj +5 more sources
Differential resistance to cell entry by porcine endogenous retrovirus subgroup A in rodent species [PDF]
Retrovirology, 2007 Background The risk of zoonotic infection by porcine endogenous retroviruses (PERV) has been highlighted in the context of pig-to-human xenotransplantation. The use of receptors for cell entry often determines the host range of retroviruses.
Takeuchi Yasuhiro +2 more
doaj +3 more sources
Cytotoxic Effects during Knock Out of Multiple Porcine Endogenous Retrovirus (PERV) Sequences in the Pig Genome by Zinc Finger Nucleases (ZFN). [PDF]
PLoS ONE, 2015 Xenotransplantation has been proposed as a solution to the shortage of suitable human donors for transplantation and pigs are currently favoured as donor animals.
Marwan Semaan +2 more
doaj +11 more sources
Virological and Parasitological Characterization of Mini-LEWE Minipigs Using Improved Screening Methods and an Overview of Data on Various Minipig Breeds [PDF]
Microorganisms, 2021 Minipigs play an important role in biomedical research and have also been used as donor animals in xenotransplantation. To serve as a donor in xenotransplantation, the animals must be free of potential zoonotic viruses, bacteria and parasites.
Sabrina Halecker +5 more
doaj +4 more sources
Virus Safety of Xenotransplantation [PDF]
Viruses, 2022 The practice of xenotransplantation using pig islet cells or organs is under development to alleviate the shortage of human donor islet cells or organs for the treatment of diabetes or organ failure.
Joachim Denner
doaj +4 more sources