Characterization of Insertional Variation of Porcine Endogenous Retroviruses in Six Different Pig Breeds [PDF]
Asian-Australasian Journal of Animal Sciences, 2012 Pigs may need to be exploited as xenotransplantation donors due to the shortage of human organs, tissues and cells. Porcine endogenous retroviruses (PERVs) are a significant obstacle to xenotransplantation because they can infect human cells in vitro and
W. Y. Jung +7 more
doaj +3 more sources
Virus safety of xenotransplantation and porcine endogenous retroviruses (PERVs) [PDF]
, 2014 Introduction: The shortage of organs for patients is an issue that needs addressing. Xenotransplantation using pig cells or organs is the most favored option. However, pigs contain porcine endogenous retroviruses (PERV) in their genome which infect human cells. Like all retroviruses PERVs have immunosuppressive properties and may induce tumors.
Anders, Maximilian
openaire +4 more sources
Advancing Type 1 Diabetes Treatment: 3 PM-Oriented Innovations in Islet Transplantation and Biomaterial Engineering. [PDF]
Diabetes Metab Res RevABSTRACT Type 1 Diabetes (T1D) is an autoimmune disorder marked by the immune‐mediated destruction of pancreatic β‐cells, resulting in insulin deficiency and dysregulated glucose control. Current therapies—such as insulin replacement and artificial pancreas systems—manage symptoms but fail to restore endogenous β‐cell function or halt disease ...
Sabet Sarvestani F +4 more
europepmc +2 more sources
Increased titers of neutralizing antibodies after immunization with both envelope proteins of the porcine endogenous retroviruses (PERVs) [PDF]
Virology Journal, 2012 Despite enormous difficulties to induce antibodies neutralizing HIV-1, especially broadly neutralizing antibodies directed against the conserved membrane proximal external region (MPER) of the transmembrane envelope protein, such antibodies can be easily
Denner Joachim +3 more
doaj +4 more sources
Xenoperfusion-The Transformative Role of Machine Perfusion in Xenotransplantation. [PDF]
XenotransplantationABSTRACT Recent advances in xenotransplantation have gained substantial public and clinical attention as genetically modified porcine organs are now being transplanted into living human recipients. While only case reports have been published to date, the first clinical trials for kidney xenotransplantation are now ongoing.
Huwyler F +3 more
europepmc +2 more sources
Removal of Porcine Endogenous Retroviruses in Decellularized Liver Bioscaffolds. [PDF]
XenotransplantationTissue engineering using decellularized liver scaffolds presents a promising approach in regenerative medicine, offering a potential alternative to donor organ transplantation.
van Hengel EVA +9 more
europepmc +2 more sources
[Endogenous porcine retroviruses and xenotransplantation]
, 2000 Vertebrate DNA contains numerous genomes closely related to retroviruses, i.e. endogenous retroviruses. While most of the retroviruses are pathogenous, endogenous retroviruses have rarely been shown as such.
Mornex, Jean-Francois
core +7 more sources
Transmission of Porcine Endogenous Retrovirus Produced from Different Recipient Cells In Vivo. [PDF]
PLoS ONE, 2016 Humanized pigs have been developed to reduce the incidence of immune rejection in xenotransplantation, but significant concerns remain, such as transmission of viral zoonosis. Porcine endogenous retroviruses (PERV), which exist in the genome of pigs, are
Nayoung Kim +7 more
doaj +1 more source
Structure of the Core Postfusion Porcine Endogenous Retrovirus Fusion Protein
mBio, 2022 Retroviral elements from endogenous retroviruses have functions in mammalian physiology. The best-known examples are the envelope proteins that function in placenta development and immune suppression.
Trevor T. Dean +2 more
doaj +1 more source
Genome-wide inactivation of porcine endogenous retroviruses (PERVs) [PDF]
Science, 2015 Virally cleansing the pig genome Transplants from pigs could be a solution to a shortage of human organs for transplantation. Unfortunately, porcine endogenous retroviruses (PERVs) are rife in pigs and can be transmitted to humans, risking disease. L. Yang et al.
Yang, Luhan +13 more
openaire +4 more sources