Results 31 to 40 of about 516,407 (164)

Virological and Parasitological Characterization of Mini-LEWE Minipigs Using Improved Screening Methods and an Overview of Data on Various Minipig Breeds

Microorganisms, 2021
Minipigs play an important role in biomedical research and have also been used as donor animals in xenotransplantation. To serve as a donor in xenotransplantation, the animals must be free of potential zoonotic viruses, bacteria and parasites.
Sabrina Halecker, Julia Metzger, Christina Strube, Ludwig Krabben, Benedikt Kaufer, Joachim Denner   +5 more
doaj   +1 more source

Evidence for Microchimerism in Baboon Recipients of Pig Hearts

Viruses, 2023
Xenotransplantation, like allotransplantation, is usually associated with microchimerism, i.e., the presence of cells from the donor in the recipient.
Hina Jhelum, Martin Bender, Bruno Reichart, Maren Mokelke, Julia Radan, Elisabeth Neumann, Ludwig Krabben, Jan-Michael Abicht, Benedikt Kaufer, Matthias Längin, Joachim Denner   +10 more
doaj   +1 more source

Co-Cultivation Assays for Detecting Infectious Human-Tropic Porcine Endogenous Retroviruses (PERVs). [PDF]

Int J Mol Sci
Porcine endogenous retroviruses (PERVs) are integrated into the genome of all pigs. Since they can be released as infectious virus particles capable of infecting human cells in vitro, they pose a potential risk for xenotransplantation involving pig cells or organs.
Denner J.
europepmc   +3 more sources

Ancient origin and complex evolution of porcine endogenous retroviruses

Biosafety and Health, 2020
Porcine endogenous retroviruses (PERVs) are proviruses that have medical value in xenotransplantation. However, the evolutionary process leading to the generation of modern PERVs is not well understood.
Yicong Chen, Mingyue Chen, Xiaoyan Duan, Jie Cui   +3 more
doaj   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

The restriction of zoonotic PERV transmission by human APOBEC3G. [PDF]

PLoS ONE, 2007
The human APOBEC3G protein is an innate anti-viral factor that can dominantly inhibit the replication of some endogenous and exogenous retroviruses. The prospects of purposefully harnessing such an anti-viral defense are under investigation.
Stefán R Jónsson, Rebecca S LaRue, Mark D Stenglein, Scott C Fahrenkrug, Valgerdur Andrésdóttir, Reuben S Harris   +5 more
doaj   +1 more source

First virological and pathological study of Göttingen Minipigs with Dippity Pig Syndrome (DPS).

PLoS ONE, 2023
Dippity Pig Syndrome (DPS) is a well-known but rare complex of clinical signs affecting minipigs, which has not been thoroughly investigated yet. Clinically affected animals show acute appearance of red, exudating lesions across the spine.
Hina Jhelum, Nanna Grand, Kirsten Rosenmay Jacobsen, Sabrina Halecker, Michelle Salerno, Robert Prate, Luise Krüger, Yannick Kristiansen, Ludwig Krabben, Lars Möller, Michael Laue, Benedikt Kaufer, Kari Kaaber, Joachim Denner   +13 more
doaj   +1 more source

Unexpected low expression of porcine endogenous retroviruses (PERVs) in porcine expanded potential stem cells (EPSCs)

Virus Research, 2021
Expanded potential stem cells (EPSCs) have been recently derived from porcine preimplantation embryos (Gao et al., 2019). These cells were shown to express key pluripotency genes, to be genetically stable and differentiate to derivatives of the three germ layers and additionally to trophoblast.
Luise, Krüger, Monika, Nowak-Imialek, Yannick, Kristiansen, Doris, Herrmann, Björn, Petersen, Joachim, Denner   +5 more
openaire   +2 more sources

Natural Antibodies Prevent in Vivo Transmission of Porcine Islet-Derived Endogenous Retrovirus to Human Cells

Cell Transplantation, 2004
The discovery of porcine endogenous retroviruses (PERV) has raised concerns regarding the safety of porcine xenotransplantation. However, transmission of PERV had not been observed in humans exposed to porcine tissue.
Brice W. Mckane, Sabarinathan Ramachandran, Xiao-Chun Xu, Barbara J. Olack, William C. Chapman, T. Mohanakumar Ph.D.   +5 more
doaj   +1 more source

A paradigm for virus-host coevolution: sequential counter-adaptations between endogenous and exogenous retroviruses [PDF]

, 2007
Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections of the host germline transmitted 1vertically from generation to generation. It is hypothesized that some ERVs are used by the host as 1restriction factors to block the infection
Pereira, Filipe, LEYMASTER K, Pereira, P., Golder, Matthew, James C Demartini, Leymaster, Kreg, Mura, M., Mura, Manuela, Golder, M., Biek, R., Pereira Filipe, Golder, Matthew C., Arnaud, Frederick, Bernardo Chessa, Yu Li, CAPORALE M, Zhang, Y-P., Matthew Golder, Thomas E Spencer, Caporale Marco, Palmarini, Massimo, Alberti Alberto, Yu, Li, Arnaud Frederick, Biek Roman, Frederick Arnaud, Alberti, A., Arnaud, F., Spencer Thomas E, Ya-Ping Zhang, SPENCER T. E, Caporale, M., Li Yu, Palmarini, M., Varela, M., Kreg Leymaster, PEREIRA F, DeMartini, J.C., Zhang, Ya-ping, Mariana Varela, Spencer, T.E., ZHANG Y. P, Chessa, B., Chessa Bernardo, Mura Manuela, Alberto Alberti, Roman Biek, Varela Mariana, Leymaster Kreg, Spencer, Thomas,, ARNAUD F, BIEK R, Varela, Mariana, YU L, Golder Matthew, PALMARINI M., Chessa, Bernardo, Palmarini Massimo, Spencer, Thomas E., Manuela Mura, Biek, Roman, Spencer, Thomas E, DeMartini, James C., Leymaster, K., Filipe Pereira, Marco Caporale, Massimo Palmarini, Demartini, James, Demartini, James C, GOLDER M, DeMartini James C, Malim, Michael H, Yu, L., VARELA M, Caporale, Marco, Zhang Ya-ping, MURA M, DEMARTINI J. C, Alberti, Alberto   +78 more
core   +1 more source