How Active Are Porcine Endogenous Retroviruses (PERVs)? [PDF]
Viruses, 2016 Porcine endogenous retroviruses (PERVs) represent a risk factor if porcine cells, tissues, or organs were to be transplanted into human recipients to alleviate the shortage of human transplants; a procedure called xenotransplantation.
Joachim Denner
doaj +8 more sources
Can Antiretroviral Drugs Be Used to Treat Porcine Endogenous Retrovirus (PERV) Infection after Xenotransplantation? [PDF]
Viruses, 2017 Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs; they are released as infectious particles, and under certain conditions they can infect human cells. Therefore, they represent a risk when pigs are used as sources of cells,
Joachim Denner
doaj +4 more sources
Porcine Endogenous Retroviruses and Xenotransplantation, 2021 [PDF]
Viruses, 2021 Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs, and some of them are able to infect human cells. Therefore, PERVs pose a risk for xenotransplantation, the transplantation of pig cells, tissues, or organ to humans in ...
Joachim Denner
doaj +4 more sources
Differential resistance to cell entry by porcine endogenous retrovirus subgroup A in rodent species [PDF]
Retrovirology, 2007 Background The risk of zoonotic infection by porcine endogenous retroviruses (PERV) has been highlighted in the context of pig-to-human xenotransplantation. The use of receptors for cell entry often determines the host range of retroviruses.
Takeuchi Yasuhiro +2 more
doaj +2 more sources
Xenotransplantation: Reduction of the risk of transmission of porcine endogenous retroviruses (PERV) [PDF]
, 2014 Xenotransplantation using porcine cells, tissues or organs may reduce the widening gap between demand and supply of human donor organs. However, this may be hampered by the presence of porcine endogenous retroviruses (PERVs), which belong to the γ-retroviruses family and are integrated in the porcine genome and were shown to infect human cells in vitro.
Semaan, Marwan
openaire +4 more sources
Porcine Endogenous Retroviruses in Xenotransplantation—Molecular Aspects
Viruses, 2014 In the context of the shortage of organs and other tissues for use in human transplantation, xenotransplantation procedures with material taken from pigs have come under increased consideration.
Magdalena C. Kimsa +6 more
doaj +2 more sources
Generation of neutralising antibodies against porcine endogenous retroviruses (PERVs) [PDF]
Virology, 2011 Antibodies neutralising porcine endogenous retroviruses (PERVs) were induced in different animal species by immunisation with the transmembrane envelope protein p15E. These antibodies recognised epitopes, designated E1, in the fusion peptide proximal region (FPPR) of p15E, and E2 in the membrane proximal external region (MPER).
Kaulitz, Danny +5 more
openaire +3 more sources
Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing. [PDF]
Adv Sci (Weinh)We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Ma L +22 more
europepmc +2 more sources
How to Detect Porcine Endogenous Retrovirus (PERV) Infections in Patients After Transplantation of Pig Organs [PDF]
XenotransplantationPorcine endogenous retroviruses (PERVs) are integrated into the genome of all pigs and can infect human cells in culture. However, no PERV infections have been reported in recipients following preclinical or clinical xenotransplantation or deliberate ...
Joachim Denner
exaly +4 more sources
Liver Xenotransplantation: Ethical and Societal Implications. [PDF]
XenotransplantationABSTRACT The shortage of transplantable livers and high waitlist mortality rates have accelerated the clinical translation of liver xenotransplantation. Recent milestones, including extracorporeal perfusion models and gene‐edited pig‐to‐human transplants in both decedents and living patients, indicate that clinical trials may be imminent.
Hurst DJ +4 more
europepmc +2 more sources