Results 1 to 10 of about 516,407 (164)

High Prevalence of Recombinant Porcine Endogenous Retroviruses (PERV-A/Cs) in Minipigs: A Review on Origin and Presence [PDF]

Viruses, 2021
Minipigs play an important role in biomedical research and they have also been used as donor animals for preclinical xenotransplantations. Since zoonotic microorganisms including viruses can be transmitted when pig cells, tissues or organs are ...
Joachim Denner, Hendrik Jan Schuurman
doaj   +9 more sources

Reliable Polymerase Chain Reaction Methods for Screening for Porcine Endogenous Retroviruses-C (PERV-C) in Pigs [PDF]

Viruses
Porcine endogenous retrovirus C (PERV-C) is a gammaretrovirus present in the genome of many, but not all, pigs. It is an ecotropic virus, able to infect only pig cells.
Hina Jhelum, Dusan Kunec, Vasileios Papatsiros, Benedikt B. Kaufer, Joachim Denner   +4 more
doaj   +9 more sources

Rare isolation of human-tropic recombinant porcine endogenous retroviruses PERV-A/C from Göttingen minipigs [PDF]

Virology Journal, 2022
Background Porcine endogenous retroviruses (PERVs) can infect human cells and pose a risk for xenotransplantation when pig cells, tissues or organs are transplanted to human recipients.
Sabrina Halecker, Ludwig Krabben, Yannick Kristiansen, Luise Krüger, Lars Möller, Dietmar Becher, Michael Laue, Benedikt Kaufer, Christian Reimer, Joachim Denner   +9 more
doaj   +10 more sources

Neutralizing Antibodies Against the Porcine Endogenous Retroviruses (PERVs) [PDF]

Viruses
Xenotransplantation using pig cells, tissues or organs may be associated with the transmission of porcine zoonotic or xenozoonotic microorganisms. Porcine endogenous retroviruses (PERVs) pose a special risk for xenotransplantation as these viruses can ...
Jinzhao Ban, Ludwig Krabben, Benedikt B. Kaufer, Joachim Denner   +3 more
doaj   +7 more sources

Determination of the Copy Number of Porcine Endogenous Retroviruses (PERV) in Auckland Island Pigs Repeatedly Used for Clinical Xenotransplantation and Elimination of PERV-C [PDF]

Microorganisms, 2023
Auckland Island pigs represent an inbred population of feral pigs isolated on the sub-Antarctic island for over 100 years. The animals have been maintained under pathogen-free conditions in New Zealand; they are well characterized virologically and have ...
Uwe Fiebig, Luise Krüger, Joachim Denner   +2 more
doaj   +7 more sources

Copy Number and Prevalence of Porcine Endogenous Retroviruses (PERVs) in German Wild Boars [PDF]

Viruses, 2020
Porcine endogenous retroviruses (PERVs) are integrated in the genome of pigs and are transmitted like cellular genes from parents to the offspring. Whereas PERV-A and PERV-B are present in all pigs, PERV-C was found to be in many, but not all pigs.
Luise Krüger, Milena Stillfried, Carolin Prinz, Vanessa Schröder, Lena Katharina Neubert, Joachim Denner   +5 more
doaj   +7 more sources

Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology [PDF]

Health Care Sci
Bringing attention to the moral dilemmas raised by xenotransplantation and the continuous creation of standardized frameworks for donor technology and biosafety risk management, with a focus on striking a balance between patient safety, medical innovation, and ethical obligation.
Saha S, Dutta M, Bosu A.
europepmc   +2 more sources

Global Consultation for Clinical Xenotransplantation: International Xenotransplantation Association Consensus and Communiqué Update. [PDF]

Xenotransplantation
ABSTRACT Xenotransplantation has entered a phase of accelerated clinical translation, necessitating renewed international consensus on governance, ethics, safety, and regulatory oversight. In September 2025, the International Xenotransplantation Association (IXA), in partnership with The Transplantation Society (TTS) and with engagement from the World ...
Hawthorne WJ, Wolf E, Cowan PJ, Wang W, Yun IJ, Brenner P, Korbutt G, Meier RPH, Sykes M, Bühler LH, Scobie L, Garkavenko O, Kim H, Hurst DJ, Iii RNP, Rieben R, Pascual M, Scholes-Robertson N, Cozzi E, Abalovich A, Loupy A, Hara H, Bottino R, Ekser B, Mohiuddin MM, Fishman J.   +25 more
europepmc   +2 more sources

Monitoring for PERV Following Xenotransplantation [PDF]

Transplant International
Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs. PERV-A, PERV-B and PERV-C can be released as infectious virus particles and PERV-A and PERV-B can infect human cells in culture.
Joachim Denner
doaj   +2 more sources

Porcine kidney xenotransplantation: From primate models to clinical reality. [PDF]

Animal Model Exp Med
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Guo Z, Zhang L, Deng S, Qin C.
europepmc   +2 more sources