Results 21 to 30 of about 1,247 (177)

How to Detect Porcine Endogenous Retrovirus (PERV) Infections in Patients After Transplantation of Pig Organs. [PDF]

Xenotransplantation
Porcine endogenous retroviruses (PERVs) are integrated into the genome of all pigs and can infect human cells in culture. However, no PERV infections have been reported in recipients following preclinical or clinical xenotransplantation or deliberate ...
Denner J, Jhelum H, Ban J, Krabben L, Kaufer BB.   +4 more
europepmc   +3 more sources

Increased titers of neutralizing antibodies after immunization with both envelope proteins of the porcine endogenous retroviruses (PERVs) [PDF]

Virology Journal, 2012
Despite enormous difficulties to induce antibodies neutralizing HIV-1, especially broadly neutralizing antibodies directed against the conserved membrane proximal external region (MPER) of the transmembrane envelope protein, such antibodies can be easily
Denner Joachim, Mihica Debora, Kaulitz Danny, Schmidt Christa-Maria   +3 more
doaj   +4 more sources

Screening for Viruses in Indigenous Greek Black Pigs [PDF]

Microorganisms
The successful advancement of xenotransplantation has led to the development of highly sensitive detection systems for the screening of potentially zoonotic viruses in donor pigs and preventing their transmission to the recipient.
Hina Jhelum, Vasileios Papatsiros, Georgios Papakonstantinou, Ludwig Krabben, Benedikt Kaufer, Joachim Denner   +5 more
doaj   +2 more sources

Distribution and expression of porcine endogenous retroviruses in multi-transgenic pigs generated for xenotransplantation [PDF]

Xenotransplantation, 2009
Background: Multi-transgenic pigs produced for use in xenotransplantation have to be screened for the presence and expression of porcine endogenous retroviruses (PERV) to select animals with low PERV load.
Denner, Joachim, Dieckhoff, Britta, Jobst, Danny, Kessler, Barbara, Kues, Wilfried A., Kurth, Reinhard, Niemann, Heiner, Petersen, Björn, Pfeifer, Alexander, Wolf, Eckhard   +9 more
core   +3 more sources

The role of human SAMHD1 in restricting porcine endogenous retroviruses (PERVs) and the innate immune response to PERV infection in human primary immune cells [PDF]

, 2021
Die Freisetzung von Porcinen Endogenen Retroviren (PERVs) aus Schweinezellen ist ein potenzieller Risikofaktor während der Xenotransplantation. PERV ist in der Lage, in humanen Zelllinien zu replizieren.
Al-shehabi, Hussein
core   +4 more sources

Genomic Validation of PERV-C-Free Pigs to Support Xenotransplantation. [PDF]

Xenotransplantation
ABSTRACT Porcine endogenous retroviruses (PERVs) are present in the germ lines of domesticated pigs (Sus scrofa) and related suids. There are three types of PERVs, PERV‐A, ‐B, and ‐C, which differ in their host range. PERV‐A and ‐B can infect human and porcine cells, while PERV‐C only infects porcine cells. PERV‐A and ‐B are found in the genomes of all
Benjamin NR, Madrigal G, Ishida Y, Catchen J, Allen KL, Pepin B, Roca AL.   +6 more
europepmc   +2 more sources

Removal of Porcine Endogenous Retroviruses in Decellularized Liver Bioscaffolds. [PDF]

Xenotransplantation
ABSTRACT Tissue engineering using decellularized liver scaffolds presents a promising approach in regenerative medicine, offering a potential alternative to donor organ transplantation. The use of human livers as a bioscaffold is restricted by their limited availability and quality.
van Hengel EVA, Drabek D, Roest HP, Willemse J, Reniers LJ, Stallmann H, de Jonge J, Grosveld FG, van der Laan LJW, Verstegen MMA.   +9 more
europepmc   +2 more sources

Liver Xenotransplantation: Ethical and Societal Implications. [PDF]

Xenotransplantation
ABSTRACT The shortage of transplantable livers and high waitlist mortality rates have accelerated the clinical translation of liver xenotransplantation. Recent milestones, including extracorporeal perfusion models and gene‐edited pig‐to‐human transplants in both decedents and living patients, indicate that clinical trials may be imminent.
Hurst DJ, Bobier CA, Padilla LA, Merlocco A, Meier RPH.   +4 more
europepmc   +2 more sources

Porcine Corneal Tissue and Xenozoonotic Risks: A Review of the Current Evidence. [PDF]

Xenotransplantation
ABSTRACT Corneal opacities affect millions worldwide, with corneal transplantation as the primary treatment. However, donor shortages remain a challenge, leaving thousands waiting for transplants. Xenotransplantation using porcine corneas has emerged as a promising alternative due to anatomical and physiological similarities with human corneas ...
Moreira R, Nascimento H, Martins TMDM, Barbieri G, Pires P, Carvalho LN, Rosa LR, Almeida A, Pessuti CL, Ferrer H, Gomes JÁP, Goulart E, Raia S, Belfort R.   +13 more
europepmc   +2 more sources

Transmission of Porcine Endogenous Retrovirus Produced from Different Recipient Cells In Vivo. [PDF]

PLoS ONE, 2016
Humanized pigs have been developed to reduce the incidence of immune rejection in xenotransplantation, but significant concerns remain, such as transmission of viral zoonosis. Porcine endogenous retroviruses (PERV), which exist in the genome of pigs, are
Nayoung Kim, Jiwon Choi, Sehyun Kim, Yong-Dae Gwon, Yeondong Cho, Jae Myung Yang, Yu-Kyoung Oh, Young Bong Kim   +7 more
doaj   +1 more source